Results from the Survey of Antibiotic Resistance (SOAR) 2009–11 in Vietnam

Vân, Phạm Hùng; Bình, Phạm Thái; Minh, Nguyen Hong; Morrissey, Ian; Torumkuney, D

doi:10.1093/jac/dkw069

Cited by 18 publications

(13 citation statements)

References 9 publications

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“…Given the assumption that most children would already have received antibiotics by the time they present to hospital, most doctors prefer using broad-spectrum antibiotics, although no benefit has been demonstrated in adults or children with community-acquired ‘pneumonia’ 30 31. Luckily, the use of third generation oral cephalosporins was limited, unlike other Asian settings where its use is common 32 33…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic use in children hospitalised with pneumonia in Central Vietnam

et al. 2020

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Background and objectivesExcessive use of antibiotics has been noted in children with respiratory tract infections in Vietnam, but antibiotic use in hospitalised children is poorly documented. Antibiotic use and direct healthcare costs in children hospitalised with pneumonia in central Vietnam were assessed.MethodsA prospective descriptive study of children under 5 years old admitted with a primary admission diagnosis of ‘pneumonia’ to the Da Nang Hospital for Women and Children over 1 year.ResultsOf 2911 children hospitalised with pneumonia, 2735 (94.0%) were classified as ‘non-severe’ pneumonia by the admitting physician. In total, 2853 (98.0%) children received antibiotics. Intravenous antibiotics were given to 336 (12.3%) children with ‘non-severe’ and 157/176 (89.2%) children with ‘severe’ pneumonia; those with ‘non-severe’ pneumonia accounted for 68.2% (336/493) of intravenous antibiotics given. Only 19.3% (95/493) of children on intravenous antibiotics were stepped down to an oral antibiotic. Cefuroxime was the preferred oral agent, and ceftriaxone was the preferred injectable agent. Hospital admission for oral antibiotics in ‘non-severe’ pneumonia was a major cost driver, with an average direct cost of US$78.9 per patient, accounting for 54.0% of the total hospitalisation cost in the study cohort. In addition, 336 (12.3%) children with non-severe pneumonia received intravenous antibiotics without indication, accounting for a further 23.2% of hospitalisation costs.ConclusionLimiting unnecessary hospitalisation and considering early intravenous to oral step down antibiotic will reduce direct health system costs and morbidity in children with respiratory tract infections in Vietnam.

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Section: Discussionmentioning

confidence: 99%

“…A recent survey in Vietnam confirmed excellent penicillin susceptibility in Streptococcus pneumoniae isolated from respiratory specimens, while cephalosporin and macrolide susceptibility was poor 33. This suggests that a high dose of amoxicillin remains an excellent antibiotic choice in paediatric pneumonia cases.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic use in children hospitalised with pneumonia in Central Vietnam

et al. 2020

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“…In order to select the optimal therapy for their patients, clinicians must be aware of changes in resistance patterns and the effectiveness of the antibiotics used to treat particular organisms over time. For this reason, a number of global antimicrobial surveillance programs, including STAR (Surveillance of Tedizolid Activity and Resistance; tedizolid), SOAR (Survey of Antibiotic Resistance; amoxicillin/clavulanic acid, cefuroxime, cefaclor, azithromycin and ofloxacin), ZAAPS (Zyvox R Annual Appraisal of Potency and Spectrum; linezolid) and TEST (Tigecycline Evaluation Surveillance Trial; tigecycline), have been initiated [27][28][29][30][31].…”

Section: Overview Of Testing Methodologymentioning

confidence: 99%

Susceptibility Testing and Reporting of New Antibiotics with a Focus on Tedizolid: An International Working Group Report

et al. 2017

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Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes. Selection of appropriate antimicrobials relies on accurate and timely antimicrobial susceptibility testing. However, the availability of clinical breakpoints and in vitro susceptibility testing often lags behind regulatory approval by several years for new antimicrobials. A Working Group of clinical/medical microbiologists from Brazil, Canada, Mexico, Saudi Arabia, Russia and the UK recently examined issues surrounding antimicrobial susceptibility testing for novel antibiotics. While commercially available tests are being developed, potential surrogate antibiotics may be used as marker of susceptibility. Using tedizolid as an example of a new antibiotic, this special report makes recommendations to optimize routine susceptibility reporting.

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“…As observed throughout the world, antimicrobial resistance is an increasing problem in Vietnam [ 16 ]. Particularly noteworthy are antibiotic-resistant organisms in hospital settings, including Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa [ 17 ], Streptococcus pneumoniae , Haemophilus influenzae [ 18 ], Escherichia coli , and Staphylococcus aureus [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Zingiber Species from Vietnam: Chemical Compositions and Biological Activities

Hương

Chung

Hương

et al. 2020

Plants

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Mosquito-borne diseases are a large problem in Vietnam as elsewhere. Due to environmental concerns regarding the use of synthetic insecticides as well as developing insecticidal resistance, there is a need for environmentally-benign alternative mosquito control agents. In addition, resistance of pathogenic microorganisms to antibiotics is an increasing problem. As part of a program to identify essential oils as alternative larvicidal and antimicrobial agents, the leaf, stem, and rhizome essential oils of several Zingiber species, obtained from wild-growing specimens in northern Vietnam, were acquired by hydrodistillation and investigated using gas chromatography. The mosquito larvicidal activities of the essential oils were assessed against Culex quinquefasciatus, Aedes albopictus, and Ae. aegypti, and for antibacterial activity against a selection of Gram-positive and Gram-negative bacteria, and for activity against Candida albicans. Zingiber essential oils rich in α-pinene and β-pinene showed the best larvicidal activity. Zingiber nudicarpum rhizome essential oil showed excellent antibacterial activity against Enterococcus faecalis, Staphylococcus aureus, and Bacillus cereus, with minimum inhibitory concentrations (MIC) of 2, 8, and 1 μg/mL, respectively. However, the major components, α-pinene and β-pinene, cannot explain the antibacterial activities obtained.

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Results from the Survey of Antibiotic Resistance (SOAR) 2009–11 in Vietnam

Cited by 18 publications

References 9 publications

Antibiotic use in children hospitalised with pneumonia in Central Vietnam

Antibiotic use in children hospitalised with pneumonia in Central Vietnam

Susceptibility Testing and Reporting of New Antibiotics with a Focus on Tedizolid: An International Working Group Report

Essential Oils of Zingiber Species from Vietnam: Chemical Compositions and Biological Activities

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