Recent developments indicate that the application of pultruded FRP profiles has been continuously growing in the construction industry. Generating more complex structures composed of pultruded FRP profiles requires joining them. In particular, I-shape glass fiber pultruded profiles are commonly used and the possible joints to connect them should be specifically studied. The mechanical behavior of adhesively and bolted joints for pultruded Glass FRP (GFRP) profiles has been experimentally addressed and numerically modeled. A total of nine specimens with different configurations (bolted joints, adhesive joints, web joints, web and flange joints, and two different angles between profiles) were fabricated and tested, extending the available published information. The novelty of the research is in the direct comparison of joint technologies (bolted vs. adhesive), joint configuration (web vs. flange + web) and angles between profiles in a comprehensive way. Plates for flange joints were fabricated with carbon fiber FRP. Experimental results indicate that adding the bolted flange connection allowed for a slight increase of the load bearing capacity (up to 15%) but a significant increase in the stiffness (between 2 and 7 times). Hence, it is concluded that using carbon FRP bolted flange connection should be considered when increasing the joint stiffness is sought. Adhesively connections only reached 25% of the expected shear strength according to the adhesive producer if comparing the numerically calculated shear strength at the failure time with the shear strength capacity of the adhesive. Apart from assessing adhesive connections, the implemented 3D numerical model was aimed at providing a simplified effective tool to effectively design bolted joints. Although the accurate fitting between experimental and numerical results of the mechanical response, especially the stiffness of the joint, the local failure experimentally observed was not automatically represented by the model, because of the simplified definition of the materials oriented to make the model available for a wide range of practitioners.