Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans

Kim, Hee-jae; So, Byunghun; Choi, Mi‐Jung; Kang, Dongheon; Song, Wook

doi:10.1016/j.exger.2015.07.006

Cited by 131 publications

(128 citation statements)

References 24 publications

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“…This Hosseinzadeh, M., Rashid Lamir, A., Hejazi, S. M. (2018). Ann Appl Sport Sci, 6(1): 21-28. hormone is the protolithic product of FNDC5, whose expression is stimulated by physical activities and positive regulation of PPAR-γ and PGC1-α (35 The present study showed that eight weeks' resistance and endurance training can almost equally increase FNDC5 gene expression and irisin levels, which is in accordance with previous researches (21,32,35,37,38). For instance, Reisi et al (2015) observed increase in male rats' fat tissue FNDC5 gene expression after 8 weeks' endurance training (32).…”

Section: Discussionsupporting

confidence: 91%

Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?

Hosseinzadeh

Lamir

Hejazi

2018

Ann. Appl. Sport Sci

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Background. Irisin is the result of the proteolysis of fibronectin type III domain-containing protein 5, the levels of which are determined by physical activity. Objective(s). This study aims to identify changes in FNDC5 gene expression and the heart muscle irisin levels in male rats following 8 weeks resistance and endurance trainings. Methods. Fifteen male rats (10-12 weeks old and 331.8±63.09 g in weight) were randomly assigned to three groups: control, resistance and endurance training groups (5 in each group). The endurance group performed activities on a treadmill for 8 weeks. The resistance group performed activities for 8 weeks on a one-meter-long ladder with a slope of 85○. The control group did not undergo any particular training. Sampling was carried out 72 h after the end of the training. The heart tissue were excised, cleaned and immediately frozen in liquid nitrogen, and stored at -70○C. FNDC5 gene expression and the heart muscle irisin levels were measured using Real-Time PCR and ELISA, respectively. Results. Kruskal-Wallis test showed a significant increase in the heart muscle FNDC5 expression in both training groups (P=0.004). One-way ANOVA showed a significant difference in heart muscle irisin levels among the groups (p=0.004). Conclusion. It can be concluded that both resistance and endurance training can significantly increase FNDC5 gene expression and the heart muscle irisin levels, suggesting that physical activity can prevent and cure cardiovascular diseases.

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Section: Discussionsupporting

confidence: 91%

Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?

Hosseinzadeh

Lamir

Hejazi

2018

Ann. Appl. Sport Sci

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“…Kim, Lee, et al demonstrated an increase in circulating plasma irisin in overweight/ obese adults after 8 weeks of RT [19]. In a study with aging mice, Kim, et al So demonstrated that circulating irisin was significantly increased after 12 weeks of RT [20]. The results of the present study evidence the benefits of RT for metabolic responses when estrogen levels are reduced.…”

Section: Resistance Trainingsupporting

confidence: 73%

“…Irisin is a recently discovered hormone and there is little evidence on factors that may modulate its signaling. Is well established in the literature that RT promotes irisin release, and also increases cellular thermogenesis and reduces fat storage by suppressing formation of new adipocytes [19,20,[39][40][41]. Therefore, maintaining optimal irisin concentrations seems to be important, especially in our ovariectomy model, which has strong evidences of being a precursor of obesity and other metabolic disorders [42][43][44][45].…”

Section: Ovariectomymentioning

confidence: 90%

“…Quantification and measurement of irisin was performed using Irsin enzyme-linked immunosorbent assay (ELISA) Kit (EK-067-16, Phoenix Pharmaceuticals, CA, USA) and microreader [20]. 17β-Estradiol dosage was made with the commercial kit according to manufacturer's specifications (ADI-900-174, Enzo Life Sciences, Farmingdale, New York, USA).…”

Section: Elisa Assaymentioning

confidence: 99%

“…These benefits occur in part because skeletal muscle is an endocrine organ and exercise stimulates skeletal muscle to produce and release myokines, which have endocrine functions [15]. Irisin is a remarkable myokine and its concentration seems to increase in response to both endurance training and RT [16][17][18][19][20]. During physical exercise, the release of this moykine is induced by the activation of PPARγ co-activator 1 alpha (PGC1-α), which stimulates the fibronectin type III domain containing 5 (FNDC5) to cleave and release irisin into the blood [16].…”

Section: Introductionmentioning

confidence: 99%

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Irisin Signaling Pathway is up Regulated by Resistance Training in Ovariectomized Rats

Ns¹,

Mr²,

Lm³

et al. 2017

OCTOA

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Exercise is known to increase the concentrations of irisin, a remarkable myokine that may play an important protective role against metabolic disorders.Propose: This study investigated the effects of irisin signaling pathway induced by Resistance Training (RT) in ovariectomized (Ovx) rats.Methods: Thirty-two Holztman rats were randomly distributed to four experimental groups: Sham-Sedentary (Sed); Ovx-Sed; Sham-RT and Ovx-RT. The RT protocol demanded from the animals a vertical climb. Each session consisted of 4 to 12 climbs with 2 min. of rest during 12 weeks. To quantify mRNA expression the ∆∆Ct method was applied, protein expression was verified by Western Blotting and the analysis of irisin was determined by ELISA. When group averages were different (p ≤ 0.05), a Tukey post-hoc test was applied. Results:The Ovx-RT group had higher expression of PGC1α FNDC5, irisin levels, and UCP1 compared to Ovx-Sed. Conclusion:RT was led to higher expression of the irisin signaling pathway in the Ovx group showing that the RT seems to be an excellent strategy to counteract the ovariectomy-induced metabolic disorders.

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Myokines: A central point in managing redox homeostasis and quality of life

Rathor,

Suryakumar

2024

BioFactors

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Redox homeostasis is a crucial phenomenon that is obligatory for maintaining the healthy status of cells. However, the loss of redox homeostasis may lead to numerous diseases that ultimately result in a compromised quality of life. Skeletal muscle is an endocrine organ that secretes hundreds of myokines. Myokines are peptides and cytokines produced and released by muscle fibers. Skeletal muscle secreted myokines act as a robust modulator for regulating cellular metabolism and redox homeostasis which play a prime role in managing and improving metabolic function in multiple organs. Further, the secretory myokines maintain redox homeostasis not only in muscles but also in other organs of the body via stabilizing oxidants and antioxidant levels. Myokines are also engaged in maintaining mitochondrial dynamics as mitochondria is a central point for the generation of reactive oxygen species (ROS). Ergo, myokines also act as a central player in communicating signals to other organs, including the pancreas, gut, liver, bone, adipose tissue, brain, and skin via their autocrine, paracrine, or endocrine effects. The present review provides a comprehensive overview of skeletal muscle‐secreted myokines in managing redox homeostasis and quality of life. Additionally, probable strategies will be discussed that provide a solution for a better quality of life.

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Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans

Cited by 131 publications

References 24 publications

Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?

Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?

Irisin Signaling Pathway is up Regulated by Resistance Training in Ovariectomized Rats

Myokines: A central point in managing redox homeostasis and quality of life

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