Results of surgical treatment of patients with T3 non-small cell lung cancer

Prognostic Factors in Resected T3 Non-Small Cell Lung Carcinoma: Perineural Invasion as a New Prognostic Factor

“…Downey [17] reported a five-year survival rate for R0 cases of 32 % and of 4% for R1, and noted that the difference was statistically significant. Nakahashi [19] reported similar results supporting Downey's view. In contrast, Riquet [18] reported a 29.3 % five-year survival rate for R0 cases and 20 % for R1.…”

Special Treatment Issues in Non-small Cell Lung Cancer

“…36,42,47,48,51,[55][56][57][58] Adjuvant radiation in patients who received incomplete resection did not result in long-term survival, 44,47,56 and local recurrence rates of 30% to 40% at the site of a positive margin were seen, despite the use of radiation (dose not reported). 44,58 Some controversy remains about whether an en bloc resection of chest wall (vs parietal pleura only) is required for adequate resection of those tumors in which only the parietal pleura is involved. 59 There are no randomized data to answer this question, but retrospective data from most studies showed better survival for complete en bloc resections.…”

Outcomes after treatment of 17 378 patients with locally advanced (T3N0–2) non-small-cell lung cancer†

“…Similarly, several studies have shown that, in patients treated with incomplete resection, adjuvant radiation does not significantly improve survival [4,[18][19][20]. Furthermore, high local recurrence rates of 30-40% are seen when radiation is used to treat positive surgical margins [4,18,21]. In addition, the role of induction radiation prior to surgery for T3 tumours larger than 7 cm has been questioned, with Moreno et al failing to show improved survival compared with surgery alone, while another small single-centre study demonstrated improved survival [22,23].…”