Restriction of Epstein-Barr virus-specific cytotoxic T cells by HLA-A, -B, and -C molecules

Chen, Benjamin P.; Lam, Valery; Kraus, Eric E.; DeMars, Robert; Sondel, Paul M.

doi:10.1016/0198-8859(89)90099-2

Cited by 18 publications

(9 citation statements)

References 20 publications

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“…A peptide derived from the gag protein of HIV-1 was found to be presented by HLA-Cw3 [42], and some EBV-specific CTL were shown to be restricted by HLA-C [43]. As shown above, the HLA-Cw*1601 allele is also the presenting element for antigen Ba recognized on the autologous melanoma cells by CTL 82/82 of patient MZ2.…”

Section: Discussionmentioning

confidence: 99%

“…The antigen recognized by CTL 82/82 was named MZ2-Ba. 43.TheTNFcontent of the supernatant of a co-culture expressed. the antigens recognized by autologous CTL clones as of 1500 CTL and 30000 target cells was estimated by testing its well as the gencsencoding some of these antigens are indicated for toxicity on WEHI-164 clone 13 cells.…”

Section: Hla-cw*1601 Typingmentioning

confidence: 99%

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Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

et al. 1994

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Human melanoma cell line MZ2-MEL expresses several antigens recognized by autologous cytolytic T lymphocyte (CTL) clones. We reported previously the identification of a gene, named MAGE-1, which codes for antigen MZ2-E which is presented by HLA-A1. Gene MAGE-1 is expressed in many tumors of several types but not in normal tissues except for testis. We show here that gene MAGE-1 directs the expression of another antigen recognized by CTL on the MZ2-MEL cells. This antigen, which was named MZ2-Bb, consists of MAGE-1-encoded peptide SAYGEPRKL bound to major histocompatibility molecule HLA-Cw*1601. The HLA-Cw*1601 allele was found to be expressed by 7 out of 99 individuals from a Caucasian population. Our results extend the range of tumor patients who could be eligible for immunization against MAGE antigens.

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Section: Discussionmentioning

confidence: 99%

Section: Hla-cw*1601 Typingmentioning

confidence: 99%

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

et al. 1994

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“…Apart from alloreactive, HLA-Cspecific T cells, only three examples have been reported: Epstein-Barr virus-specific, HLA-C-restricted T-cell recognition shown by two groups (10,11), recognition of a human immunodeficiency virus gag-derived peptide presented by , and recognition of viral peptides by HLA-C-restricted T cells from transgenic mice (13). One explanation for the rare occurrence of such T cells could be the relatively low expression of HLA-C molecules on cells, only (15,41,42).…”

Section: Discussionmentioning

confidence: 99%

“…Whether HLA-C molecules are also regularly associated with peptides has not been established (5). Although recognition of HLA-C molecules by alloreactive T cells has been demonstrated (6)(7)(8)(9), very few HLA-C-restricted T cells (10)(11)(12)(13) have been reported; most class I-restricted T cells directed against viral, tumor, or minor histocompatibility antigens are HLA-A or -B restricted. Thus, the function of HLA-C molecules is not well known.…”

mentioning

confidence: 99%

Allele-specific peptide ligand motifs of HLA-C molecules.

Falk

Rötzschke

Grahovac

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

116

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The consensus motifs of HLA-Cw3, -Cw4, -Cw6, and -Cw7 ligands were determined by pool sequencing. Together with information obtained by sequencing of some prominent individual peptides, the results indicate the following: (t) all four HLA-C molecules are associated with peptides. (i) These peptides adhere to allele-specific motifs that are similar to those of to HLA-A or -B molecules; they have a preferred length of nine amino acids and an anchor residue at the C terminus. (Mi) AU four HLA-C molecules analyzed exhibit related peptide motifs, although each ailelic product shows individual characteristics in fine specificity. (iv) Processing and origin of peptides appear not to be different from that of other class I molecules. (v) No obvious difference at C-terminal position 9 was present in the peptides isolated from the two dimorphic variants of HLA-C that determine dominant resistance to natural killer NKl-speciflc cells (HLA-Cw4, -Cw6) or to NK2-specific cells (HLA-Cw3, -Cw7) and that differ in two residues in or near the pocket at position 9.

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“…CD8 T-cell cytotoxicity assays were performed, as described previously. 13 PBMCs were primed against irradiated cells from the EBV-transformed 721 B-cell line. On days 10, 17, 24, and 31, priming of the cultures was repeated by adding irradiated 721 cells.…”

Section: Degranulation and Cytotoxicity Assaysmentioning

confidence: 99%

β2-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system

Ardeniz

Unger

Önay

et al. 2015

Journal of Allergy and Clinical Immunology

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Restriction of Epstein-Barr virus-specific cytotoxic T cells by HLA-A, -B, and -C molecules

Cited by 18 publications

References 20 publications

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601

Allele-specific peptide ligand motifs of HLA-C molecules.

β2-Microglobulin deficiency causes a complex immunodeficiency of the innate and adaptive immune system

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