Responsiveness of monkey skeletal muscle arteries to vasoconstrictor substances before and after cold storage.

Sinanović, Osman; Chiba, Shigetoshi

doi:10.1254/jjp.46.237

Cited by 9 publications

(12 citation statements)

References 21 publications

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“…In this study, we demonstrated that the order of vasoconstrictor responses of alpha adrenoceptor agonists in isolated dog lingual arteries was almost the same as those shown to occur in dog mesenteric arteries (16), dog femoral arteries (17) and branches of the skeletal muscle area of dog femoral arteries (18). NE (a mixed alpha-1 and alpha-2 ago nist) and PE (an alpha-1 agonist) produced a strong vasoconstriction in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 61%

“…Compared with other blood vessels which have been investi gated in this laboratory using the same method, the lingual arteries from both species showed the lowest sensitivity to KCI. Sinano vic and Chiba (24) proposed that a relatively small vasoconstriction response to KCl in skeletal muscle arteries may indicate the rela tive resistance of the cell membrane to the KCl depolarizing effect and consequently, less Ca++ influx from the extracellular space, or/and an existence of relatively voltage in sensitive Ca++ channels.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacological Features of Vascular Responses of Isolated Dog and Monkey Lingual Arteries to Vasoactive Substances

Škrbić

Chiba

1991

Japanese Journal of Pharmacology

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ABSTRACT-Using a perfusion technique of isolated vessels, vasoconstrictor re sponses to alpha adrenoceptor agonists (norepinephrine [NE], phenylephrine [PE], clonidine, xylazine and tyramine) and KCI were investigated in isolated, perfused dog and monkey lingual arteries. A stainless steel cannula was inserted into the lingual artery segment and perfused with Krebs-Henseleit solution at a constant flow rate. In dog lingual avteries, the agonists induced vasoconstrictions with the following order of potency: NE > PE > tyramine >> clonidine > xylazine > KCI. In monkey prepara tions, the order was NE > PE >> clonidine >_ tyramine > xylazine > KC1. In both preparations, NE and PE-induced constrictions were blocked by bunazosin (an alpha 1 adrenoceptor antagonist), but not influenced by midaglizole (a potent alpha-2 anta gonist). Diltiazem (a Ca entry blocker) significantly attenuated NE-induced vasocon strictions in dog lingual arteries, but did not significantly influence these in monkey preparations. These results suggest that: [1] these arteries contain mostly alpha-1 but scarcely any alpha-2 adrenoceptors; [2] in dog preparations, tyramine induced a marked vasoconstriction which may contribute to investigation on the mechanisms of catecholamine releases from sympathetic nerve terminals; and [3] different blocking effects of diltiazem may indicate that extracellular Ca + + influx may have varying de grees of importance in alpha-1 adrenoreceptor-mediated constrictions in different spe cies, although participation of an intracellular mechanism might not be ruled out.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Pharmacological Features of Vascular Responses of Isolated Dog and Monkey Lingual Arteries to Vasoactive Substances

Škrbić

Chiba

1991

Japanese Journal of Pharmacology

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“…Therefore, cloni dine might produce a vasoconstriction mediated via a, adrenoceptors but not a2-adrenoceptors in the canine splenic artery, although clonidine is thought to be a selec tive a2-adrenoceptor agonist. Using the same method, we have reported that clonidine induces a vasoconstriction in the canine intermediate auricular artery via a2-adrenocep tors (17) and that clonidine does not constrict the canine lingual artery, femoral artery and mesenteric arteries, although there are abundant a,-adrenoceptors in these ar teries (18,22,23). A higher responsiveness of the splenic artery to clonidine suggests that the characteristics of a, adrenoceptors in the splenic artery are different from the ones in other arteries.…”

Section: Effects Of Vasoactive Agentsmentioning

confidence: 98%

“…Since Hongo and Chiba (4) introduced the cannula insertion method in pharmacological and physiological studies, effects of vasoactive substances on the canine intermediate auricular, femoral, mesenteric, ophthalmic, basilar, coronary and lingual arteries had been reported by the use of this method (8,(16)(17)(18)(19)(20)(21)(22)(23). Observations on vasoconstrictive responses to a-adrenoceptor agonists, ATP and histamine indicate that the distributions of adrenergic, purinergic and histaminergic receptors in different arteries are not always same (16,17,(19)(20)(21).…”

Section: Effects Of Vasoactive Agentsmentioning

confidence: 99%

“…Several reports in dicated that there were a few discrepancies of pharma cological responses to vasoactive substances using the can nula insertion method (14,15). On the other hand, we have reported that the vasoconstrictive responses to a adrenoceptor agonists, ATP and histamine in different ar teries are not always same, which reflects the distributions of adrenergic, purinergic and histaminergic receptors in vascular smooth muscle cells (16)(17)(18)(19)(20)(21). Therefore, we in vestigated the discrepancy of vasoconstrictive responses to clonidine, and observed the vasoconstrictive responses to vasoactive agents and electrical nerve stimulation in iso lated and perfused canine splenic arteries.…”

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confidence: 91%

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Characteristics of the Responses of Isolated and Perfused Canine Splenic Arteries to Vasoactive Substances and to Periarterially Electrical Stimulation

Ren

Nakane

Chiba

1994

Japanese Journal of Pharmacology

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ABSTRACT-Pharmacological characteristics of the canine isolated splenic artery were investigated by the cannula insertion method for observing vascular responses to vasoactive agents and periarterial nerve stimulation. Four a-adrenoceptor agonists and tyramine induced vasoconstrictions in a dose-dependent manner, and the order of potency was noradrenaline (NA) > phenylephrine > clonidine > methoxamine > tyramine. Xylazine (a selective a2-adrenoceptor agonist) did not elicit any vasoconstriction. Several autacoids and KCl also constricted the splenic artery dose-dependently, and the order of potency was 5 hydroxytryptamine (5-HT) > ATP = histamine > KCI. The dose-response curves for clonidine and NA were shifted to the right by bunazosin (a selective a,-adrenoceptor antagonist), but were not affected by midaglizole (a selective a2-adrenoceptor antagonist). The parameters of electrical stimulation to elicit a clear and constant vasoconstriction were 0.2 msec of pulse duration, 6 V and 0.1 Hz. The vasoconstrictive responses to electrical stimulation at 6-12 V, 0.1-10 Hz and 0.2-1 msec of pulse duration were completely inhibited by tetrodotoxin (TTX) and strongly inhibited by guanethidine. The results in this study suggest that: 1) in contrast with other regional arteries, the canine splenic artery has an a 1-adrenoceptor-related and clonidine-sensitive vasoconstrictive response, 2) this artery has no functional postsynaptic a2-adrenocep tors, 3) it may be easier to observe the vascular responses to vasoactive agents in the isolated and perfused arterial segments, and 4) the isolated and perfused canine splenic artery is useful as a preparation to study the sympathetic nerve transmission.

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Vascular Tissue Preservation Techniques

Müller‐Schweinitzer¹

1994

The Human Brain Circulation

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Responsiveness of monkey skeletal muscle arteries to vasoconstrictor substances before and after cold storage.

Abstract: Abstract-The stainless steel

Cited by 9 publications

References 21 publications

Pharmacological Features of Vascular Responses of Isolated Dog and Monkey Lingual Arteries to Vasoactive Substances

Pharmacological Features of Vascular Responses of Isolated Dog and Monkey Lingual Arteries to Vasoactive Substances

Characteristics of the Responses of Isolated and Perfused Canine Splenic Arteries to Vasoactive Substances and to Periarterially Electrical Stimulation

Vascular Tissue Preservation Techniques

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