2017
DOI: 10.1016/j.canlet.2017.02.027
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Resistance to metronomic chemotherapy and ways to overcome it

Abstract: Therapeutic resistance is amongst the major determinants of cancer mortality. Contrary to initial expectations, antivascular therapies are equally prone to inherent or acquired resistance as other cancer treatment modalities. However, studies into resistance to vascular endothelial growth factor pathway inhibitors revealed distinct mechanisms of resistance compared to conventional cytotoxic therapy. While some of these novel mechanisms of resistance also appear to be functional regarding metronomic chemotherap… Show more

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Cited by 32 publications
(23 citation statements)
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“…Independent comparisons and discussions of neoadjuvant chemotherapy and adjuvant chemotherapy were not mentioned in our study. As we know, the resistance of chemotherapy does not change with or without surgery [49]. A large number of studies have confirmed that MDCI shows the same efficacy in neoadjuvant chemotherapy and adjuvant chemotherapy [24,50].…”
Section: Discussionmentioning
confidence: 93%
“…Independent comparisons and discussions of neoadjuvant chemotherapy and adjuvant chemotherapy were not mentioned in our study. As we know, the resistance of chemotherapy does not change with or without surgery [49]. A large number of studies have confirmed that MDCI shows the same efficacy in neoadjuvant chemotherapy and adjuvant chemotherapy [24,50].…”
Section: Discussionmentioning
confidence: 93%
“…Perroud et al [12] postulated baseline VEGF and VEGF/sVEGFR-2 to be potential predictive biomarkers of response, and CECs of follow-up, in metronomic chemotherapy. Because of the well-known anti-angiogenic effects of LDMC, combinations with other agents targeting VEGF were evaluated [16,17]. A phase II trial with metronomic CTX and capecitabine in combination with bevacizumab showed a CBR of 68% ≥ 24 weeks and a mild toxicity profile in heavily pretreated MBC patients [18].…”
Section: Discussionmentioning
confidence: 99%
“…Different strategies to solve this problem were studied in preclinical and clinical models using thrombospondin 1 peptide ABT-510, VEGF pathway inhibitors, AKT inhibitor V, autophagy inducer rapamycin, autophagy inhibitor hydroxychloroquine and the tumor stroma modulating agents rofecoxib and pioglitazone. These therapeutic combinations may represent promising approaches to amplify MCT efficacy [102].…”
Section: Challenges and Future Directionsmentioning
confidence: 99%