Response to F. Bochud and T. Jung: Comment on the human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities, Hagen Scherb &amp; Kristina Voigt, Environ Sci Pollut Res (2011) 18:697–707 (DOI: 10.1007/s11356-012-0767-6)

Interrupted time series analysis (ITSA) is a method that can be applied to evaluate health outcomes in populations exposed to ionizing radiation following major radiological events. Using aggregated time series data, ITSA evaluates whether the time trend of a health indicator shows a change associated with the radiological event. That is, ITSA checks whether there is a statistically significant discrepancy between the projection of a pre-event trend and the data empirically observed after the event. Conducting ITSA requires one to consider specific methodological issues due to unique threats to internal validity that make ITSA prone to bias. We here discuss the strengths and limitations of ITSA with respect to bias and confounding, data quality, and statistical aspects. We provide recommendations to strengthen the robustness of ITSA studies and reduce their susceptibility to producing spurious results as a consequence of arbitrary modelling decisions.

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Increased sex ratio in Russia and Cuba after Chernobyl: a radiological hypothesis

Scherb

Kusmierz

Voigt

2013

Environ Health

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BackgroundThe ratio of male to female offspring at birth may be a simple and non-invasive way to monitor the reproductive health of a population. Except in societies where selective abortion skews the sex ratio, approximately 105 boys are born for every 100 girls. Generally, the human sex ratio at birth is remarkably constant in large populations. After the Chernobyl nuclear power plant accident in April 1986, a long lasting significant elevation in the sex ratio has been found in Russia, i.e. more boys or fewer girls compared to expectation were born. Recently, also for Cuba an escalated sex ratio from 1987 onward has been documented and discussed in the scientific literature.Presentation of the hypothesisBy the end of the eighties of the last century in Cuba as much as about 60% of the food imports were provided by the former Soviet Union. Due to its difficult economic situation, Cuba had neither the necessary insight nor the political strength to circumvent the detrimental genetic effects of imported radioactively contaminated foodstuffs after Chernobyl. We propose that the long term stable sex ratio increase in Cuba is essentially due to ionizing radiation.Testing of the hypothesisA synoptic trend analysis of Russian and Cuban annual sex ratios discloses upward jumps in 1987. The estimated jump height from 1986 to 1987 in Russia measures 0.51% with a 95% confidence interval (0.28, 0.75), p value < 0.0001. In Cuba the estimated jump height measures 2.99% (2.39, 3.60), p value < 0.0001. The hypothesis may be tested by reconstruction of imports from the world markets to Cuba and by radiological analyses of remains in Cuba for Cs-137 and Sr-90.Implications of the hypothesisIf the evidence for the hypothesis is strengthened, there is potential to learn about genetic radiation risks and to prevent similar effects in present and future exposure situations.

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Response to F. Bochud and T. Jung: Comment on the human sex odds at birth after the atmospheric atomic bomb tests, after Chernobyl, and in the vicinity of nuclear facilities, Hagen Scherb & Kristina Voigt, Environ Sci Pollut Res (2011) 18:697–707 (DOI: 10.1007/s11356-012-0767-6)

Cited by 3 publications

References 22 publications

Modeling human genetic radiation risks around nuclear facilities in Germany and five neighboring countries: A sex ratio study

Modeling human genetic radiation risks around nuclear facilities in Germany and five neighboring countries: A sex ratio study

Methodological considerations for interrupted time series analysis in radiation epidemiology: an overview

Increased sex ratio in Russia and Cuba after Chernobyl: a radiological hypothesis

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