Retinopathy of Prematurity

Brown, Robert T.; Melvin, Brenda; Fletcher-Janzen, Elaine

doi:10.1002/9780470373699.speced1785

Cited by 8 publications

(13 citation statements)

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“…ROP is considered a disorder of retinal blood vessel development in preterm infants of low birth weight [ 64 ]. It was estimated that a global number of 184.700 children and 14,9 million preterm neonates developed ROP in the year 2010, and the incidence of ROP was 68% among neonates weighting <1.251 g [ 65 , 66 ].…”

Section: Retinopathy Of Prematuritymentioning

confidence: 99%

Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations

Guarnera,

Valente,

Pasquini

et al. 2024

Journal of Ophthalmology

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Congenital malformations of the eye represent a wide and heterogeneous spectrum of abnormalities that may be part of a complex syndrome or be isolated. Ocular malformation severity depends on the timing of the causative event during eye formation, ranging from the complete absence of the eye if injury occurs during the first weeks of gestation, to subtle abnormalities if the cause occurs later on. Knowledge of ocular malformations is crucial to performing a tailored imaging protocol and correctly reporting imaging findings. Together with the ophthalmologic evaluation, imaging may help frame ocular malformations and identify underlying genetic conditions. The purpose of this pictorial review is to describe the imaging features of the main ocular malformations and the related ophthalmologic findings in order to provide a clinico-radiological overview of these abnormalities to the clinical radiologist. Sight is a crucial sense for children to explore the world and relate with their parents from birth. Vision impairment or even blindness secondary to ocular malformations deeply affects children’s growth and quality of life.

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Section: Retinopathy Of Prematuritymentioning

confidence: 99%

Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations

Guarnera,

Valente,

Pasquini

et al. 2024

Journal of Ophthalmology

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“…ROP, which was originally named retrolental fibroplasia, is a proliferative retinal blood vessel disease that can lead to visual impairment of varying severity [ 13 , 14 ]. It is characterized by abnormal growth of blood vessels in the retina of premature newborns, especially those undergoing oxygen therapy [ 15 ], and with BW <1500 g, in which case the incidence rate is approximately 60% [ 7 ]. It is a multifactorial disease that is very common in premature newborns, with various perinatal factors and interventions having been associated with an increased risk of developing ROP, including MV, oxygen therapy, red blood cell (RBC) transfusions, RDS, BPD, anemia, IVH, necrotizing enterocolitis, sepsis, and multiple pregnancies [ 7 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Nasal Continuous Positive Airway Pressure on Retinopathy of Prematurity in Preterm Newborns: A Comparative Analysis with Mechanical Ventilation and High-Flow Nasal Cannula Therapy

Cioboata,

Manea,

Costescu

et al. 2024

Med Sci Monit

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Background Retinopathy of prematurity (ROP), originally described as retrolental fibroplasia, represents an abnormal growth of blood vessels in the premature retina that can occur in response to oxygen therapy. The association between ROP and invasive mechanical ventilation has been widely studied in the literature; however, the relationships between different types of ventilation and ROP have not been as well documented. This study aimed to compare the association of ROP incidence with mechanical ventilation (MV), nasal continuous positive airway pressure (nCPAP), and high-flow nasal cannula (HFNC) therapies in 130 pre-term infants with gestational ages <32 weeks. Material/Methods The study includes 130 premature newborns, out of which 54 underwent MV therapy, either alone or in combination with nCPAP or HFNC therapy, 63 underwent nCPAP therapy, either alone or in combination with MV or HFNC therapy, and 23 underwent HFNC therapy, either alone or in combination with MV or nCPAP therapy. The relationships between ROP and the 3 types of ventilation were analyzed by univariate followed by multivariate logistic regression. Results When adjusting for covariates, only nCPAP and birth weight were significantly associated with ROP, the former being a strong risk factor, with an adjusted odds ratio (AOR) of 7.264 (95% CI, 2.622–20.120; P <0.001), and the latter being a weak protective factor, with an AOR of 0.998 (95% CI, 0.996–0.999; P <0.05). Conclusions The results showed nCPAP was a strong ROP risk factor, birth weight was a weak ROP protective factor, and MV and HFNC were not significantly associated with increased ROP risk.

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“…Retinopathy of prematurity (ROP) is a disease of retinal vascular and capillary proliferation affecting preterm infants undergoing oxygen therapy. 1 ROP is one the major problem of neonates having premature gestational age which could lead to visual impairment and complete blindness. It is the major cause of major cause of childhood blindness.…”

Section: Introductionmentioning

confidence: 99%

“…4 ROP results from oxygen requirement which in turn results in pathologic growth of vessels in the developing retina that may lead to permanent damage to the retina as well as retinal detachment and macular folds. 1 Severity of ROP is associated with duration of oxygen therapy. 5,6 Early diagnosis and early management can help in preventing this major cause of blindness.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Retinopathy of Prematurity in Premature Neonates Visiting Sir Gangaram Hospital Lahore

Rauf¹,

Saigol²,

Chauhan³

et al. 2023

PJMHS

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Background: Retinopathy of prematurity (ROP) is a serious problem which affects the premature infants. It is becoming a public health issue in developing countries like Pakistan. Antenatal visits, delivery and NICU management plays an important role in prevention of ROP. Objective: The aim of this study was to find out the prevalence of retinopathy of prematurity in premature neonates visiting Sir Ganga Ram hospital Lahore. Study Design: observational study. Settings: Study was carried out in Out-patient of Ophthalmology Department, A public sector Sir Ganga Ram Hospital, Lahore Pakistan. Duration: The duration of the study was one year from September 2020 to August 2021. Methods: All the preterm babies referred from pediatric department were part of study. A total of 160 babies were examined in this study. The data was presented in the form of frequency and percentages using SPSS software. Results: In this study out of 160 patients 75(46.87%) were male and 85(53.12%) were females. The prevalence of retinopathy of prematurity was observed in 43(26.87%) babies. Weight of patients less than 1kg was 11(25.58%) between 1-1.5 kg was noted in 28(65.11%) patients and >2 kg weight was noted in 4(9.30%) patients. Babies with ROP, 23(53.48%) recovered without any intervention, 9(20.93%) required intervention and recovered after 3 months follow up, 6(13.95%) kept under observation and recovered after 4 months and 5(11.62%) babies lost follow up. Practical implication: this study will help in early diagnosis and prevention of disease and help to formulate and introduce newer guidelines for prevention, early identification and prompt treatment starting from basic levels to prevent development of ROP of any stage. Conclusion: The study concluded that the prevalence of retinopathy of prematurity in premature neonates visiting Sir Ganga Ram hospital Lahore is 27%. Keywords: Retinopathy of Prematurity(ROP), Neonates, Preterm, screening, blindness

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Retinopathy of Prematurity

Cited by 8 publications

References 1 publication

Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations

Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations

Effect of Nasal Continuous Positive Airway Pressure on Retinopathy of Prematurity in Preterm Newborns: A Comparative Analysis with Mechanical Ventilation and High-Flow Nasal Cannula Therapy

Prevalence of Retinopathy of Prematurity in Premature Neonates Visiting Sir Gangaram Hospital Lahore

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