Results of neoadjuvant therapy followed by esophagectomy for patients with locally advanced thoracic esophageal squamous cell carcinoma

Abstract

Background: For patients diagnosed with locally advanced esophageal cancer, neoadjuvant therapy followed by surgery is the most common approach. However, randomized trials resulted in inconsistent conclusions. We conducted this retrospective study to evaluate the influence of neoadjuvant therapy on postoperative events and the influence on disease-free survival (DFS) and overall survival (OS). Methods:We retrospectively reviewed all of the patients underwent surgery following neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma (ESCC) during January 1st, 2013 and December 31st, 2015 in Fudan University Shanghai Cancer Center (FUSCC). Prognostic factors for DFS and OS were identified by univariate and multivariate analyses.Results: A total of fifty patients were included. Regarding postoperative morbidities, pneumonia and leakage occurred in 9 (18.0%) and 6 (12.0%) patients, respectively. For the whole patients, the 1-, 2-, 3-year DFS and OS rates were 57.0%, 48.0%, 42.0% and 86.0%, 73.0%, 62.0%, respectively. Lung metastasis and mediastinal node involvement were the most common relapse patterns. Univariate and multivariate analyses confirmed ypTNM stage as an independent prognostic factor for both DFS and OS; while leakage was an independent prognostic factor for DFS. Conclusions: Neoadjuvant therapy did not increase postoperative morbidities but did achieve favorable survival. The ypTNM stage was an independent prognostic factor for both DFS and OS. Long-term survival needs further investigation.

WAVE3 upregulation in esophageal squamous cell carcinoma and its effect on the migration of human esophageal cancer cell lines in vitro

“…although the diagnostic and therapeutic strategies for malignant tumors have improved in recent years, the association between tumors and clinicopathological parameters has not yet been determined (6,7,9). at present, the migration mechanism mediated by WaVe3 has not been reported.…”

“…Patients with ec typically have a 5-year survival rate of 20-25%, even after radical resection, which is caused by >90% of patients with ec being diagnosed at the advanced stages, when the available treatment strategies are no longer optimal (7,8). additionally, early diagnostic techniques used for ec, including X-ray angiography, exfoliative cytology and endoscopy, have complicated clinical operations and are often inaccurate; therefore, the techniques cannot be used for routine screening (6,(9)(10)(11). With the continuous development of molecular tumor markers, the detection, simplicity, effectiveness and reliability of using peripheral blood serum has aided in the early diagnosis and treatment of patients with tumors (12,13).…”

Survival comparison between radical surgery and definitive chemoradiation in 267 esophageal squamous cell carcinomas in a single institution: A propensity-matched study

“…The most appropriate management of esophageal cancer is still inconclusive. Locally advanced esophageal cancer usually has a poor prognosis due to high rate of local recurrence in spite of very intense management of radical surgery with or without postoperative adjuvant chemotherapy [ 1 , 2 ]. According to the National Comprehensive Cancer Network (NCCN) practice guidelines, either preoperative CRT, definitive CRT with doses of 50–50.4 Gy only for patients who decline surgery, or esophagectomy are considered as standard treatments in esophageal squamous cell carcinoma [ 24 ].…”

“…Recent reports on esophagectomy showed a great improvement in the perioperative outcomes and survival achieved [ 4 ]. Although the 3-year overall survival (OS) rate after treatment with aggressive resection alone for esophageal cancer remains less than 35%, it has improved up to around 60% after treatment with aggressive resection with/without perioperative chemotherapy [ 2 – 3 ].…”

Inhibitory effect of microRNA‑455‑5p on biological functions of esophageal squamous cell carcinoma Eca109 cells via Rab31

“…Esophageal carcinoma is a common malignant tumor of the digestive tract, mainly comprising squamous cell carcinoma and adenocarcinoma, that is typically associated with poor patient prognosis ( 1 , 2 ). In China, esophageal carcinoma is has a high incidence and is the fourth most common of all malignant tumors ( 3 ).…”