Resveratrol prevents oxidative stress and inhibition of Na+K+-ATPase activity induced by transient global cerebral ischemia in rats

Simão, Fabrício; Matté, Aline; Matté, Cristiane; Soares, Flávia Mahatma Schneider; Wyse, Ângela T. S.; Netto, Carlos Alexandre; Salbego, Christianne Gazzana

doi:10.1016/j.jnutbio.2010.07.013

Cited by 82 publications

(50 citation statements)

References 53 publications

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“…Similar finding was obtained by Simao et al in another experimental model of transient global cerebral ischemia due to four cerebral vessels occlusion. (29) The current study showed a highly significant negative correlation between serum MDA levels and TAC in ischemia/reperfusion rats, which suggested increased utilization by ROS as a contributing factor to low TAC in rats with cerebral ischemia. (30) Also there is negative correlation between neurological deficit score and both serum and brain tissue levels of MDA and NO.…”

Section: Discussionsupporting

confidence: 54%

Oxidative / Nitrosative Stress in Rats Subjected to Focal Cerebral Ischemia / Reperfusion

Awooda

Lutfi

et al. 2015

IJHS

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Section: Discussionsupporting

confidence: 54%

Oxidative / Nitrosative Stress in Rats Subjected to Focal Cerebral Ischemia / Reperfusion

Awooda

Lutfi

et al. 2015

IJHS

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“…To assess ROS formation, 2' ,7'-dichlorofluorescein diacetate (DCFH-DA; Sigma-Aldrich) was used as previously descried (21). Briefly, the hippocampus was isolated, homogenized using a manual glass homogenizer, and incubated with DCFH-DA (100 µM) at 37˚C for 30 min.…”

Section: Measurement Of Rosmentioning

confidence: 99%

Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Chao

Zhang

et al. 2015

Molecular Medicine Reports

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Abstract. The present study provided experimental evidence for the neuroprotective effects of quercetin using a rat model of global brain ischemic/reperfusion (I/R) injury. Pre-treatment with quercetin (5 or 10 mg/kg orally (p.o.); once daily) induced a dose-dependent reduction in I/R-induced hippocampal neuron cell loss, with 10 mg/kg/day being the lowest dose that achieved maximal neuroprotection. Administration of 10 mg/kg quercetin over at least 3 days prior to I/R was required to improve the survival rate of I/R rats. Fluorescence-assisted cell sorting, hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling indicated neuronal cell loss in the CA1 hippocampus. Rats that had undergone transient global cerebral ischemia for 15 min followed by 1 h of reperfusion exhibited a significant increase in reactive oxygen species (ROS) production in the hippocampus. The I/R-induced ROS overproduction in the hippocampus at 1, 12 and 24 h following I/R was significantly decreased by quercetin pre-treatment. Western blot analysis revealed that the neuroprotective effects of quercetin (5 and 10 mg/kg/day, p.o.) were associated with an upregulation of the I/R-induced suppression of B-cell lymphoma-2 (Bcl-2), Bcl extra large and survivin expression as well as phosphorylation of Bcl-2-associated death promoter. Furthermore, the neuroprotective effects of quercetin (5, 10 mg/kg/day) in the brain were associated with an upregulation of Akt signaling. These findings suggested that the inhibition of I/R-induced brain injury by quercetin likely involves a transcriptional mechanism to enhance anti-apoptotic signaling.

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“…It is widely accepted that increasing oxidative stress level is associated with several age-related degenerative diseases such as neurodegeneration and cognitive impairment [1][2][3][4] . In the absence of an effective therapy, brain ageing can increase the susceptibility to Alzheimer's disease, which is the most common cause of dementia 5 . From the report of the World Health Organization, there were nearly 36 million people who suffered from dementia in 2012 and this number will possibly be close to triple in 2050 6 .…”

Section: Introductionmentioning

confidence: 99%

Learning and memory enhancing effects of anthocyanin in black rice extract on cerebral ischaemia in mice

Kangwan¹,

Pintha²,

Preedapirom³

et al. 2015

ScienceAsia

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ABSTRACT:The protective effect of anthocyanins extracted from black rice against learning and memory impairment was investigated in mice. In a Morris water maze test, mice with transient cerebral ischaemia required a longer time to find the hidden platform than the sham-operated controls. Daily treatment of cerebral-ischaemia mice with black rice extracts (125, 250, and 500 mg/kg body weight) significantly decreased the escape latency and increased the percentage crossing the former platform quadrant in the probe trial. Furthermore, less lipid oxidation was found in the brains of cerebral-ischaemia mice fed with black rice extract. Overall, black rice extract supplementation could be advantageous in the protection against oxidative stress and oxidative damage in the brains of cerebral-ischaemia mice.

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Resveratrol prevents oxidative stress and inhibition of Na+K+-ATPase activity induced by transient global cerebral ischemia in rats

Cited by 82 publications

References 53 publications

Oxidative / Nitrosative Stress in Rats Subjected to Focal Cerebral Ischemia / Reperfusion

Oxidative / Nitrosative Stress in Rats Subjected to Focal Cerebral Ischemia / Reperfusion

Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Learning and memory enhancing effects of anthocyanin in black rice extract on cerebral ischaemia in mice

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