Resveratrol enhances TNF-α production in human monocytes upon bacterial stimulation

Gualdoni, Guido A.; Kovarík, J; Hofer, Johannes; Dose, Franziska; Pignitter, Marc; Doberer, Daniel; Schmitz, Peter; Somoza, Veronika; Wolzt, Michael; Zlabinger, Gerhard J.

doi:10.1016/j.bbagen.2013.09.009

Cited by 46 publications

(41 citation statements)

References 35 publications

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“…NF-κB, signaling is described as one of the major transcriptional regulators of TNF-α expression (16). Gualdoni et al have also reported that treatment with resveratrol increases NF-κB expression in human monocytes in a dose-dependent manner (14). In our study, parallel to TNF-α mRNA level, NF-κB mRNA level also increased in resveratrol treated groups, indicating that enhanced TNF-α production in the groups was caused by triggering NF-κB, signaling.…”

Section: Discussionsupporting

confidence: 76%

“…Our previous studies reported leptin treatment of the I/R group caused a marked decrease in the TNF-α values compared to I/R alone in rat bladder tissues (13). Gualdoni et al showed that the use of resveratrol increased the level of TNF-α soon after application (14). However, the molecular mechanisms and interaction between TNF-α and these two agents at the level of cellular pathways have not been clarifi ed.…”

Section: Introductionmentioning

confidence: 99%

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The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats

Erkasap¹,

Erkasap²,

Bradford³

et al. 2017

BLL

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OBJECTIVE: Our study aimed to investigate the possible modifying effects of leptin and combined use of resveratrol on rat renal I/R injury and their relationship on signal pathways and apoptosis-related mechanisms. BACKGROUND: Renal ischemia-reperfusion (I/R) injury is an important cause of acute renal failure. METHODS: Male Sprague Dawley rats were divided into 5 groups: Control, I/R, I/R+leptin, I/R+resveratrol and I/R+leptin+resveratrol. Leptin (10 μg/kg BW) was administered (i.p.) 30 min prior to I/R. Resveratrol was administered by gavage at 20 mg/kg BW per d for 12 d prior to I/R. The left renal artery was exposed to 1 h of ischemia and 1 h of reperfusion. RESULTS: Resveratrol treatment alone increased TNF-α, TNF-α R1, NF-κB, SIRT-1, STAT1 and STAT3 mRNA levels and decreased caspase 3 protein levels. Leptin treatment alone signifi cantly decreased the caspase 3 protein levels. The combined use of resveratrol and leptin signifi cantly increased STAT3, and caspase 3 mRNA levels, and decreased the caspase 3 protein levels. Apoptosis was signifi cantly decreased especially in the leptin and leptin+resveratrol groups. CONCLUSION: The present study suggest that a combined use of resveratrol and leptin has preventive and regulatory effects on renal I/R injury; the mechanism involves decreasing apoptosis, likely by altering the JAK/ STAT pathway and SIRT1 expression (Fig. 8, Ref. 24). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats

Erkasap¹,

Erkasap²,

Bradford³

et al. 2017

BLL

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“…Varying incubation times with toll-like receptor (TLR) agonists and incubation with supraphysiologic concentrations of resveratrol in previous studies in humans and rodents may partially explain the profound difference in cytokine responses (Gao et al, 2001;Qureshi et al, 2012;Youn et al, 2005). In fact, a recent study in human peripheral blood mononuclear cells found that resveratrol resulted in increased TNF production and decreased IL-10 production following stimulation with toll like receptor (TLR)-2 and 4 agonists due to both increased NF-B signaling and stimulation of p105 phosphorylation, an alternative NF-B signaling pathway (Gualdoni et al, 2014). This study was performed in a manner similar to the canine study, with PBMC preincubation with resveratrol followed by incubation of leukocytes with PAMPs (Gualdoni et al, 2014).…”

Section: Discussionmentioning

confidence: 92%

“…In fact, a recent study in human peripheral blood mononuclear cells found that resveratrol resulted in increased TNF production and decreased IL-10 production following stimulation with toll like receptor (TLR)-2 and 4 agonists due to both increased NF-B signaling and stimulation of p105 phosphorylation, an alternative NF-B signaling pathway (Gualdoni et al, 2014). This study was performed in a manner similar to the canine study, with PBMC preincubation with resveratrol followed by incubation of leukocytes with PAMPs (Gualdoni et al, 2014). Another investigation in the rat model of hepatocellular carcinoma found that resveratrol reversed hepatic inflammatory cytokine suppression, resulting in increased TNF, IL-1␤, and IL-6 (Mbimba et al, 2012).…”

Section: Discussionmentioning

confidence: 97%

Resveratrol decreases oxidative burst capacity and alters stimulated leukocyte cytokine production in vitro

Woode

Axiak‐Bechtel

Tsuruta

et al. 2015

Veterinary Immunology and Immunopathology

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“…Resveratrol-3- O -glucuronide, resveratrol-4′- O -glucuronide and resveratrol-3- O -sulfate are metabolites of resveratrol. These conjugates have been detected in human plasma after oral administration of resveratrol [21]. After 15 h stimulation with isorhapontigenin or rhapontigenin, SIRT1 mRNA expression was upregulated in THP-1 cells (Figure 5).…”

Section: Resultsmentioning

confidence: 99%

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

et al. 2014

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Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-methyl piceatannol, was detected as a piceatannol metabolite in rat plasma. To elucidate the function of piceatannol and its metabolites, we investigated the expression of sirtuin 1 (SIRT1) in THP-1 monocytic cells after treatment with piceatannol and its metabolites, and compared their effects with those of resveratrol and its metabolites. Piceatannol and resveratrol upregulated the expression levels of SIRT1 mRNA and SIRT1 protein. An extract of passion fruit seeds, which contained high levels of piceatannol, also upregulated SIRT1 mRNA expression. As for the metabolites, isorhapontigenin upregulated SIRT1 mRNA expression, whereas resveratrol glucuronides and sulfate did not affect SIRT1 expression. These findings indicate that after intake of piceatannol, not only piceatannol itself, but also its metabolite, isorhapontigenin, contributed to the upregulation of SIRT1 expression.

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Resveratrol enhances TNF-α production in human monocytes upon bacterial stimulation

Cited by 46 publications

References 35 publications

The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats

The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats

Resveratrol decreases oxidative burst capacity and alters stimulated leukocyte cytokine production in vitro

Piceatannol and Its Metabolite, Isorhapontigenin, Induce SIRT1 Expression in THP-1 Human Monocytic Cell Line

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