RETRACTED ARTICLE: Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia

Ahmad, Niyaz; Naqvi, Atta Abbas; Alam, Aftab; Ashafaq, Mohammad; Rub, Rehan Abdur; Ahmad, Farhan Jalees

doi:10.1080/21691401.2017.1337024

Cited by 69 publications

(38 citation statements)

References 32 publications

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“…For co-surfactants selection, combination of Tween-80 with PEG-400 resulted in a very clear nanoemulsion. It is supported by research work of Ahmad et al and Sahni et al [10,35], where the use of hydrophilic co-surfactant resulted in a clear microemulsion. A very low zeta potential was noted here, however it is quite expected because the net surface charge for a nanoemulsion droplets decreases with the use of non-ionic surfactant as reported by McClements et al [36].…”

Section: Screening Of Excipientsmentioning

confidence: 79%

“…For in vitro drug release study of the developed formulations, pretreated dialysis membrane (pore size 2.4 nm, mol. weight cut off $12-14 kDa) was used [10,25]. The release medium comprised of; phosphate buffer: ethanol in a ratio of 7:3, pH 6.4 with a total volume of 100 whereas the set up for release study was maintained at 37 ± 1 C with a stirring for 6 h at 100 rpm.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

“…Nose-to-brain drug delivery system has been the focus for many researchers in recent years whereby a number of advantages have been exploited for this route such as bypass for blood brain barrier (BBB) and hepatic first pass metabolism, a non-invasive route and ease of administration [9,10]. In addition the added advantages of nano-emulsion, i.e.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED ARTICLE: Impact of ultrasonication techniques on the preparation of novel Amiloride-nanoemulsion used for intranasal delivery in the treatment of epilepsy

Ahmad

Alam

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Screening Of Excipientsmentioning

confidence: 79%

Section: In Vitro Drug Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED ARTICLE: Impact of ultrasonication techniques on the preparation of novel Amiloride-nanoemulsion used for intranasal delivery in the treatment of epilepsy

Ahmad

Alam

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…Likewise, quercetin treatment in murine genetic models of muscle dysfunction accompanied by motor impairments has also been effective [30]. Other models of brain injury, such as ischemia or delivery of neurotoxins, have been used to demonstrate beneficial protective effects of quercetin treatment on motor performance, including rotarod and grip strength [31][32][33][34]. In a recent study, Zhu et al [35] found that the combination of quercetin and dasatinib acted as a senolytic drug-that is, one that promotes apoptosis of senescent cells.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Glycosides Improve Motor Performance and Muscle Weight in Adult Mice

Kanzaki¹,

Takemoto²,

Ono³

et al. 2019

J Nutr Food Sci

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Male C57BL/6J (B6) mice aged 24 weeks were provided two concentrations (1.5 or 3.0 g/L) of quercetin glycosides (QG) in drinking water over the subsequent 24 weeks. The objective was to determine if QG could improve motor function during early stages of aging. No sustained significant differences in body composition or food intake were noted to confirm the safety of QG treatment. Treated mice had significantly improved performance in grip strength and rotarod tests but not in treadmill performance. The functional benefits were reflected in muscle morphology with increased wet weights of a selected group of muscles (quadratus femoris, gastrocnemius, tibialis anterior, and soleus) in treated mice. Thus, it would appear that long-term oral treatment with QG can safely and effectively improve selected elements of motor performance and increase muscle mass during the early stages of aging.

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“…100 Likewise, Ahmad and coworkers, developed quercetin loaded mucoadhesive intranasal nanoemulsion to treat cerebral ischemia and studied the targeting efficiency as well as the therapeutic efficiency using the rat model. 101 Further, the same group of authors investigated the competence of nanoemulsion for brain targeting of therapeutics. They prepared safranal, an anti-oxidant, loaded mucoadhesive nanoemulsion for intranasal administration to treat cerebral ischemia.…”

Section: Nanoemulsionmentioning

confidence: 99%

<p>Recent expansions of novel strategies towards the drug targeting into the brain</p>

Alexander¹,

Agrawal²,

Uddin³

et al. 2019

IJN

124

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The treatment of central nervous system (CNS) disorders always remains a challenge for the researchers. The presence of various physiological barriers, primarily the blood–brain barrier (BBB) limits the accessibility of the brain and hinders the efficacy of various drug therapies. Hence, drug targeting to the brain, particularly to the diseased cells by circumventing the physiological barriers is essential to develop a promising therapy for the treatment of brain disorders. Presently, the investigations emphasize the role of different nanocarrier systems or surface modified target specific novel carrier system to improve the efficiency and reduce the side effects of the brain therapeutics. Such approaches supposed to circumvent the BBB or have the ability to cross the barrier function and thus increases the drug concentration in the brain. Although the efficacy of novel carrier system depends upon various physiological factors like active efflux transport, protein corona of the brain, stability, and toxicity of the nanocarrier, physicochemical properties, patient-related factors and many more. Hence, to develop a promising carrier system, it is essential to understand the physiology of the brain and BBB and also the other associated factors. Along with this, some alternative route like direct nose-to-brain drug delivery can also offer a better means to access the brain without exposure of the BBB. In this review, we have discussed the role of various physiological barriers including the BBB and blood-cerebrospinal fluid barrier (BCSFB) on the drug therapy and the mechanism of drug transport across the BBB. Further, we discussed different novel strategies for brain targeting of drug including, polymeric nanoparticles, lipidic nanoparticles, inorganic nanoparticles, liposomes, nanogels, nanoemulsions, dendrimers, quantum dots, etc. along with the intranasal drug delivery to the brain. We have also illustrated various factors affecting the drug targeting efficiency of the developed novel carrier system.

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RETRACTED ARTICLE: Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia

Abstract: This study supports a significant role for QMNE in terms of high brain-targeting potential and formulation efficiency due to ease of access and effective targeting in brain.

Cited by 69 publications

References 32 publications

RETRACTED ARTICLE: Impact of ultrasonication techniques on the preparation of novel Amiloride-nanoemulsion used for intranasal delivery in the treatment of epilepsy

RETRACTED ARTICLE: Impact of ultrasonication techniques on the preparation of novel Amiloride-nanoemulsion used for intranasal delivery in the treatment of epilepsy

Quercetin Glycosides Improve Motor Performance and Muscle Weight in Adult Mice

<p>Recent expansions of novel strategies towards the drug targeting into the brain</p>

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