We studied the effect of supplementation with vitamins C, E and beta-carotene (PARABION, produced by Syndipharma) on antioxidative status in kidneys of male Wistar rats with diabetes induced by intravenous application of streptozotocin (45 mg.kg-1 of body weight). The animals received subtherapeutic doses of Insulin Interdep (6 U.kg-1 of body weight). A significant decrease of malondialdehyde (MDA), reduced (GSH) and oxidized (GSSG) glutathione and reduction of the activities of Se-glutathione peroxidase (Se-GSH-PX, EC. 1.11.1.9.) and glutathione S-transferase (GST, EC. 2.5.1.18.) were observed in kidneys of diabetic rats treated with these vitamins. On the contrary, the activity of CuZn-superoxide dismutase (CuZn-SOD, EC. 1.15.1.1) and the level of vitamin C (vit. C) increased significantly. No changes were observed for vitamin E (vit. E), beta-carotene and catalase (CAT, EC. 1.11.1.6). Supplementation with vitamins C, E and beta-carotene resulted in an improvement of antioxidative status of kidneys of rats with streptozotocin-induced diabetes.

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1. Sixty patients after partial gastrectomy were subjected to the d-xylose test and to jejunal biopsy. The feces of 34 patients of this group were examined for fat excretion. 2. In about one third of the patients a pathological d-xylose test, higher fecal fat and inflammatory changes in jejunal mucosa were observed. 3. Pathological d-xylose test values and higher fecal fat excretion were found in both normal andpathological jejunal mucosa.

Several points of contact exist between the metabolism of glucose and vitamin C, which are two substances with a similar molecular structure. A deficiency of vitamin C provokes disorders in glycoregulation reminiscent of diabetes mellitus, and vice versa, diabetes brings about disorders in ascorbic acid metabolism, which may lead to a local vitamin C deficiency in some tissues. This vicious circle can be cut by an increased supply of ascorbic acid. Long-term administration of ascorbic acid depresses cholesterol level in blood serum in the majority of hypercholesterolemic diabetics. Prevention of chronic overt vitamin C deficiency in diabetics may play a positive role in the prevention of diabetic microangiopathies and atherosclerosis.