Resorbable porous phosphate invert glasses-first in vitro and in vivo results

Vogel, J.; Schulze, K.; Reif, David M.; Hartmann, Peter; Platzbecker, Uwe; Leuner, B.

doi:10.1016/b978-008042692-1/50014-5

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…It was stated that relatively low dissolution rates were required for effective osteoblast proliferation in vitro and that application of these glasses in vivo may require different solubility rates due to the interaction or influence of other factors such as; pH, protein adhesion, rate of fluid exchange/flow, ionic concentration of environment, and/or interaction with other biological entities. In vitro and in vivo studies on invert PBG and glass ceramics of composition 32.6 P 2 O 5 , 27.6 CaO, 12.2 MgO, 27.6 Na 2 O (mol%) were conducted and the histological examinations conducted revealed no inflammation, thus good cytocompatibility was reported [18].…”

Section: Discussionmentioning

confidence: 99%

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Cytocompatibility and Effect of Increasing MgO Content in a Range of Quaternary Invert Phosphate-based Glasses

et al. 2009

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Recently, phosphate-based glass (PBG) fibers have been used to reinforce the biodegradable polymers polycaprolactone and polylactic acid, in order to fabricate materials suitable for use as resorbable bone fracture fixation devices. However, the PBG fibers investigated tended to degrade too quickly for application. Therefore, more durable PBG formulations were sought with emphasis remaining firmly placed on their biocompatibility. In this study, four invert PBG formulations (in the system P2O5-CaO-MgO-Na2O) were produced with fixed phosphate and calcium content at 40 and 25 mol%, respectively. MgO was added at 10-30 mol% in place of Na2O and the maximum divalent cation to phosphate ratio obtained was 1.375. Thermal analyses showed a linear increase in T(g) with increasing MgO content. This was proposed to be due to an increase in the cross-link density of the glass network, which also improved the chemical durability of the glass. EDX analyses were also conducted to verify the final composition of the glass. XRD analyses confirmed the amorphous nature of the glasses investigated. Rapid quenching of the Mg30 glass revealed a degree of surface crystallization, which was shown to be a CaMgP2O7 phase. The degradation rates of the glasses investigated decreased with increasing MgO content. The decrease in rate seen was almost two orders of magnitude (a x 50 difference was seen between glass Mg0 and Mg30). The cytocompatibility studies of the formulations investigated showed good cellular response over time for up to 14 days. Statistical analysis revealed that the formulations investigated gave a response comparable to the tissue culture plastic control. It is suggested that invert PBG provide degradation profiles and the cytocompatibility response desired to make these glasses useful for bone repair applications.

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Section: Discussionmentioning

confidence: 99%

“…In vitro and in vivo studies conducted on an invert PBG (of composition 32.6 P 2 O 5 -27.6 CaO-27.6 MgO-12.2 Na 2 O) showed excellent biocompatibility results [18]. For the in vivo studies, the glass was made porous via a salt sintering process and bone growth within the pores was reported.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility and Effect of Increasing MgO Content in a Range of Quaternary Invert Phosphate-based Glasses

et al. 2009

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“…The Q 3 species usually consists of 3D network and are called as 'ultraphosphates'. The Q 2 species usually consists of infinitely long chains and / or Glasses that are dominated in Q 0 and Q 1 species have also been known as 'invert glasses' [31,32]. According to Martin [33] the phosphate structured group in phosphate glasses when alkali halide is added changes from Q 3 to Q 2 to Q 1 to Q 0 as the ratio of M 2 O (or MO)/P 2 O 5 = R passes from 0 to 1 to 2 to 3.…”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of calcium phosphate based bioactive quaternary P2O5–CaO–Na2O–K2O glasses

Marikani¹,

Maheswaran²,

Premanathan³

et al. 2008

Journal of Non-Crystalline Solids

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“…Three different porous bone substitute materials were used as substrates for coating experiments: a resorbable phosphate glass (P 2 O 5 -CaO-MgO-Na 2 O, porosity: 65 %, Otto-Schott-Institute of the University of Jena [16]), a synthetic hydroxyapatite (HA) ceramic (Synthacer J , Heraeus Kulzer, Wehrheim, Germany), and a ß-tricalcium phosphate ceramic (Syntricer J , Heraeus Kulzer). Both the calcium phosphate ceramics have an inter-connective porosity of 65 -80 % and a standard pore size of 600 lm.…”

Section: Educts and Analytical Methodsmentioning

confidence: 99%

Resorbable Antibiotic Coatings for Bone Substitutes and Implantable Devices

Vogt

Kühn

Gopp

et al. 2005

Mat.-wiss. u. Werkstofftech.

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Antibiotic delivery systems based on biodegradable coatings have found considerable interest for the prophylaxis and local therapy of biomaterial-related infections. In this study sparingly watersoluble gentamicin salts have been prepared and tested as biodegradable antibiotic-releasing coating systems. Using the coating systems, homogeneous, well adhering films can be produced on various implant materials, like ceramics, glasses or metals surfaces, with different surface morphologies. The in vitro release profiles of the antibiotic coating systems were characterized by an initial burst release followed by a sustained release of small antibiotic amounts up to several weeks. It was found that the in vitro release, especially in the initial phase, can be modulated by the ratio between highly water-soluble gentamicin salts and sparingly soluble ones in the coating. Coating systems of the same type as described for gentamicin are available from a wide range of antibiotics differing in structure and mechanism of antibacterial action. Based on these results, the developed antibiotic coatings offer new perspectives to prevent and treat biomaterial-related infections.

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Resorbable porous phosphate invert glasses-first in vitro and in vivo results

Cited by 7 publications

References 3 publications

Cytocompatibility and Effect of Increasing MgO Content in a Range of Quaternary Invert Phosphate-based Glasses

Cytocompatibility and Effect of Increasing MgO Content in a Range of Quaternary Invert Phosphate-based Glasses

Synthesis and characterization of calcium phosphate based bioactive quaternary P2O5–CaO–Na2O–K2O glasses

Resorbable Antibiotic Coatings for Bone Substitutes and Implantable Devices

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