Retention of transforming growth factor β1 using functionalized dextran-based hydrogels

Cyclodextrin/dextran based hydrogels prepared by cross-linking with sodium trimetaphosphate

“…A similar decrease of the hydrogel SR has been reported for dextran (M w = 40,000 g mol −1 ) cross-linked with STMP feed ratio varying from 3 to 50% (Maire et al, 2005). The dextran molecular weight also influences the swelling properties: at a STMP feed ratio around 10%, SR was found to be of the order of 60 (Maire et al, 2005), 39 (this work) and 10 (Abed et al, 2011) for M w 40,000, 70,000 and 200,000 g mol −1 , respectively.…”

“…The dextran molecular weight also influences the swelling properties: at a STMP feed ratio around 10%, SR was found to be of the order of 60 (Maire et al, 2005), 39 (this work) and 10 (Abed et al, 2011) for M w 40,000, 70,000 and 200,000 g mol −1 , respectively. At a fixed STMP feed ratio, the hydrogel SR increases with NaOH concentration, with a variation close to one order of magnitude as the NaOH concentration varies between 1 and 2.5 mol L −1 .…”

“…Such hydrogels would combine the properties of both STMP crosslinked hydrogels and cyclodextrins, namely a better loading and a controlled release of hydrophobic drugs. Dextrans alone (Maire, Logeart-Avramoglou, Degat, & Chaubet, 2005), functionalized dextrans (Maire et al, 2005) or dextran/pullulan blends (Abed et al, 2011;Autissier et al, 2010;San Juan et al, 2009), have already been cross-linked with STMP to form hydrogel systems. Additionally, we have shown in a previous work that STMP can cross-link ␤CDs leading to water-soluble polymers (Wintgens, Dalmas, Sébille, & Amiel, 2013).…”

The evaluation of a small-diameter polysaccharide-based arterial graft in rats

“…Despite the lack of full endothelialisation on the graft luminal surface, we did not observe any extensive thrombosis. Nevertheless, addition for instance of some angiogenic growth factor directly into these grafts is possible [27] and could enhance endothelial cell coverage on its internal surface.…”

Controlled Oxidation of Dextran for Evolution of Polyether Segment Bearing Pendant Carboxyl Groups for Corrosion Inhibition Applications

“…12 At present, chemical modification of dextran is widely investigated for biomedical applications. [13][14][15][16][17][18][19][20][21][22][23][24] Periodate oxidation of dextran is known to give polymeric dialdehydes with the elimination of formates. [25][26][27] However, products from further oxidation with hypohalites, 28 possibly polymeric dicarboxylates, have not been characterized yet.…”