Resolution of lichen planus following removal of amalgam restorations in patients with proven allergy to mercury salts: a pilot study

Smart, E.R.; Macleod, R I; Lawrence, C.M.

doi:10.1038/sj.bdj.4808663

Cited by 49 publications

(30 citation statements)

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“…These reactions are presumably due to allergic or toxic reactions to compounds released or generated, the Koebner phenomenon, or possibly due to plaque accumulated on the surfaces of the restorations (Holmstrup, 1991). Some of these oral lesions may improve after substitution of the amalgam by other materials (Finne et al, 1982;Jolly et al, 1986;Lind et al, 1986;Bolewska et al, 1990;Jameson et al, 1990;Skoglund and Egelrud, 1991;Laine et al, 1992;Bircher et al, 1993;Ostman et al, 1994;Henriksson et al, 1995;Smart et al, 1995;Bratel et al, 1996;Ibbotson et al, 1996), though this is often not the case with gingival lesions (Henriksson et al, 1995).…”

Section: (2) Drug-related White Lesions (A) Burns (See Above) (B) Licmentioning

confidence: 99%

Adverse Drug Reactions in the Orofacial Region

Scully

Bagán

2004

Critical Reviews in Oral Biology & Medicine

215

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A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.

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Section: (2) Drug-related White Lesions (A) Burns (See Above) (B) Licmentioning

confidence: 99%

Adverse Drug Reactions in the Orofacial Region

Scully

Bagán

2004

Critical Reviews in Oral Biology & Medicine

215

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“…These reactions are presumably due to allergic or toxic reactions to compounds released or generated, the Koebner phenomenon, or possibly plaque accumulated on the surfaces of the restorations (Holmstrup, 1991) Metal restorations Some lesions resembling OLP may occur in direct relation to amalgam restorations (Lundstrom, 1984;Lind et al, 1986;Bolewska et al, 1990a,b), and some of these oral lesions may improve after substitution of the amalgam by other materials (Finneetal., 1982;Jolly etal., 1986;Lind et al, 1986;Bolewska et al 1990a,b;Jameson et al, 1990;Skoglund and Egelrud, 1991;Laine et al, 1992;Bircher et al, 1993;Skoglund, 1994, Henriksson etal., 1995, Smartet al, 1995, Bratel et al, 1996Ibbotson et al, 1996), though this is often not the case with gingival lesions (Henriksson et al, 1995) Significant reactions to mercuric salts on skin-testing may be seen in some patients with OLP (Finne et al, 1982, Eversole andRinger, 1984;Mobacken et al, 1984a;lames et al, 1987;Ostman et al, 1994), though others have not found this (Hietanen et al, 1987) Finne et al (1982 demonstrated mercury sensitivity by patch testing in 62% of 29 patients with OLP and only 3.2% of a control group, and oral lesions regressed in a few patients when their amalgams were removed (Finne et al, 1982). Reactions to mercuric chloride have been reported (Skoglund and Egelrud, 1991;Smart et al, 1995). These…”

Section: Associations Of Olp With Systemic Diseasementioning

confidence: 99%

“…Intensive oral hygiene procedures may produce subjective and objective improvement of the lesions (Erpenstein, 1985;Holmstrup et al, 1990) and can also eliminate Candida from most lesions (Holmstrup et al, 1990). Attention should then be paid to the possibility of dental restorations inducing the lesions, since they may sometimes improve after replacement of amalgam with other restorative materials (Bolewska et at., 1990a,b;Skoglund and Egelrud, 1991;Smart et al, 1995;Ibbotson etal., 1996).…”

Section: Treatments In Oral Lichen Planusmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

477

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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“…19 It is good for dental use because it is strong, long lasting, well fitting, easy to handle, and cheap. Conventional silver amalgam fillings consist of about 50% mercury and about 50% alloy powder containing silver, tin, copper, and zinc.…”

Section: Commentmentioning

confidence: 99%

Oral Lichen Planus and Allergy to Dental Amalgam Restorations

Laeijendecker

Dekker²,

Burger³

et al. 2004

Arch Dermatol

108

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To determine contact allergies in patients with oral lichen planus and to monitor the effect of partial or complete replacement of amalgam fillings following a positive patch test reaction to ammoniated mercury, metallic mercury, or amalgam. Design:In group A (20 patients), the oral lesions were confined to areas in close contact with amalgam fillings. In group B (20 patients), the lesions extended 1 cm beyond the area of contact with amalgam fillings. In group C (20 patients), the oral lesions had no topographic relationship with amalgam fillings. Partial or complete replacement of amalgam fillings was recommended if there was a positive patch test reaction to ammoniated mercury, metallic mercury, or amalgam. Control group D (20 patients) had signs of allergic contact dermatitis.Results: Amalgam fillings were replaced in 13 patients of group A, with significant improvement. Dental amalgam

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Resolution of lichen planus following removal of amalgam restorations in patients with proven allergy to mercury salts: a pilot study

Cited by 49 publications

References 0 publications

Adverse Drug Reactions in the Orofacial Region

Adverse Drug Reactions in the Orofacial Region

Update On Oral Lichen Planus: Etiopathogenesis and Management

Oral Lichen Planus and Allergy to Dental Amalgam Restorations

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