Responses of oxidative stress, genotoxicity and immunotoxicity as biomarkers in<i>Theba pisana</i>snails dietary exposed to silver nanoparticles

Radwan, Mohamed; El‐Gendy, K.S.; Gad, Amira F.; Khamis, Awatef E.; Eshra, E. H.

doi:10.1080/02757540.2019.1631816

Cited by 23 publications

(8 citation statements)

References 75 publications

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“…Chronic exposure of the T. pisana to Ag NPs caused alterations in hemocytes, such as micronuclei, binucleated cell and kidney-like nuclei (Radwan et al 2019). Also, B. glabrata exposed to CdTe quantum dot showed altered hemocytes binucleates, micronuclei, and apoptosis (de Vasconcelos Lima et al 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Biomphalaria snails immunology can be attributed to hemocyte which are the critical line of cellular defense (Larson et al 2014), where, they contributed in many defense mechanism against several pathogen as it is responsible for the phagocytosis, cytotoxic reactions (Fried 2016) and release soluble compounds including agglutinins and antimicrobial peptides (Ottaviani, 2006;Mitta et al, 2000). Chronic exposure of the T. pisana to Ag NPs caused alterations in hemocytes, such as micronuclei, binucleated cell and kidney-like nuclei (Radwan et al 2019). Also, B. glabrata exposed to CdTe quantum dot showed altered hemocytes binucleates, micronuclei, and apoptosis (de Vasconcelos Lima et al 2019).…”

Section: Discussionmentioning

confidence: 99%

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Toxicological evaluation of engineered layered double hydroxide nanomaterials to Biomphalaria alexandrina snails: a study on the mechanism of action

Abdo

Ibrahim

Hussein

et al. 2021

Preprint

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Layered double hydroxide (LDH) nanomaterials have recently become immense research area as it is used widely in industries. So, it's chance of their release into natural environment and risk assessment to non-target aquatic invertebrate increasing. So, the present study aimed to synthesize and confirme the crystalline formation of Co-Cd-Fe LDHs and Co-Cd-Fe /PbI2 (LDH), and then to investigate the toxic impact of the two LDH on the adult freshwater snails (Biomphalaia alexandrina). Results showed that Co-Cd-Fe /PbI2 LDH has more toxic effect to adult Biomphalaria than Co-Cd-Fe LDHs (LC50 was 56.4 mg/l, 72 h of exposure). The effect of LC25 (117.1 mg/l) of Co-Cd-Fe LDHs exposure on the embryo; showed suppression of embryonic development and induced embryo malformation. Also, it showed alterations in the tegmental architectures of the mantle-foot region of B. alexandrina snails as declared in scanning electron micrograph. Also, exposure to this sub lethal concentration caused abnormalities in hemocyte shapes and up-regulated IL-2 level in soft tissue. In addition, it decreased levels of non-enzymatic reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), caspase-3 activity and total protein content in significant manner. While, glutathione S-transferase (GST) activity was not affected by LDH exposure. It caused histopathological damages in both the hermaphrodite and digestive glands. Also, it has a genotoxic effect that was confirmed by alkaline comet assay. The results from the present study indicated that LDH has risk assessment on aquatic B. alexandrina snails and that it can be used as a biological indicator of water pollution with LDH

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Toxicological evaluation of engineered layered double hydroxide nanomaterials to Biomphalaria alexandrina snails: a study on the mechanism of action

Abdo

Ibrahim

Hussein

et al. 2021

Preprint

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“…Soil pollution is a central problem for human societies since it can affect the availability of soil for agriculture. It has been proposed that terrestrial gastropods can be good biomonitors and sentinels in soil pollution monitoring programs 13 – 19 . Among other, Pulmonata gastropods belonging to the Helix genus have been previously used to monitor trace metals, agrochemicals, urban pollution, and electromagnetic exposure 13 , 20 – 26 .…”

Section: Introductionmentioning

confidence: 99%

“…There is a lack of information concerning the molecular response to toxicants in Helix spp ., so any data will improve the battery of approaches to analyze toxicity. Oxidative and stress responses were the primary processes selected in this study since they are involved in the effects of several toxicants, including nanomaterials 19 , 38 , 39 . Oxidative stress implies ROS formation, which can damage DNA and lipids, among other effects.…”

Section: Introductionmentioning

confidence: 99%

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Effect of silver nanoparticles on gene transcription of land snail Helix aspersa

Turki

Younes

Sakly

et al. 2022

Sci Rep

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Silver nanoparticles (Ag-NPs) are extremely useful in a diverse range of consumer goods. However, their impact on the environment is still under research, especially regarding the mechanisms involved in their effect. Aiming to provide some insight, the present work analyzes the transcriptional activity of six genes (Hsp83, Hsp17.2, Hsp19.8, SOD Cu–Zn, Mn-SOD, and BPI) in the terrestrial snail Helix aspersa in the presence of different concentrations of Ag-NPs. The animals were exposed for seven days to Lactuca sativa soaked for one hour in different concentrations of Ag-NPs (20, 50, 100 mg/L). The results revealed that the highest concentration tested of Ag-NPs (100 mg/L) led to a statistically significant induction of the Hsp83 and BPI expression in the digestive gland compared to the control group. However, a trend to upregulation with no statistical significance was observed for all the genes in the digestive gland and the foot, while in the hemolymph, the trend was to downregulation. Ag-NPs affected the stress response and immunity under the tested conditions, although the impact was weak. It is necessary to explore longer exposure times to confirm that the effect can be maintained and impact on health. Our results highlight the usefulness of the terrestrial snail Helix aspersa as a bioindicator organism for silver nanoparticle pollution biomonitoring and, in particular, the use of molecular biomarkers of pollutant effect as candidates to be included in a multi-biomarker strategy.

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Nanomedicines: intervention in inflammatory pathways of cancer

Anwar

Naqvi

Shams³

et al. 2023

Inflammopharmacol

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Inflammation is a complex defense process that maintains tissue homeostasis. However, this complex cascade, if lasts long, may contribute to pathogenesis of several diseases. Chronic inflammation has been exhaustively studied in the last few decades, for its contribution in development and progression of cancer. The intrinsic limitations of conventional anti-inflammatory and anti-cancer therapies triggered the development of nanomedicines for more effective and safer therapies. Targeting inflammation and tumor cells by nanoparticles, encapsulated with active therapeutic agents, offers a promising outcome with patient survival. Considerable technological success has been achieved in this field through exploitation of tumor microenvironment, and recognition of molecules overexpressed on endothelial cells or macrophages, through enhanced vascular permeability, or by rendering biomimetic approach to nanoparticles. This review focusses on the inflammatory pathways in progression of a tumor, and advancement in nanotechnologies targeting these pathways. We also aim to identify the gaps that hinder the successful clinical translation of nanotherapeutics with further clinical studies that will allow oncologist to precisely identify the patients who may be benefited from nanotherapy at time when promotion or progression of tumor initiates. It is postulated that the nanomedicines, in near future, will shift the paradigm of cancer treatment and improve patient survival. Graphical abstract

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Responses of oxidative stress, genotoxicity and immunotoxicity as biomarkers inTheba pisanasnails dietary exposed to silver nanoparticles

Cited by 23 publications

References 75 publications

Toxicological evaluation of engineered layered double hydroxide nanomaterials to Biomphalaria alexandrina snails: a study on the mechanism of action

Toxicological evaluation of engineered layered double hydroxide nanomaterials to Biomphalaria alexandrina snails: a study on the mechanism of action

Effect of silver nanoparticles on gene transcription of land snail Helix aspersa

Nanomedicines: intervention in inflammatory pathways of cancer

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