Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice

Jiang, Yixuan; Luo, Wenqiong; Wang, Bin; Wang, Xinyu; Gong, Ping; Yu, Xiong

doi:10.1016/j.lfs.2020.117422

Cited by 85 publications

(55 citation statements)

References 36 publications

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“…Resveratrol may play an important role in delaying the development of bone disease, especially age‐related bone function decline (Wang et al, 2017). Further studies have shown that resveratrol can reverse the effect of oxidative stress on bone in osteoporosis by reducing the oxidative stress level and activating SIRT1 and FoxO1 deacetylation in the models of OB oxidative damage induced by H 2 O 2 (Jiang et al, 2020). Besides this, resveratrol enhanced osteoblast mitotic phagocytosis by mediating SIRT1 and PI3K/AKT/mTOR signaling pathways and protected OB in osteoporosis rats (Yang et al, 2019; Zhao et al, 2018).…”

Section: Therapeutic Potential Of Autophagy In Bone Diseasementioning

confidence: 99%

“…Besides this, resveratrol enhanced osteoblast mitotic phagocytosis by mediating SIRT1 and PI3K/AKT/mTOR signaling pathways and protected OB in osteoporosis rats (Yang et al, 2019; Zhao et al, 2018). And in vivo, it was found that resveratrol prevented ovariectomy (OVX) bone loss and did not proliferate in the uterus, the results suggested that the compound is beneficial for the prevention and treatment of osteoporosis (Jiang et al, 2020).…”

Section: Therapeutic Potential Of Autophagy In Bone Diseasementioning

confidence: 99%

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The role of autophagy in bone homeostasis

Guo

Yang

et al. 2021

Journal Cellular Physiology

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Autophagy is an evolutionarily conserved intracellular process and is considered one of the main catabolism pathways. In the process of autophagy, cells are digested nonselectively or selectively to recover nutrients and energy, so it is regarded as an antiaging process. In addition to the essential role of autophagy in cellular homeostasis, autophagy is a stress response mechanism for cell survival. Here, we review recent literature describing the pathway of autophagy and its role in different bone cell types, including osteoblasts, osteoclasts, and osteocytes. Also discussed is the mechanism of autophagy in bone diseases associated with bone homeostasis, including osteoporosis and Paget's disease. Finally, we discuss the application of autophagy regulators in bone diseases. This review aims to introduce autophagy, summarize the understanding of its relevance in bone physiology, and discuss its role and therapeutic potential in the pathogenesis of bone diseases such as osteoporosis.

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Section: Therapeutic Potential Of Autophagy In Bone Diseasementioning

confidence: 99%

Section: Therapeutic Potential Of Autophagy In Bone Diseasementioning

confidence: 99%

The role of autophagy in bone homeostasis

Guo

Yang

et al. 2021

Journal Cellular Physiology

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“…a previous study revealed that Pic and resveratrol both improved ischemia and anoxia via upregulating HiF-1α expression, and downregulating c-Myc, egl-9 family hypoxia inducible factor 1 and β-catenin expression levels via the activation of Sirt1 (45). The nad + -dependent protein deacetylase Sirt1 serves a critical role in the inhibition of oxidative stress and suppression of apoptosis along with downstream signaling of the Foxo1 pathway (46). in the present study, Pic enhanced antioxidant activity and suppressed apoptosis in a dose-response manner, and the activity of the Sirt1/Foxo1 signaling pathway was upregulated simultaneously.…”

