Residues of Macrolide antibiotics in eggs following medication of laying hens

Roudaut, Brigitte; Moretain, J. P.

doi:10.1080/00071669008417297

Cited by 28 publications

(22 citation statements)

References 6 publications

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“…Tylan Soluble ® was completely cleared from blood and all tissues at 5 days (120 hours) after the last dose. These data were consistent with those reported by [17]. [29] concluded and recommended that microbiological ADI of 6 µg/kg.b.wt (360 µg per 60 kg person) was established for tylosin.…”

Section: Discussionsupporting

confidence: 83%

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Soliman¹,

Sedek²

2016

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The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with Vd(area) of 6 L/kg and eliminated with half-life (t1/2β) equal to 7.29 hours. The disposition kinetics of tylosin following oral administration revealed that the maximum blood concentration (Cmax) was 3.40 µg/ml attained at (tmax) of 1.08 hour. Tylosin was eliminated with half-life (t1/2β) equal to 5.78 hours. The mean systemic bioavailability of tylosin after oral administration was 90.29%. Following repeated oral administration of 50 mg tylosin base/kg.b.wt once daily for 5 consecutive days, the blood (µg/ml) and tissue (µg/g) residues of tylosin showed that liver, kidney and lung contained the highest tylosin residues and completely disappeared from those tissues at 6 days after the last oral dose. Chickens should not be slaughtered for human consumption within the treatment and 6 days after the last oral administrations of tylosin.

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Section: Discussionsupporting

confidence: 83%

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Soliman¹,

Sedek²

2016

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“…In addition, multifactorial causes including the oral bioavailability of the investigated drug and its physiochemical properties (molecular weight and solubility), the physiology of the chicken specimens as well as differences in the egg formation properties, organ perfusion characteristics, and tissue composition could also be likely reasons (Alaboudi, Basha, & Musallam, ; Bilandzic et al., ; Donoghue & Myers, ; Kan, ; Munoz et al., ). Roudaut and Moretain () stated that the differences in the sensitivities of the analytical methods used to detect drugs in egg matrices could also be a reason for the differences observed in their deposition patterns. Therefore, it is difficult to arrive at an overarching conclusion regarding the patterns of drug deposition and depletion in egg matrices, especially when one considers the differences in the metabolism, drug dose, and exposure time for laying hens.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers

Yang

Wang

et al. 2019

Journal of Food Science

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In the present study, we analyzed the tilmicosin residues in eggs as well as the dietary risks posed by the residual drug to Chinese consumers. Tilmicosin was administrated to laying hens via drinking water in doses of 100 mg/L and 300 mg/L (dose 1 and dose 2) for 5 days. Its residues distribution within egg matrices were detected using a QuEChERS method coupled with liquid chromatography–tandem mass spectrometry (LC‐MS/MS). The results indicated that the tilmicosin residue was the highest in the whole eggs and yolks on day 2 after medication and in the whites on day 5 of drug administration for dose 1 and dose 2 with the residues (µg/kg) being the following: 73.4 and 444.3 in the whole eggs; 152.0 and 1141.1 in the yolks; and 48.8 and 277.6 in the whites, respectively. During withdrawal phase, the tilmicosin levels declined to less than the limit of detection (LOD) after 29 days and 49 days for the whole eggs, after 24 days and 44 days for the yolks, and after 19 days and 49 days for the whites for doses 1 and 2, respectively. An assessment of the dietary risk for Chinese consumers revealed that the hazard quotients (HQ) values for tilmicosin consumption were less than 1 for dose 1 and greater than 1 for dose 2, with children (2 to 7 years) and adult males (over 65 years) being the high‐risk groups. These results suggest that the possible risk associated with tilmicosin contamination in eggs should not be ignored since the accidental or occasional misuse of tilmicosin in the case of egg‐laying hens may occur from time to time, particularly on small farms. Practical Application The modified QuEChERS method was used to analyze the tilmicosin residues in egg matrices and a subsequent dietary exposure assessment for Chinese consumers was performed, which can serve as a reference for the food safety risk posed by antibiotic misuse in egg layers.

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“…SDM and SDT were chosen because they are the most currently used sulphonamides in poultry farming in France and because they have diOE erent chemical characteristics. The work was part of a series of experiments undertaken by the French laboratory for veterinary drugs on the depletion of antibiotics into eggs (Roudaut et al 1987a, b, 1989, Roudaut 1990, 1998.…”

Section: Introductionmentioning

confidence: 99%

Sulphonamide residues in eggs following drug administration via the drinking water

Roudaut¹,

Garnier²

2002

Food Additives and Contaminants

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The aim was to determine concentrations of sulphadimidine (SDM) and sulphadimethoxine (SDT) in eggs following oral administration through drinking water for 5 days (0.5 g l(-1) for SDT, 1 and 2 g l(-1) for SDM). Residues of sulphonamides in albumen and yolk were monitored by high-performance liquid chromatography with UV detection. The limit of quantification was 0.005 microg g(-1) for the two egg components. The results indicate that 0.9-1.4% of the dose administered was deposited in eggs. Maximum concentrations in albumen were much higher than those in yolk. More than 75% of the overall sulphonamides detected in eggs was concentrated in the albumen. The residue levels declined below the limit of quantification within 12-20 days for albumen and 14-15 days for yolk after treatment was discontinued.

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Residues of Macrolide antibiotics in eggs following medication of laying hens

Cited by 28 publications

References 6 publications

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers

Sulphonamide residues in eggs following drug administration via the drinking water

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