Resveratrol blocks atherosclerosis development by inhibiting IL-1β in macrophages induced by cholesterol

Xie, Yilin; Wang, Zhaoxia; Lin, Hongfei; Pan, Ya‐Jun; Wang, Lianyun; Yan, Zhiqiang; Qiao, Zhongdong; Han, Zhihua

doi:10.2298/abs181129039x

Cited by 2 publications

(1 citation statement)

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“…Recent studies have also shown that the anti-atherosclerotic effect of berberine may be through the activation of the Sirt1-TFEB or AMPK/mTOR signaling pathway to induce autophagy and inhibit the inflammatory response of macrophages [ 96 , 97 ]. In addition to inducing autophagy, resveratrol could inhibit the inflammation of Ana-1 murine macrophages caused by cholesterol, inhibit the expression of IL-1β in macrophages and enhance the reverse cholesterol transport of macrophages [ 98 ]. An in vivo study also shows that ApoE −/− mice with 24 weeks of oral resveratrol eliminate intestinal fatty acids and monoglycerides accumulation in atherosclerotic lesions [ 99 ].…”

Section: Tuning Macrophages For Atherosclerosis Therapymentioning

confidence: 99%

Tuning macrophages for atherosclerosis treatment

Fang

Xiao

et al. 2022

Regenerative Biomaterials

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Atherosclerosis is a chronic inflammatory vascular disease and one of the leading causes of death worldwide. Macrophages play an important role in atherosclerosis in the inflammatory response, cell-cell communications, plaque growth, and plaque rupture in atherosclerotic lesions. Here we review the sources, functions, and complex phenotypes of macrophages in the progression of atherosclerotic, and discuss the recent approaches in modulating macrophage autophagy and phenotypic transformation for atherosclerosis treatment. We then focus on the drug delivery strategies that target macrophages or use macrophage membrane-coated particles to deliver therapeutics to the lesion sites. These biomaterial-based approaches to target, modulate, or engineer macrophages have broad applications for disease therapies and tissue regeneration.

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