Section: Discussionmentioning

confidence: 98%

Piceatannol protects against cerebral ischemia/reperfusion‑induced apoptosis and oxidative stress via the Sirt1/FoxO1 signaling pathway

et al. 2020

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reperfusion is a critical therapeutic intervention used following acute ischemic stroke; however, it may cause cerebral ischemia/reperfusion injury (ciri) and aggravate brain damage. Piceatannol (Pic), a hydroxylated analog of resveratrol, has been reported to exhibit anti-inflammatory effects. However, the detailed molecular mechanisms and its effects on CIRI have not been sufficiently assessed, and, to the best of our knowledge, current methods of prevention of ciri are limited. The aim of the present study was to investigate the effects of Pic on improving neurological function in a mouse model of ciri. For the animal experiments, 8-week-old c57Bl/6 mice were raised and randomly grouped, and an in vivo model of ciri was established. Mice were administered a low (10 mg/kg/day) or high-dose (20 mg/kg/d) of Pic 1 h after ciri orally and once daily for the next 6 days. neurological dysfunction was assessed using a modified neurological severity score and a rotarod test 1 week after ciri establishment, and the cognitive status of the mice was assessed using a Morris water maze. Hematoxylin and eosin staining was used to evaluate the histopathological changes. The expression levels of sirtuin 1 (Sirt1), Foxo1, cleaved caspase-3 (cc-3), Bax and Bcl-2 were measured using western blotting. intracellular reactive oxygen species (roS) generation, antioxidant enzymes [superoxide dismutase, glutathione (GSH) peroxidase and catalase] and non-enzymatic antioxidants (GSH) were also detected using spectrophotometry. after inhibition of the Sirt1/Foxo1 pathway, a Tunel assay was used for the detection of apoptotic cells in vitro and in vivo. The co-localization of neuron-specific nuclear protein and CC-3 was assessing using immunofluorescent staining. Pic improved neurological functions and ameliorated hippocampal neuronal pathology following ciri. in addition, the expression levels of cc-3 and Bax and intracellular roS levels were increased, while levels of antioxidant and non-enzymatic enzymes were decreased in the mouse model of CIRI. Low and high doses of Pic significantly decreased roS production and the expression levels of apoptosis-related proteins, but increased antioxidant enzyme levels. However, a high-dose of Pic did not result in increased levels of non-enzymatic enzymes. Furthermore, low and high doses of Pic treatment significantly activated the Sirt1/FoxO1 pathway. Following inhibition of the Sirt1/Foxo1 pathway, the percentage of Tunel-positive cells and expression of cc-3 were increased, and cc-3 was enriched in neurons. The antioxidant effects of Pic were blocked by inhibition of Sirt1 in vitro and in vivo. in conclusion, these results suggested that Pic may exert a neuroprotective effect against in hippocampal neurons via the Sirt1/Foxo1 pathway.

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“…Resveratrol was demonstrated to exert bone protection through the suppression of osteoclast functions and the induction and differentiation of osteoblasts in both in vivo and in vitro studies. Resveratrol induced osteoblast differentiation by regulating autophagy and modulating the Sirt1/Runx-2/Fox-O1 and PI3K/AKT/mTOR signaling pathways, therefore, ameliorating bone loss in osteoporotic animal models [181][182][183][184]. It was also shown to induce osteoblastic MC3T3-E1 cells differentiation via the induction of the calcineurin/NFATc1 signaling pathway [185].…”

Section: Resveratrolmentioning

confidence: 99%

Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

et al. 2021

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Osteoarthritis (OA) is a complex degenerative disease in which joint homeostasis is disrupted, leading to synovial inflammation, cartilage degradation, subchondral bone remodeling, and resulting in pain and joint disability. Yet, the development of new treatment strategies to restore the equilibrium of the osteoarthritic joint remains a challenge. Numerous studies have revealed that dietary components and/or natural products have anti-inflammatory, antioxidant, anti-bone-resorption, and anabolic potential and have received much attention toward the development of new therapeutic strategies for OA treatment. In the present review, we provide an overview of current and emerging natural-product-based research treatments for OA management by drawing attention to experimental, pre-clinical, and clinical models. Herein, we review current and emerging natural-product-based research treatments for OA management.

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Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice

Cited by 85 publications

References 36 publications

The role of autophagy in bone homeostasis

The role of autophagy in bone homeostasis

Piceatannol protects against cerebral ischemia/reperfusion‑induced apoptosis and oxidative stress via the Sirt1/FoxO1 signaling pathway

Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis

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