Resveratrol and Reproductive Health

Novaković, R; Rajković, Jovana; Gostimirović, M.; Gojkovic-Bukarica, Ljiljana; Radunović, Nebojša

doi:10.3390/life12020294

Cited by 28 publications

(27 citation statements)

References 84 publications

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“…No RSV toxicity has been reported in studies ranging from 14 days to 3 months of RSV administration and a dose range of 15 mg to 5 g [ 127 ]. There are studies that reported mild adverse effects such as headaches, dizziness, epididymitis, nausea, diarrhea, and abdominal discomfort, but only at higher doses (2.5 and 5.0 g) [ 6 , 127 , 133 ]. Other adverse effects reported at 5 g of micronized resveratrol (SRT501) include chills, lethargy, rash, skin irritation, and vascular flushing [ 2 , 134 ].…”

Section: Resveratrol Supplementationmentioning

confidence: 99%

The Role of Resveratrol in Eye Diseases—A Review of the Literature

et al. 2022

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Resveratrol (3,5,4′-trans-trihydroxystilbene) is a polyphenolic phytoalexin belonging to the stilbene family. It is commonly found in grape skins and seeds, as well as other plant-based foods. Oxidative stress and inflammation play a key role in the initiation and progression of age-related eye disorders (glaucoma, cataracts, diabetic retinopathy, and macular degeneration) that lead to a progressive loss of vision and blindness. Even though the way resveratrol affects the human body and the course of many diseases is still the subject of ongoing scientific research, it has been shown that the broad spectrum of anti-inflammatory and neuroprotective properties of resveratrol has a beneficial effect on eye tissues. In our research, we decided to analyze the current scientific literature on resveratrol, its possible mechanisms of action, and its therapeutic application in order to assess its effectiveness in eye diseases.

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Section: Resveratrol Supplementationmentioning

confidence: 99%

The Role of Resveratrol in Eye Diseases—A Review of the Literature

et al. 2022

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“…Ao associar a fisiopatologia da endometriose e os benefícios do resveratrol à saúde espera-se a eficácia no tratamento da doença, principalmente no controle do processo proliferativo, inflamatório e reprodutivo (Novakovic et al, 2022;Halpern, et al, 2015). Diversas alterações metabólicas ocorrem para intensificar a atividade proliferativa da doença, sendo observados alguns ensaios experimentais e clínicos.…”

Section: O Papel Do Resveratrol No Tratamento De Endometrioseunclassified

“…As propriedades benéficas do resveratrol do sistema imunológico sob o endométrio advém de uma possível estimulação da molécula SIRT1, na qual, induz as respostas metabólicas antioxidantes e o melhor funcionamento mitocondrial a partir da inibição da inflamação mediada pelo TNF-α (Novakovic et al, 2022;Taguchi et al, 2014). Um ensaio clínico in vitro observou uma supressão da IL-8 na presença ou ausência do TNF-α a partir da ativação endógena da SIRT1 após a aplicação do resveratrol em células endometriais (Taguchi et al, 2014).…”

Section: O Papel Do Resveratrol No Tratamento De Endometrioseunclassified

“…Além disso, uma dieta rica em nutrientes e compostos anti inflamatórios pode melhorar o estado de inflamação e o estresse oxidativo em pacientes com dores crônicas (Rondanelli et al, 2018), em essencial, com fontes de resveratrol devido à melhora do perfil inflamatório (Koushki et al, 2020) da saúde reprodutiva (Novakovic et al, 2022). Entretanto, não há consenso sobre como utilizar o resveratrol no manejo da endometriose.…”

Section: Introductionunclassified

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O potencial efeito do resveratrol no tratamento da endometriose

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A endometriose é uma desordem ginecológica caracterizada pela presença de tecido endometrial fora da cavidade uterina relacionado com predisposição genética, dependência de estrogênio, resistência à progesterona e inflamação. A teoria da menstruação retrógrada, formulada por Sampson, é a etiologia cientificamente mais aceitável devido mecanismos semelhantes que ocorreram em mulheres saudáveis. Entretanto, diversas outras teorias foram levantadas com diferentes focos fisiopatológicos. A patogênese da doença contribui para um desequilíbrio imunológico, culminando no aumento da expressão de mediadores inflamatórios, angiogênicos e alterações em diversas vias metabólicas. O resveratrol é um polifenol que tem sido amplamente estudado pelos seus benefícios no controle de mediadores inflamatórios. Nesta revisão, nós resumimos os achados mais recentes que interligam os efeitos do resveratrol e possíveis melhorias na sintomatologia da doença alvo. Estudos experimentais e in vitro mostraram resultados benéficos quando avaliados em modelos endometrióticos. No entanto, os mesmos resultados não foram obtidos em humanos, especialmente quando avaliaram os limiares de dor antes e depois da suplementação do resveratrol. Em conclusão, os resultados para a prática clínica ainda são inconclusivos.

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“…Phytoestrogen resveratrol (R) is an analog of natural sex hormones and an estrogen receptor agonist [ 16 ]. R (3,4′,5-trihydroxystilbene) is a plant polyphenol occurring in grapes, berries, and nuts.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms

et al. 2022

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Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However, R bioavailability and pharmacokinetics are still problematic under oral supplementation. We used an experimental vaginal gel with R and hyaluronic acid (HA) to improve bioavailability and pharmacokinetic properties. The study aimed to assess the impact of vaginal R-HA gel on the reproductive system in ovariectomized rats. Methods: The study was carried out on Wistar female rats. It investigated the body weight, tail temperature, vaginal pH, estrogen and progesterone blood levels, and immunohistochemical biomarkers (COX2, Casp-3, Bcl-2, and VEGF). Animals were divided into control animals; ovariectomized rats (OVX); and OVX group treated with vaginal 0.5% R-HA gel (0.5%, 0.1 mL, daily 28 days). Results: The R-HA gel’s therapeutic effect was manifested by slowing weight gain by 17% (p < 0.001), less pronounced symptom of fever at the root of the tail by 9% (p < 0.001) and lowering the vaginal pH to 4.4–4.5 compared with OVX rats. The anti-inflammatory effect and the reduction of COX-2 expression in vagina were accompanied by antiapoptotic impact of RA-H on endometrium, associated with the decreased Casp-3 expression (p < 0.001) and elevated Bcl-2 score in endometrial glands (p = 0.01). Together with enhanced VEGF expression in endometrial glands (p < 0.001) and stromal cells (p = 0.007), these changes prevented endometrial atrophy (p < 0.001) after ovariectomy. Thus, this study substantiates the feasibility of developing an innovative topical drug with R and HA for treating hypoestrogenic disorders.

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Resveratrol and Reproductive Health

Cited by 28 publications

References 84 publications

The Role of Resveratrol in Eye Diseases—A Review of the Literature

The Role of Resveratrol in Eye Diseases—A Review of the Literature

O potencial efeito do resveratrol no tratamento da endometriose

Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms

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