The effect of (NH₄)₂SO₄:Ca(NO3)2 ratios applied by fertigation on nutritional status, fruit set, yield, and marketable yield of pomegranate trees cv. Wonderful was evaluated. The trees were provided with five nutrient solutions with the same total nitrogen level (200 units/ha) but with different (NH₄)₂SO₄:Ca(NO3)2 ratios (100:0, 90:10, 80:20, 70:30, and 60:40). Increasing the (NH₄)₂SO₄ ratio from 60 to 100% significantly reduced the nitrogen (N), magnesium (Mg), calcium (Ca), and potassium (K) concentrations while significantly increasing P and Fe concentrations in pomegranate leaves. The highest (NH₄)₂SO₄ proportion (100%) induced a reduction in both chlorophyll content and dry matter values in pomegranate leaves. The maximum fruit set (33.65% and 31.40%) and the minimum fruit drop (6.74% and 6.25%) were recorded at the applied ratio of 60% of (NH₄)₂SO₄:40% of Ca(NO3)2. The applied proportion of 70% of (NH₄)₂SO₄:30% of Ca(NO3)2 provided the minimum fruit sunburn (9.54% and 9.74%) and fruit cracking (6.45% and 5.64%), maximum yield (33.62 and 33.00 kg/tree), and marketable yield (27.41 and 27.93 kg/tree) in the 2019 and 2020 seasons, respectively. Our results provide valuable information about the effects of partial replacement of nitrogen fertilizer from (NH₄)₂SO₄ with nitrogen fertilizer from Ca(NO3)2 on the growth characteristics of pomegranate trees cv. Wonderful.