Restoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

“…The reduced body weight gains upon CoCl 2 exposure may be explained by the metabolic cost theory where the toxic stressors induce some metabolic changes that consume the organism's energy reserves to combat the effects of the toxicant or to activate repair mechanisms, resulting in an alteration of protein and carbohydrate metabolism [41]. On the other hand, the recorded increases in body weight gain in response to MOEE administration could be due to the desirable nutritional contents, including vitamins, amino acids, minerals, and fatty acids, besides various types of antioxidants including flavonoids, ascorbic acid, glucsinolates, carotenoids, and phenolics [25]. The phytochemical analysis of the MOEE used in the present study showed that the extract is rich in thymol that enhances the digestibility and antimicrobial efficiency against gut pathogens [42] and may be responsible for the advantageous influence of MO supplementation on animal performance.…”

“…Further, alteration in the glomerular filtration, which refrains proteins and cells from being released into the urine, leads to hypoproteinemia (as recorded in the present study). Another explanation for protein content depletion is the interceding protein catabolism as an energy reserve to counter the existence stress and activate repair mechanisms [25].…”

“…The selected dose of CoCl2 in this study was carried out based on the results of previous work of Awoyemi et al [29], where it induced tissue damage via oxidative stress, inflammation, and apoptosis in a dose-dependent manner. The ethanolic extract of MO leaves was found to increase the protective activity of the antioxidant system and slow the pathological development of tissue alterations, which was induced by xenobiotic exposure when administrated at the level of 400 mg/kg bw [11,25]. At the end of the experimental period, the final body weight of rats in all groups was measured to estimate the changes in body weight.…”

“…A wide degree of safety of different MO extracts was reported, such as for example the median lethal dose (LD 50 ) of alcoholic extract of MO leaves up to 5 gm/ kg body weight (bw) [21]. in vivo human and animals as well as in vitro studies proved that various extracts of MO leaves possess different therapeutic effects, such as anti-inflammatory, hypolipidemic, antioxidant, anti-diabetic, and chemoprotective (hepatic, cardiac, renal, and nervous) activities [11,[22][23][24][25].…”

Moringa oleifera Lam. extract rescues lead‐induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex

“…Although this family is native to India, Pakistan, and Nepal, it grows almost everywhere across the world, even in harsh environments. This plant has many beneficial pharmacological properties (Khalil et al., 2020); all of its parts, including the flowers, stem, and leaves have medicinal value (Mohamed et al., 2019). For instance, its leaves, which can be consumed raw, air‐dried, or cooked, are full of vitamins A and C, antioxidants (glucosinolates, anthocyanidins, phytosterols, and flavonoids), and proteins that can supplement nutritional deficiencies (Gopalakrishnan et al., 2016; Kandeil et al., 2020).…”