“…To extend this point, the fourth implication of our study derives from the translation of experimental data to clinical conditions exemplified by lung conditions ranging from acute lung injury to chronic remodeling disease. As noted above, the presently identified paradigm for PVLD appears to hold in varying forms across a broad sample of RNA viruses (IAV, SeV, EV-D68, RSV, HRV, and SARS-CoV) as studied in our lab and others (5,10,(58)(59)(60). The present data thereby links acute viral pneumonia to chronic bronchiolization as suggested in descriptive reports of presumed viral infection (11) and documented SARS-CoV-2 infection (27,43).…”