Results of Administration of Anterior Pituitary Adrenocorticotropic Hormone to a Normal Human Subject*†

Mason, Harold L.; Power, Marschelle H.; Rynearson, Edward H.; Ciaramelli, Letizia C.; LI, CHOH HAO; Evans, Herbert M.

doi:10.1210/jcem-8-1-1

Cited by 78 publications

(6 citation statements)

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“…However, the regulatory function of pituitary hormones was already well recognized and the effects of ACTH on endogenous adrenal corticosteroid production had been well characterized in humans. [12][13][14] Hench obtained ACTH-containing extracts of porcine pituitary from Dr F I G U R E 1 Erythrocyte sedimentation rate (ESR) as a function of time in Hench's case #6. The top panel shows data from the first three months of treatment.…”

Section: Foundational Studies Of the Immunomodulatory Properties Of Acthmentioning

confidence: 99%

Pituitary neuropeptides and B lymphocyte function

et al. 2021

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This review discusses the accumulated evidence that pro-opiomelanocortin (POMC) gene products as well as other pituitary neuropeptides derived from related genes (Proenkephalin, PENK; Prodynorphin, PDYN, and Pronociceptin, PNOC) can exert direct effects on B lymphocytes to modulate their functions. We also review the available data on receptor systems that might be involved in the transmission of such hormonal signals to B cells.

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Section: Foundational Studies Of the Immunomodulatory Properties Of Acthmentioning

confidence: 99%

Pituitary neuropeptides and B lymphocyte function

et al. 2021

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“…Glucocorticoids are produced by zF cells at a basal level, but can be stimulated by ACTH secreted from the anterior pituitary under stress 97–99 . In humans, cortisol is the main glucocorticoid produced by the adrenal cortex under normal conditions and its actions include mobilization of fats, proteins, and carbohydrates 100–102 .…”

Section: Structure and Function Of The Adult Adrenal Cortexmentioning

confidence: 99%

Development of Adrenal Cortex Zonation

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Rainey

et al. 2015

Endocrinology and Metabolism Clinics of North America

132

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“…Sodium is retained in amounts greater than one would expect from the amount of chloride retained, and some of it probably replaces potassium lost from the cells (3,4). 1 The expense of these studies was partly defrayed by grants from the Rockefeller Foundation, the National Advisory Cancer Council and the American Cancer Society on the recommendation of the Committee on Growth of the National Research Council. A bed supported by Mr. Edward Mallinckrodt, Jr., on the Metabolic Ward, was used for these studies.…”

Section: Itmentioning

confidence: 99%

Effects of 17-Hydroxy-Corticosterone (“Compound F”) in Man 12

Fourman¹,

Bartter²,

Albright³

et al. 1950

J. Clin. Invest.

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Itis not yet established whether the adrenal cortex normally secretes several hormones or just one hormone with different actions. The results of studies on adrenocorticotropic hormone (ACTH) (1-3) have on the whole been consistent with the hypothesis that the cortex produces three types of hormone: one affecting carbohydrate metabolism ("sugar" or "S" hormone), one affecting sodium and potassium metabolism ("salt" or "Na" hormone) and one with somatotropic and androgenic properties ("nitrogen" or "androgenic" hormone).As evidence for the first, the "sugar" hormone, ACTH produces the metabolic changes that one would expect from the combination of protoplasmic breakdown and glycogen deposition (3); it also produces glycosuria and hyperglycemia, and a fall in blood lymphocytes and eosinophils.As evidence for the second, the "salt" hormone, on the first day of giving ACTH, and often before the other changes are apparent, there is a large loss of potassium, quite out of proportion to the breakdown of protoplasm calculated from the nitrogen loss. Extracellular fluid (ECF) is also retained, as estimated from chloride changes. Sodium is retained in amounts greater than one would expect from the amount of chloride retained, and some of it probably replaces potassium lost from the cells (3,4).

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Results of Administration of Anterior Pituitary Adrenocorticotropic Hormone to a Normal Human Subject*†

Cited by 78 publications

References 0 publications

Pituitary neuropeptides and B lymphocyte function

Pituitary neuropeptides and B lymphocyte function

Development of Adrenal Cortex Zonation

Effects of 17-Hydroxy-Corticosterone (“Compound F”) in Man 12

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