Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression

López, Pedro; Taaffe, Dennis R.; Newton, Robert U.; Galvão, Daniel A.

doi:10.1249/mss.0000000000002503

Cited by 54 publications

(66 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of exercise oncology, the application of exercise medicine in cancer, has been well recognized in clinical oncology ( 5 ). Epidemiological ( 6 , 7 , 10 ) and clinical ( 8 , 9 ) studies examining the effect of exercise in PCa patients have further established the role of exercise in patient care for men with PCa. Moreover, exercise-induced circulating factor alteration, epigenetic modulation, and gene expression have been suggested as potential mechanisms whereby exercise may impact disease progression in men with PCa ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, increased lean mass in PCa patients might also positively impact patient outcomes ( 10 ). In our recent systemic review and meta-analysis of the efficacy of exercise in improving supportive care outcomes in PCa patients with a range of treatments, improvements (P<0.001) in whole-body fat mass (-0.6 kg), lean mass (+0.5 kg), and appendicular lean mass (+0.4 kg) after exercise compared to usual care were noted ( 9 ). Furthermore, in our randomized controlled trial involving 57 PCa patients undergoing androgen deprivation therapy (ADT), 3 months of exercise significantly increased muscle strength, physical function, lean mass, and a number of patient-reported outcomes ( 8 ).…”

Section: Exercise and Prostate Cancermentioning

confidence: 99%

“…Exercise or physical activity has been receiving attention in patient care in the oncology setting (5) due to the increasing body of research in the field of exercise oncology. Multiple epidemiological studies (6,7) and clinical trials (8)(9)(10) consistently report improvements in health-related outcomes for PCa patients. In addition, preclinical murine model studies have also demonstrated a reduced PCa tumor volume and delayed tumor growth with an exercise stimulus (11,12), and provide a strong mechanistic case for clinical trials to be tested on cancer outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression

et al. 2021

Self Cite

View full text Add to dashboard Cite

Physical exercise is increasingly recognized as a valuable treatment strategy in managing prostate cancer, not only enhancing supportive care but potentially influencing disease outcomes. However, there are limited studies investigating mechanisms of the tumor-suppressive effect of exercise. Recently, extracellular vesicles (EVs) have been recognized as a therapeutic target for cancer as tumor-derived EVs have the potential to promote metastatic capacity by transferring oncogenic proteins, integrins, and microRNAs to other cells and EVs are also involved in developing drug resistance. Skeletal muscle has been identified as an endocrine organ, releasing EVs into the circulation, and levels of EV-containing factors have been shown to increase in response to exercise. Moreover, preclinical studies have demonstrated the tumor-suppressive effect of protein and microRNA contents in skeletal muscle-derived EVs in various cancers, including prostate cancer. Here we review current knowledge of the tumor-derived EVs in prostate cancer progression and metastasis, the role of exercise in skeletal muscle-derived EVs circulating levels and the alteration of their contents, and the potential tumor-suppressive effect of skeletal muscle-derived EV contents in prostate cancer. In addition, we review the proposed mechanism of exercise in the uptake of skeletal muscle-derived EVs in prostate cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Exercise and Prostate Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the poor exercise-related reporting and lack of supervision also preclude us from determining if the minimal exercise stimulus to elicit benefits in QoL was achieved in this group of patients. 43 In this way, despite several studies demonstrating the benefits of exercise medicine on QoL in different cancer populations, 37 , 42 , 44 , 45 including metastatic disease, 46 methodologically sound trials with exercise interventions of appropriate mode and dosage are needed to determine exercise efficacy on QoL in patients with melanoma.…”

Section: Discussionmentioning

confidence: 99%

“… 33 , 34 This may be considered an important outcome for patients with melanoma given the benefits of resistance training programs on fatigue, muscle mass and metabolic health already demonstrated in other cancer populations. 37 , 43 …”

Section: Discussionmentioning

confidence: 99%

Associations of Physical Activity and Exercise with Health-related Outcomes in Patients with Melanoma During and After Treatment: A Systematic Review

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose: Although exercise medicine is recommended to counter treatment-related side-effects and improve health-related outcomes of patients affected by different cancers, no specific recommendations exist for patients with melanoma. As a result, we systematically examined the current evidence regarding the effects of physical activity and exercise on objectively-measured and patient-reported outcomes among patients with melanoma. Methods: Searches were conducted in PubMed, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases. This review included published data involving physical activity or exercise and objectively-measured or patient-reported outcomes of patients with cutaneous melanoma. The quality of included studies was assessed using the McMaster University Critical Appraisal Tool for Quantitative Studies. Results: Six studies including 882 patients with melanoma were included. Studies presented heterogeneity of design with 2 cross-sectional surveys, 2 retrospective analyses, and 2 non-randomized intervention trials. No statistically significant change in quality of life, fatigue, physical function, cardiorespiratory fitness, body composition, psychological distress, cognitive function, or treatment-related side-effects were attributable to physical activity or exercise. Importantly, physical activity or exercise during melanoma treatment or into survivorship did not adversely impact patients/survivors. Conclusion: In summary, physical activity or exercise did not adversely impact quality of life, objectively-measured or patient-reported outcomes in patients with melanoma. In addition, there is a paucity of quality studies examining the effects of physical activity or exercise on patients with melanoma throughout the cancer care continuum.

show abstract

Self‐reported lack of energy or feeling depressed 12 months after treatment in men diagnosed with prostate cancer within a population‐based registry

et al. 2021

View full text Add to dashboard Cite

Objective: Feeling depressed and lethargic are common side effects of prostate cancer (PCa) and its treatments. We examined the incidence and severity of feeling depressed and lack of energy in patients in a population based PCa registry. Methods:We included men diagnosed with PCa between 2015 and 2019 in Victoria, Australia, and enrolled in the Prostate Cancer Outcomes Registry. The primary outcome measures were responses to two questions on the Expanded Prostate Cancer Index Composite (EPIC-26) patient reported instrument: problems with feeling depressed and problems with lack of energy 12 months following treatment. We evaluated associations between these and age, cancer risk category, treatment type, and urinary, bowel, and sexual function.

show abstract

Resistance Exercise Dosage in Men with Prostate Cancer: Systematic Review, Meta-analysis, and Meta-regression

Abstract: Supplemental digital content is available in the text.

Cited by 54 publications

References 66 publications

Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression

Potential Role of Exercise Induced Extracellular Vesicles in Prostate Cancer Suppression

Associations of Physical Activity and Exercise with Health-related Outcomes in Patients with Melanoma During and After Treatment: A Systematic Review

Self‐reported lack of energy or feeling depressed 12 months after treatment in men diagnosed with prostate cancer within a population‐based registry

Contact Info

Product

Resources

About