Resistance exercise and naproxen sodium: effects on a stable PGF2α metabolite and morphological adaptations of the upper body appendicular skeleton

Brewer, Christi; Bentley, John P.; Day, Lainy B.; Waddell, Dwight E.

doi:10.1007/s10787-015-0248-x

Cited by 13 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PGD2 metabolites are also linked to DMD suggesting a role in muscle cell pathology 45 . Our findings support data obtained from human skeletal muscle 36 rather than from mice and rats 40,42 . Inflammation surprising.…”

Section: Discussionsupporting

confidence: 91%

“…PTGS is interesting because nonsteroidal anti-inflammatory drugs such as ibuprofen inhibit PTGS and are relevant for pain management 35 . PTGS-inhibitors influence on human skeletal muscle is controversially reported 34,[36][37][38] . In older patients performing resistance exercise under PTGSinhibition treatment, Type I fiber size increased up to 28% compared to control group 38 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A prostaglandin alpha F2 analog protects from statin-induced myopathic changes in primary human muscle cells

Popp

Haafke

et al. 2018

Preprint

View full text Add to dashboard Cite

Statins reduce plasma cholesterol levels and are effective in secondary cardiovascular disease prevention. However, statin related muscle side effects are a constant problem for patients and doctors because compliance in taking them is severely influenced by the side effects. The mechanism of statin-myopathy remains unknown.We exposed primary human muscle cell lines (n=4) to a lipophilic (simvastatin) and a hydrophilic More than 1800 transcripts and 900 proteins were differentially expressed after exposure to statins.Simvastatin had a much worse effect on the expressome than rosuvastatin, but both statins had a severe impact on cholesterol biosynthesis, fatty acid metabolism, eicosanoid synthesis, proliferation, and differentiation of human muscle cells. Eicosanoids rescued the biological function. We also found that muscle cells were very similarly equipped for cholesterol biosynthesis than HepG2 cell.Our data bring a new aspect to the role of skeletal muscle in cholesterol metabolism. For clinical practice, the addition of omega-3,6 fatty acids could be suitable to prevent or treat statin-myopathy.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

A prostaglandin alpha F2 analog protects from statin-induced myopathic changes in primary human muscle cells

Popp

Haafke

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…This result is somewhat in contrast to the findings of Brewer et al (25), who reported that a 440-mg dose of naproxen reduced the response of the metabolite prostaglandin F2α (PGF2α). Prostaglandin F2α (PGF2α) is directly related to the postexercise inflammatory process, and, consequently, its decreased activation would seemingly lead to lower sensation of DOMS (25,26). However, given that muscle damage was not measured directly, this finding should be taken with circumspection (25).…”

Section: Discussioncontrasting

confidence: 90%

“…For naproxen, Bourgeois et al showed that a 500-mg dose taken pre-and postexercise did not decrease perceived DOMS (24). This result is somewhat in contrast to the findings of Brewer et al (25), who reported that a 440-mg dose of naproxen reduced the response of the metabolite prostaglandin F2α (PGF2α). Prostaglandin F2α (PGF2α) is directly related to the postexercise inflammatory process, and, consequently, its decreased activation would seemingly lead to lower sensation of DOMS (25,26).…”

Section: Discussionmentioning

confidence: 91%

Naproxen’s Effect on Performance Within Neuromuscular Parameters

et al. 2019

View full text Add to dashboard Cite

This study investigated whether naproxen has an ergogenic effect on neuromuscular performance. A randomized, double-blind, placebo-controlled, crossover trial was conducted on 11 resistance-trained men who performed one strength-training session after taking 500 mg of naproxen and another session after taking a placebo. Participants performed three sets of the horizontal bench press with a load of 90% of repetition maximum (RM) to concentric failure. Outcome variables included number of repetitions, workload, fatigue index (FI), and delayed onset muscle soreness (DOMS). Results showed a statistically insignificant reduction in the number of repetitions for placebo when compared to naproxen, amounting to a relative difference of 44.89%. DOMS was lower in the naproxen group, but differences between conditions were not statistically significant. A statistically significant treatment effect was found for workload, favoring naproxen treatment. A statistically significant difference was found for FI between the second and third sets compared to the first set, with results favoring naproxen. We concluded that naproxen helps enhance neuromuscular outcomes in an acute high-intensity strength training bout.

show abstract

“…The inflammatory response is required for successful skeletal muscle regeneration . More specifically, neutrophils, macrophages, tumor necrosis factor alpha (TNF‐α), and cytokines (ie, interleukin 6 (IL‐6)) released by muscle fibers during muscle recovery mediate essential functions that regenerate skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

l‐arginine modulates inflammation and muscle regulatory genes after a single session of resistance exercise in rats

Morais

Brito

Mello

et al. 2017

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

We investigated the skeletal muscle adaptation to l-arginine supplementation prior to a single session of resistance exercise (RE) during the early phase of muscle repair. Wistar rats were randomly assigned into non-exercised (Control), RE plus vehicle (RE); RE plus l-arginine (RE+L-arg) and RE plus aminoguanidine (RE+AG) groups. Animals received four doses of either vehicle (0.9% NaCl), l-arg (1 g/b.w.), or AG (iNOS inhibitor) (50 mg/b.w.). The animals performed a single RE session until the concentric failure (ladder climbing; 80% overload) and the skeletal muscles were harvested at 0, 8, 24, and 48 hours post-RE. The RE resulted in increased neutrophil infiltrate (24 hours post-RE) (3621 vs 11852; P<.0001) associated with enhanced TNF-α (819.49 vs 357.02; P<.005) and IL-6 (3.84 vs 1.08; P<.0001). Prior, l-arginine supplementation attenuates neutrophil infiltration (5622; P<.0001), and also TNF-α (506.01; P<.05) and IL-6 (2.51, P<.05) levels. AG pretreatment mediated an inhibition of iNOS levels similar to levels found in RE group. RE animals displayed increased of atrogin-1 (1.9 fold) and MuRF-1 (3.2 fold) mRNA levels, reversed by l-arg supplementation [atrogin-1 (0.6 fold; P<.001); MuRF-1 (0.8-fold; P<.001)] at 24 hours post-RE. MyoD up-regulated levels were restricted to l-arg treated animals at 24 hours (2.8 vs 1.5 fold; P<.005) and 48 hours post-RE (2.4 vs 1.1 fold; P<.001). AG pretreatment reversed these processes at 24 hours [atrogin-1 (2.1 fold; P<.0001); MuRF-1 (2.5 fold; P<.0001); MyoD (1.4 fold)]. l-arginine supplementation seems to attenuate the resolution of RE-induced muscle inflammation and up-regulates MyoD expression during the early phase of muscle repair.

show abstract

Resistance exercise and naproxen sodium: effects on a stable PGF2α metabolite and morphological adaptations of the upper body appendicular skeleton

Abstract: Despite acute inhibition of the PGF2α metabolite at early time points, naproxen sodium did not hinder positive morphological adaptations of the upper body in response to resistance training.

Cited by 13 publications

References 32 publications

A prostaglandin alpha F2 analog protects from statin-induced myopathic changes in primary human muscle cells

A prostaglandin alpha F2 analog protects from statin-induced myopathic changes in primary human muscle cells

Naproxen’s Effect on Performance Within Neuromuscular Parameters

l‐arginine modulates inflammation and muscle regulatory genes after a single session of resistance exercise in rats

Contact Info

Product

Resources

About