RETRACTED ARTICLE: Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors

Abstract

Common chemotherapeutic agents such as vincristine often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is refractory to common analgesics and represents a challenging clinical issue. Angelicae dahuricae radix is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the active component(s) that attribute to the analgesic action have not been identified. This work described the anti-hyperalgesic effect of one coumarin component, auraptenol, in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. We reported that auraptenol dose-dependently reverted the mechanical hyperalgesia in mice within the dose range of 0.05–0.8 mg/kg. In addition, the anti-hyperalgesic effect of auraptenol was significantly blocked by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). Within the dose range studied, auraptenol did not significantly alter the general locomotor activity in mice. Taken together, this study for the first time identified an active component from the herbal medicine angelicae dahuricae radix that possesses robust analgesic efficacy in mice. These data support further studies to assess the potential of auraptenol as a novel analgesic for the management of neuropathic pain.

Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells

“…The main components of Angelicae dahuricae radix are reported to be volatile oil and ingredients of coumarin, including imperatorin, isoimperatorin and cnidilin, and these active ingredients of Angelicae dahuricae radix may explain its multiple functions (13). Previous studies have shown that auraptenol, a major coumarin component from Angelicae dahuricae radix, had a robust antinociceptive effect in a chronic neuropathic pain mouse model (1).…”

“…It has a strong scent, and its leaves are used to make incense (1). Angelicae dahuricae radix is the dried root of Angelica dahurica Bentham et Hooker and Angelica dahurica (Fisch.…”

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy

“…The highest dose of auraptenol (0.8 mg/kg, i.p.) totally suppressed the mechanical hyperalgesia without affecting the general locomotor activity [22].…”

Synergic stimulation of serotonin 5-HT1A receptor and α2-adrenoceptors for neuropathic pain relief: Preclinical effects of 2-substituted imidazoline derivatives

“…treatment. The doses of gabapentin, WAY 100635 and yohimbine were chosen on the basis of previously published results Wang et al, 2013;Vergelli et al, 2015).…”