Residual aspects of 2,4,5-T and an ester in sheep and cattle with observations on concomitant toxicological effects

Influence of 2,4-D and 2,4,5-T on in vitro Digestion of Forage Samples

“…Clark et al (1964) found that following the oral administration of 2,4-D-14C, the majority of the activity had passed through the blood within a 24-hour period and by the end of 28 hours post treatment 90% of the 2,4-D-l 4C was recovered in the sheep urine. Similar results have been reported for 2,4,5-T (Clark and Palmer, 1971;St. John et al, 1964).…”

“…Many scientists have undertaken research to determine the magnitude of herbicide contamination in by-products from animals fed varying amounts of these herbicides (Clark et al, 1964;Clark and Palmer, 1971;Leng, 1972). In general, they have concluded that: (1) residues of phenoxy herbicides are not likely to exceed 300 ppm in or on forage immediately after treatment with these herbicides at recommended rates for control of weeds and brush in pastures and rangelands; (2) generally, such residues decline rapidly with a half-life of 1 to 2 weeks depending on geographic location; and (3) residues of phenoxy herbicides and their phenolic moities are not likely to occur in milk, meat, or fat.…”

Residues of chlorophenoxy acid herbicides and their phenolic metabolites in tissues of sheep and cattle

“…Clark et al (1964) reported less than 0.05 ppm of 2,4-D in edible tissues of sheep resulting from a single oral dose of 4 mg/kg body weight. Clark and Palmer (1971) found 2,4,5-T residues of 0.08 ppm in omental fat of each of two sheep given four oral doses of either 0.15 or 0.75 mg/kg of the propylene glycol butyl ether esters of 2,4,5-T. In the same study, residues as high as 368 ppm of 2,4,5-T were found in the kidneys of animals killed by four daily 250 mg/kg doses of a 2,4,5-T ester.…”

Pesticide Residues

“…Clark and Palmer (86) determined residues of 2,4,5-T and an ester in sheep and cattle. The herbicide residues were determined as the methyl ester by microcoulometry Barker and coworkers (25) studied the distribution iind metabolism of carboxyl-14C-2,3,5-triiodobenzoic acid End 2,3 (125I),5(125I)-triiodobenzoic acid in the rat.…”