Response of bone to tumor invasion

Milch, Robert Austin; Changus, George W.

doi:10.1002/1097-0142(195603/04)9:2<340::aid-cncr2820090221>3.0.co;2-c

Cited by 117 publications

(17 citation statements)

References 33 publications

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“…In most cases, prostate carcinoma 11,24 and often breast carcinoma 25 patients develop osteosclerotic bone metastases. Although very little is known about the mechanisms underlying the osteosclerotic bone metastasis, there has been a long-standing notion that bone resorption is a prerequisite for the development of osteosclerotic bone metastases.…”

Section: Questions Remained Unclear In Clinical Studiesmentioning

confidence: 99%

Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma

Yoneda¹,

Michigami²,

Yi³

et al. 2000

Cancer

186

120

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Section: Questions Remained Unclear In Clinical Studiesmentioning

confidence: 99%

Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma

Yoneda¹,

Michigami²,

Yi³

et al. 2000

Cancer

186

120

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“…Thus, in the myeloma patient, bone resorption can be seen to occur at multiple sites, but no repair of damaged bone occurs. It has previously been shown that the majority of tumours in bone evoke an osteoblastic response and new bone is formed at the site of injury [1][2][3], although this is not the only mechanism of new bone formation in the presence of metastases [4]. Thus, myeloma invasion of bone is different to other bone tumours, as no appreciable bone repair occurs.…”

Section: In~oducfionmentioning

confidence: 99%

Myeloma affects both the growth and function of human osteoblast-like cells

et al. 1992

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Myeloma behaves differently to other osteolytic tumours which metastasize to bone, in that the latter usually provoke reactive bone formation in the host bone. A previous study showed that a myeloma cell line (GM1500) secreted an osteoblast-inhibiting factor(s). The present study was undertaken to determine whether other myeloma cells also secreted a factor(s) which inhibited both cell proliferation and DNA synthesis of osteoblast-like cells and whether the myeloma also affected the function of osteoblasts. The results showed that a second cell line (Karpas 707) as well as myeloma tissue taken from two patients had a similar effect. The myeloma cells did not affect total collagen or protein synthesis, and did not affect the overall degree of mineralization. A biphasic effect was seen on alkaline phosphatase activity. Thus, although the proliferation of the pre-osteoblast was affected, the synthetic functions of the osteoblasts were not.

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“…The present study also suggests that skeletal metastases are associated with both the reactive formation of new bone and bone destruction. Milch and Changus examined microscopic sections of bone metastases in 241 patients with different types of cancer (Milch & Changus, 1956). They found a predominantly sclerotic type of lesion in 30% of lung cancers, in 60% of breast cancers, and in 90% of prostatic cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Milch and Changus postulated that reactive new bone represented a response to stress on the weakened bone similar to callus formation in fracture healing (Milch & Changus, 1956). Since reactive bone formation occurred in response to bone destruction, they regarded this as an attempt to repair the bone injury caused by the cancer.…”

Section: Discussionmentioning

confidence: 99%

New bone formation and cancer implants; relationship to tumour proliferative activity

Nemoto

1991

Br J Cancer

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SummaryThe interaction between tumour and bone with respect to the proliferative activity of transplanted tumour cells was studied using five transplantable human urogenital tumours in nude mice. Cells from those tumours were injected subcutaneously over the calvaria of nude mice following disruption of the periosteum. The extent of tumour-bone interaction varied with the type of implanted tumour as shown on X-ray and by histologic examinations of the calvaria. The classic histologic pattern of bone remodelling including the destruction of bone with proliferation of osteoclasts and reactive new bone formation was seen with all five tumours. Tumour proliferative activity determined from the tumour doubling time and the S-phase fraction using bromodeoxyuridine labelling showed that the rate of reactive bone formation appeared to be inversely proportional to the rate of tumour cell proliferation.We previously described a model for studying the interactions of tumour and bone in mice and had suggested the possibility of the development of skeletal metastases concurrent with the formation and destruction of bone (Nemoto et al., 1987;Nemoto et al., 1988;Nemoto et al., 1990b). In this investigation we describe the reaction of bone to transplanted tumours considering tumour doubling time and the S-phase fraction of transplantable human urogenital tumours in nude mice. Materials and methods Tumour transplantationSpecimens of malignant primary tumours were obtained at surgery. Fragments of tumour were aseptically implanted subcutaneously in the right flank of nude mice (Balb/c-nu/nu). The mice were maintained under pathogen-limited conditions. Five different urogenital tumours including two renal cell carcinomas (RCC4, RCC5), one transitional cell carcinoma of the renal pelvis (RPC1), one transitional cell carcinoma of the bladder (TCCI) and one prostate carcinoma (TSU-PRI) have been serially transplanted at intervals of 2 to 6 months without failure. All tumours preserved the histologic characteristics of the original tumours in nude mice.Considering the five tumours studied, RCC4 was a renal cell carcinoma from a patient with multiple osteolytic bone metastases and lung metastases. RCC5 was an invasive renal cell carcinoma from a patient who died of multiple osteolytic bone metastases and liver metastases. RPC1 was a poorly differentiated transitional cell carcinoma of the renal pelvis from a patient without distant metastases. TSU-PRI was a poorly differentiated carcinoma of the prostate from a patient with multiple bone metastases. His X-rays revealed osteoblastic bone metastases. TCC1 was a poorly differentiated transitional cell carcinoma of the bladder from a patient who died of multiple pulmonary metastases. formalin, and were radiographed with a Softex CSM using Kodak fine film for softex. X-rays were examined under blind conditions. The area of bone resorption from X-ray detectable lesions was measured by computerised analysis using Graphtec software for plotters.Histomorphometric evaluation of bone reaction (Pa...

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Response of bone to tumor invasion

Cited by 117 publications

References 33 publications

Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma

Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma

Myeloma affects both the growth and function of human osteoblast-like cells

New bone formation and cancer implants; relationship to tumour proliferative activity

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