Response of Plasma Free Fatty Acids and Intraperitoneal Glucose Tolerance Test to Exercise in Trained and Untrained Rats

Simko, V; Chorváthová, V

doi:10.1159/000137182

Cited by 3 publications

(2 citation statements)

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“…Excercise results in a release of fatty acids from the adipose tissue and their rise in plasma (Simko and Chorvathova, 1969;Felig and Wahren, 1975;Fr6berg, 1971). Animals showing a significant decrease of liver cholesterol induced by chronic intermittent exercise had an increase in the serum total polyunsaturated fatty acids (Simko and Babala, 1964).…”

Section: Discussionmentioning

confidence: 99%

Physical exercise and the prevention of atherosclerosis and cholesterol gall stones

Simko

1978

Postgraduate Medical Journal

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Summary There is accumulating evidence in man and experimental animals that even mild exercise, if regularly repeated, may alter the metabolism of lipids. Exercise has been reported as decreasing peripheral tissue cholesterol in red blood cells, working muscle, lungs and the liver. During physical activity, the output of cholesterol and bile acids into the bile increases. This probably leads to higher faecal losses of sterols which may lead to lower cholesterol levels in the peripheral tissues and in the bile, when exercise is repeated regularly. Preferential release of unsaturated fatty acids from the adipose tissue during exercise and the linoleic acid-dependent LCAT enzyme (transporting plasma cholesterol) may be partly responsible for this effect of exercise. The experimental data reviewed provide supportive basis for epidemiological studies reporting on the beneficial effect of regular exercise. Physical activity is an important factor in the phylogeny of all animal species, secondary only to food intake and reproduction. Exercise is readily available to all population groups. There is good evidence that the amount of exercise required for a protective effect is easily accessible for time-pressured and older individuals. Short bursts of activity repeated several times a day may be equally or more beneficial than prolonged exhaustive exercise. Modified exercise is also beneficial for patients with coronary heart disease and for elderly patients, provided this is done under strict medical supervision. To be effective, physical exercise should be regular and continuous throughout life.

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Section: Discussionmentioning

confidence: 99%

Physical exercise and the prevention of atherosclerosis and cholesterol gall stones

Simko

1978

Postgraduate Medical Journal

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“…Exercise has been shown to increase lipolysis, resulting in a greater release of free fatty acids from adipose stores (32). Simko and Chorvathova (33) have reported that trained rats may have a lower level of free fatty acids in their plasma at rest and a lower, less prolonged elevation during subsequent exercise. Increases in fatty acid efflux from plasma during exercise can be related to an increased uptake and utilization by working muscles (34,35).…”

Section: Cholesterol Tomentioning

confidence: 99%

Effects of Training and Detraining on the Distribution of Cholesterol, Triglyceride, and Nitrogen in Tissues of Albino Rats

Watt

Foss

Block

1972

Circulation Research

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The effects of standardized exercise training and detraining on the content of cholesterol, triglyceride, and nitrogen in blood, myocardium, skeletal muscle, and epididymal fat of rats were studied. Forty-eight 90-day-old male rats were randomly assigned to four groups (two control groups, one trained group, and one trained and detrained group). Trained rats were subjected to 8 weeks of moderate running in motor-driven wheels; detraining was effected by discontinuing the running program for 8 weeks. Rats were provided a standard diet and water ad libitum. Trained rats displayed lower body weights and resting bradycardia. Training lowered (P<0.01) serum cholesterol, serum triglyceride, and adipose triglyceride levels but had no effect on these lipids in heart or skeletal muscle. These lowered lipid levels persisted after 8 weeks of detraining even though body weight was regained rapidly. Total nitrogen content was higher ( P < 0 . 0 1 ) in myocardial and triceps muscles of both trained and trained-detrained rats. Heart cholesterol and triglyceride levels were unchanged by detraining, but skeletal muscle cholesterol content was lowered. The results indicate that the changes in lipid content associated with training and detraining are tissue specific: reduction occurred in some tissues (serum and adipose tissue), although the lipid content of others (skeletal and heart muscle) was independent of training status, body weight, or circulating lipid levels. KEY WORDSskeletal muscle exercise adipose tissue lipids heart• Numerous studies indicate that physical activity lowers serum lipid concentrations in man ( 1 -3 ) and experimental animals (4-13).In the limited number of studies relating changes in tissue lipid content with physical activity, variable results have been reported for liver and skeletal muscle.detraining on tissue lipid levels have been reported by only one investigator ( 2 ) . This experiment was undertaken to determine the effects of a standardized exercise training program followed by a period of detraining on the content of lipid fractions in the blood and various other tissues of albino rats. Total nitrogen was also determined for myocardial and skeletal muscle in an attempt to associate lipid changes with protein changes. All analytical data for tissues except blood were expressed on a dry-weight basis. MethodsSixty-two 90-day-old male rats of the Sprague-Dawley strain were preliminarily tested in motordriven exercise wheels (modification of Waham LC-34 activity cage) to determine their willingness and ability to run. These tests consisted of four exercise sessions, each lasting 5 minutes, at 0.53 mph. Forty-eight rats were randomly 908

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Effect of Long-term Physical Exercise on Bile Sterols, Fecal Fat and Fatty Acid Metabolism in Rats

Simko¹,

Ondreicka²,

Chorváthová³

et al. 1970

The Journal of Nutrition

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Response of Plasma Free Fatty Acids and Intraperitoneal Glucose Tolerance Test to Exercise in Trained and Untrained Rats

Cited by 3 publications

References 0 publications

Physical exercise and the prevention of atherosclerosis and cholesterol gall stones

Physical exercise and the prevention of atherosclerosis and cholesterol gall stones

Effects of Training and Detraining on the Distribution of Cholesterol, Triglyceride, and Nitrogen in Tissues of Albino Rats

Effect of Long-term Physical Exercise on Bile Sterols, Fecal Fat and Fatty Acid Metabolism in Rats

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