Response surface modeling of betulinic acid pre-concentration from medicinal plant samples by miniaturized homogenous liquid–liquid extraction and its determination by high performance liquid chromatography

Khajeh, Mostafa; Ghaffari‐Moghaddam, Mansour; Khajeh, Behrouz

doi:10.1016/j.arabjc.2013.03.001

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…The Adeq Precision value is the signal to noise ratio, which is greater than 4, with a ratio of 10.520, in the quadratic model, which indicates an adequate signal. Therefore, this model can be used to navigate spatial design [24,[26][27]. The Model F value is 10.99, and Prob > F less than 0.0500 indicates that the model is significant.…”

Section: Statistical Design Modelmentioning

confidence: 97%

“…Furthermore, RSM is also used to model and analyze the effect of the quantitative variable to obtain optimized results. The relationship between these variables can be described in the form of an equation [22][23][24]. Furthermore, the response used is the polyurethane membrane's physical or visual characteristics, which assign points to the characteristic level.…”

Section: ■ Introductionmentioning

confidence: 99%

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Optimization of Polyurethane Membrane Physical Characteristics of Red Seaweed Biomass Using a Box-Behnken Design

et al. 2021

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The polyurethane membrane is used as a separator either by filtration or adsorption, and this process is significantly affected by its strength and physical condition. We synthesized polyurethane membranes using red seaweed with Gracilaria sp as a hydroxyl source. The Box-Behnken Design of the Response Surface Methodology (RSM) using Software Design Expert Version 10.0.3.0 with three factors (TRL, TDI, and Glycerin). The F-value of 0.42 suggests that the membrane is less fit, while the P-value of 75.10% indicates that the quadratic design model is suitable for data analysis of physical characteristics. The optimal physical characteristics were obtained at a composition of 0.233 g TRL, 2.675 g TDI, and 0.254 g glycerin with a physical point of 6.5 (strong and elastic). Optimal polyurethane membrane has good thermal and mechanical properties at temperatures of Tg 58 °C, Tm 322 °C, and Td 534 °C, as well as stress and nominal strain values of 69.3 MPa and 5.74%. Polyurethane membrane synthesized from red seaweed has good physical properties. The result of this research is the basis for the development of polyurethane membrane applications from red seaweed.

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Section: Statistical Design Modelmentioning

confidence: 97%

Section: ■ Introductionmentioning

confidence: 99%

Optimization of Polyurethane Membrane Physical Characteristics of Red Seaweed Biomass Using a Box-Behnken Design

et al. 2021

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“…The coefficient of variations (C.V) for R1 and R2 were calculated as 3.1 and 4.39%, respectively. These low values of C.V indicate the high reliability and reproducibility of the conducted experiments [18,19]. To the best of the authors' knowledge, there is no study in the literature concerning the antioxidant activity of the leaf extracts of Sorbus umbellata (Desf.)…”

Section: Extraction Process Modeling and Optimized Extraction Conditionsmentioning

confidence: 99%

Sorbus umbellata (Desf.) Fritsch var. umbellata Leaves: Optimization of Extraction Conditions and Investigation Antimicrobial, Cytotoxic, and β-Glucuronidase Inhibitory Potential

Kavak

Akdeniz

2019

Plant Foods Hum Nutr

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This study aimed to optimize the extraction conditions for Sorbus umbellata (Desf.) Fritsch var. umbellata leaves to maximize the phenolic content and their antioxidant activity and to investigate β-glucuronidase (GUS) enzyme inhibitory, antimicrobial and cytotoxic potentials of the extracts obtained under optimum conditions. The optimum extraction conditions were found to be 78.2 and 79.7% solvent, 73.1 and 71.5°C, and 89.9 and 88.8 min to maximize phenolic content and antioxidant activity, respectively. Low values of coefficient of variations indicate the high reliability and reproducibility of the conducted extraction experiments. Bioactivity results showed that extracts had cytotoxic effect on the MCF-7 and A549 cells where the highest cell proliferation inhibition was observed for the A549 cell line (71.8% at 150 μg/mL). Staphylococcus aureus showed highest zone of inhibition (19.3 mm) in all bacteria followed by Escherichia coli. Additionally, extracts displayed potential GUS inhibitory activity. In conclusion, Sorbus umbellata leaf extract can be obtained by optimized cost-saving extraction and has a potential bioactivity to be utilized as a food ingredient for high value-added products and/or nutraceuticals development where it can combat oxidative stress and GUS mediated reactive metabolite formation.

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“…Актуальным остается вопрос: как оценить качество продукции быстро и во внелабораторных условиях? Для установления качества растительного сырья используются методы хроматографии [4][5][6][7][8], спектрофотометрии [9][10][11][12] и другие физикохимические методы [13][14][15][16][17][18]. Наиболее селективными являются хроматографические методы.…”

Section: Introductionunclassified

The study of herbs extracts composition in the drying process

Кучменко

Abramyan

2022

Vestn. Voronež. gos. univ. inž. tehnol.

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Medicinal and flavoring herbs are widely used in herbal medicine. Various methods are used to study plants, evaluate the efficiency of extraction of biologically active target components. The process control is carried out by chromatographic, spectral methods. The search for new fast, affordable, simple methods of analysis is currently relevant. The dry droplet weighing method of the extract was proposed as an alternative to the known methods. The analysis of flavoring herb parsley extracts by four methods (spectrophotometry, refractometry, thin layer chromatography and direct dry drop weighing) was carried out. The objects of study were fresh protected ground parsley and the Indana brand dried parsley. Fresh parsley was dried and the change in the chemical composition of water-alcohol extracts was monitored for 16 days. Compounds in the extracts were identified by differential spectra. It was found out that the amount of substances extracted from the flavoring herb was greater than in the dry sample after 12 days of drying. The composition of the mobile phase for thin layer fast chromatography was selected. The best separation of chlorophylls from related substances occurs at a volume ratio of toluene and ethyl alcohol of 5:5 and 6:4. The sensitivity of the refractometry method does not allow determining the difference in the composition of fresh parsley extracts. Using the method of direct piezoquartz microweighing, it was proved that with an increase in the drying time of parsley, the number of compounds in a dry drop of the extract increases. The most sensitive method i.e. piezoquartz microweighing, the MCNano-WPQ-8 device can be used in non-laboratory conditions for express monitoring of plant materials drying in small manufactures. it is simpler, cheaper, more compact and more sensitive than other devices. The device and approach were tested on various types of phyto raw materials.

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Response surface modeling of betulinic acid pre-concentration from medicinal plant samples by miniaturized homogenous liquid–liquid extraction and its determination by high performance liquid chromatography

Cited by 8 publications

References 16 publications

Optimization of Polyurethane Membrane Physical Characteristics of Red Seaweed Biomass Using a Box-Behnken Design

Optimization of Polyurethane Membrane Physical Characteristics of Red Seaweed Biomass Using a Box-Behnken Design

Sorbus umbellata (Desf.) Fritsch var. umbellata Leaves: Optimization of Extraction Conditions and Investigation Antimicrobial, Cytotoxic, and β-Glucuronidase Inhibitory Potential

The study of herbs extracts composition in the drying process

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