Respiratory Viruses in Bronchiolitis and Their Link to Recurrent Wheezing and Asthma

Mansbach, Jonathan M.; Camargo, Carlos A.

doi:10.1016/j.cll.2009.07.011

Cited by 26 publications

(36 citation statements)

References 147 publications

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“…Many studies have proposed that vitamin D concentration decreases due to the decrease in sunlight during the winter months, resulting in a related decrease in immune functions and sensitivity to influenza infections (12,13).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D Deficiency on the Severity of Bronchiolitis in Infants

Erol¹,

Kaya²,

Gayret³

et al. 2017

jpr

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Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D Deficiency on the Severity of Bronchiolitis in Infants

Erol¹,

Kaya²,

Gayret³

et al. 2017

jpr

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“…Recent vitamin D studies suggest that low levels of 25(OH)D are associated with increased risk of lower respiratory tract infections, wheezing illnesses and asthma in young children. 8,9 In addition, some observational studies reported that increased vitamin D in maternal diet may reduce the risk of recurrent wheezing. 10,11 Upper respiratory tract infections account for more than 80% of wheezing episodes in children.…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Levels Among Recurrently Wheezy Infants

Durmaz¹,

Asilsoy²,

Güç³

2013

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T OOb bj je ec ct ti iv ve e: : Epidemiologic studies have shown that low serum 25-hydroxyvitamin D (25(OH)D) levels are associated with increased risk of lower respiratory tract infections in young children. Almost all viral respiratory tract infections occur between November and March, months that also are associated with vitamin D deficiency. Vitamin D recently has been shown to have an important role in the immune regulation especially in innate immunity as well as production of antimicrobial peptides. In this study, we evaluated the relationship between serum 25(OH)D levels and recurrent respiratory tract infections with wheezing in young children. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Serum 25(OH)D levels were analysed in 60 wheezy infants, aged 6-36 months, with three or more viral wheezing episodes and 40 healthy controls at the same age. The study was done between November 2009 and March 2010, months that viral infection-associated wheezing episodes were common. Vitamin D levels were categorized into deficient (≤20 ng/mL), insufficient (21-29 ng/mL) and sufficient (≥30 ng/mL), based on previous recommendations. R Re es su ul lt ts s: : The mean serum 25(OH)D concentration of wheezy infants (30.1±7.6 ng/mL) was lower than the healthy controls (33.9±9.8 ng/mL) (p=0.049). Vitamin D deficiency was found in 7/60 (12%) of wheezy infants and 2/40 (5%) of healthy controls.Vitamin D insufficiency frequency was 21/60 (35%) in wheezy infants and 13/40 (32%) in healthy controls. The differences between wheezy infants and controls were insignificant. Serum vitamin D level was significantly associated with age, duration of breastfeeding and maternal clothing in wheezy infants. C Co on nc cl lu us si io on n: : Vitamin D insufficiency is prevalent among young children in our region. According to the previous studies supporting the role of vitamin D in innate immunity and antiviral defence, we suggest that it might be particularly important in wheezy children. Future investiagtions will demonstrate the exact role of vitamin D on respiratory tract infections and wheezing illnesses in young children.

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“…Second, we can consider risk modulators such as using palivizumab and emerging novel immunomodulatory therapies on these patients to help prevent RSV infections. Third, we can route these patients into future randomized clinical trials to advance bronchiolitis and asthma prevention research [207]. Fourth, by distinguishing early asthma patients from transient early wheezers, clinicians can better manage early wheezers [208].…”

Section: Predicting Whether a Bronchiolitis Patient Will Later Be Diamentioning

confidence: 99%

“…The model achieved a low sensitivity of 65%, a specificity of 82%, a low positive post-test probability around 50%, and a low negative post-test probability around 11%. At present, no predictive model for asthma diagnosis can attain satisfactory accuracy [206,207].…”

Section: Predicting Whether a Bronchiolitis Patient Will Later Be Diamentioning

confidence: 99%

A systematic review of predictive modeling for bronchiolitis

Luo

Nkoy

Gesteland

et al. 2014

International Journal of Medical Informatics

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Purpose: Bronchiolitis is the most common cause of illness leading to hospitalization in young children. At present, many bronchiolitis management decisions are made subjectively, leading to significant practice variation among hospitals and physicians caring for children with bronchiolitis. To standardize care for bronchiolitis, researchers have proposed various models to predict the disease course to help determine a proper management plan. This paper reviews the existing state of the art of predictive modeling for bronchiolitis. Predictive modeling for respiratory syncytial virus (RSV) infection is covered whenever appropriate, as RSV accounts for about 70% of bronchiolitis cases.Methods: A systematic review was conducted through a PubMed search up to April 25, 2014. The literature on predictive modeling for bronchiolitis was retrieved using a comprehensive search query, which was developed through an iterative process.Search results were limited to human subjects, the English language, and children (birth-18 years). Results:The literature search returned 2,312 references in total. After manual review, 168 of these references were determined to be relevant and are discussed in this paper. We identify several limitations and open problems in predictive modeling for bronchiolitis, and provide some preliminary thoughts on how to address them, with the hope to stimulate future research in this domain. Conclusions:Many problems remain open in predictive modeling for bronchiolitis. Future studies will need to address them to achieve optimal predictive models.

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Respiratory Viruses in Bronchiolitis and Their Link to Recurrent Wheezing and Asthma

Cited by 26 publications

References 147 publications

The Effect of Vitamin D Deficiency on the Severity of Bronchiolitis in Infants

The Effect of Vitamin D Deficiency on the Severity of Bronchiolitis in Infants

Serum Vitamin D Levels Among Recurrently Wheezy Infants

A systematic review of predictive modeling for bronchiolitis

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