RETRACTED ARTICLE: Cell-specific delivery of messenger RNA and microRNA by recombinant MS2 virus-like particles carrying cell-penetrating peptide

Sun, Ying; Yin, Guoxin

doi:10.1007/s00253-014-6274-6

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2015

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“…Lentiviral, adenoviral and adeno-associated viral (AAVs) vectors expressing miRNA antagonists or mimics have proven to be effective delivery systems in various cancer models [ 58 ]. Importantly, cell-specific moieties can be engineered onto the viral capsid to enhance specificity uptake by cancer cells [ 59 ]. Non-integrating AAVs were successfully used as vehicles for miRNA replacement therapy in liver cancer [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

MiRNA-based therapeutic intervention of cancer

2015

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MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs.

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Section: Introductionmentioning

confidence: 99%