Resveratrol Supplementation Gender Independently Improves Endothelial Reactivity and Suppresses Superoxide Production in Healthy Rats

Söylemez, Sibel; Sepici, Aylin; Akar, Fatma

doi:10.1007/s10557-009-6198-z

Cited by 37 publications

(25 citation statements)

References 36 publications

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“…It is postulated that Res probably reduces the deleterious effect of oxidative stress in living cells due to its ability to 1) compete with co-enzyme Q and decrease mitochondrial ROS production, 2) scavenge superoxide radicals, 3) inhibit lipid peroxidation induced by Fenton reactions, and 4) regulate the expression of antioxidant co-factors and enzymes (Pervaiz & Holme 2009). In addition, some studies demonstrated that Res inhibits NADPH oxidase activity and expression, which is a major contributor to superoxide radical production causing local oxidative stress (Soylemez et al 2009, Spanier et al 2009). Along with a decrease in lipid peroxidation, resveratrol also induced a small but significant increase in protein and a higher increment (3 .…”

Section: Discussionmentioning

confidence: 99%

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Franco¹,

Moura²,

Koury³

et al. 2010

Journal of Endocrinology

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Resveratrol (Res) has been associated with protective effects against oxidative stress. This study evaluated the effect of Res over lipid peroxidation, antioxidant defense, hepatic sirtuin 1 (SIRT1), which up-regulates antioxidant enzymes, and copper/zinc superoxide dismutase (Cu/Zn SOD) in adult offspring whose mothers were protein restricted during lactation. Lactating Wistar rats were divided into control (C) group, which were fed a normal diet (23% protein), and low-protein and high-carbohydrate (LPHC) group, which were fed a diet containing 8% protein. After weaning (21 days), C and LPHC offspring were fed a normal diet until they were 180 days old. At the 160th day, animals were separated into four groups as follows: control, controlCRes, LPHC, and LPHCCRes. Resveratrol was given for 20 days (30 mg/kg per day by gavage). LPHC animals showed a higher total antioxidant capacity (TAC) without change in lipid peroxidation and SIRT1 expression. The treatment with Res increased TAC only in the control group without effect on lipid peroxidation and SIRT1. LPHC animals treated with Res had lower lipid peroxidation and higher protein and mRNA expression of SIRT1 without any further increase in TAC. No significant difference in liver Cu/Zn SOD expression was observed among the groups. In conclusion, maternal protein restriction during lactation programs the offspring for a higher antioxidant capacity, and these animals seem to respond to Res treatment with a lower lipid peroxidation and higher hepatic SIRT1 expression that we did not observe in the Res-treated controls. It is probable that the protective effect can be attributed to Res activating SIRT1, only in the LPHC-programed group.

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Section: Discussionmentioning

confidence: 99%

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Franco¹,

Moura²,

Koury³

et al. 2010

Journal of Endocrinology

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“…Resveratrol has vasoprotective effects in several experimental models due to suppression of NADPH oxidase and activation of SIRT1-dependent mechanisms [7,9,10]. In healthy rats, resveratrol was found to increase endothelial function by suppressing NAD(P)H-dependent superoxide production [8,11]. Moreover, resveratrol improves endothelial relaxation to acetylcholine by increasing levels of eNOS mRNA and eNOS phosphorylation in obese and type 2 diabetic mice [9,12].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits

Akar

Pektaş

Tufan

et al. 2011

Cardiovasc Drugs Ther

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“…However, relaxations of vessels isolated from normotensive animals were augmented by resveratrol. A similar effect of resveratrol on vessels isolated from normotensive animals had been examined in Wistar rats [16] but not in Sprague-Dawley rats [5]. Thus, these results represented that the effect of resveratrol on the endotheliumdependent relaxation was related to animal species and hypertension models.…”

Section: Discussionmentioning

confidence: 66%

“…ADMA is an endogenous competitive inhibitor of NO synthase and increased level of ADMA causes NO reduction in different types of hypertension [16,19,22]. However, the blood ADMA level was not determined in DOCA salt-induced hypertension of rats.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

et al. 2014

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Hypertension is a risk factor for the cardiovascular diseases. Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited. Resveratrol decreases blood pressure in animal models of hypertension. This study researched the mechanisms behind the effects of resveratrol on hypertension. Hypertension was induced by using the deoxycorticosterone acetate (DOCA)-induced (15 mg/kg twice per week, subcutaneously) salt-sensitive hypertension model of Wistar rats. Hypertension caused a decrease in endotheliumdependent relaxations of the isolated thoracic aorta. Resveratrol treatment (50 mg/l in drinking water) prevented DOCA salt-induced hypertension, but did not improve endothelial dysfunction. Plasma nitric oxide (NO), asymmetric dimethylarginine (ADMA), total antioxidant capacity (TAC) and hydrogen sulfide (H 2 S) levels were not changed by DOCA salt application. However, treatment of resveratrol significantly decreased ADMA and increased TAC and H 2 S levels. NO level in circulation was not significantly changed by resveratrol. DOCA salt application and resveratrol treatment also caused an alteration in the epigenetic modification of vessels. Staining pattern of histone 3 lysine 27 methylation (H3K27me3) in the aorta and renal artery sections was changed. These results show that preventive effect of resveratrol on DOCA salt-induced hypertension might due to its action on the production of some blood biomarkers and the epigenetic modification of vessels that would focus upon new aspect of hypertension prevention and treatment.

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Resveratrol Supplementation Gender Independently Improves Endothelial Reactivity and Suppresses Superoxide Production in Healthy Rats

Abstract: Our results suggest that resveratrol supplementation gender independently could improve the capacity of endothelial function and suppression of oxidative stress under physiological conditions. Resveratrol ingestion indicates a potential for cardiovascular health promotion.

Cited by 37 publications

References 36 publications

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits

Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

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