[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Lin, Erhu; Liu, Shuai; Xiang, Wei; Xie, Chaofan

doi:10.1155/2020/8386936

Cited by 14 publications

(9 citation statements)

References 40 publications

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“…Furthermore, we revealed the adsorption relationship between circITSN2 and miR-218-5p. It is reported that miR-218-5p could be absorbed and regulated by many circRNAs, like circEIF4G2 (Lin et al, 2020;Xu et al, 2020) and circSAMD4A (Wei et al, 2020). Our research also identified a novel upstream circRNA sponge for miR-218-5p in chicken muscle development.…”

Section: Discussionsupporting

confidence: 54%

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

Shen

Wei

Liu

et al. 2021

Front. Cell Dev. Biol.

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Circular RNA (circRNA) is a class of endogenous non-coding RNAs without 5′ and 3′ ends; an increasing number of studies show that circRNA is involved in skeletal muscle development. From our previous sequencing data, the circRNAome in breast muscle of two chicken lines with a distinct rate of muscle development, which included a fast muscle growing broiler (FMGB) and a slow muscle growing layer (SMGL), we found a novel differentially expressed circRNA generated by intersectin 2 (ITSN2) gene (named circITSN2). We verified that circITSN2 is a skeletal muscle-enriched circRNA that promotes chicken primary myoblast (CPM) proliferation and differentiation. Further molecular mechanism analysis of circITSN2 in chicken myogenesis was performed, and we found circITSN2 directly targeting miR-218-5p. Besides, miR-218-5p inhibits CPM proliferation and differentiation, which is contrary to circITSN2. Commonly, circRNAs act as a miRNA sponge to alleviate the inhibition of miRNAs on mRNAs. Thus, we also identified that a downstream gene LIM domain 7 (LMO7) was inhibited by miR-218-5p, while circITSN2 could block the inhibitory effect of miR-218-5p by targeting it. Functional analysis revealed that LMO7 also accelerates CPM proliferation and differentiation, which was similar to circITSN2 but contrary to miR-218-5p. Taken together, these results suggested that circITSN2 promotes chicken embryonic skeletal muscle development via relieving the inhibition of miR-218-5p on LMO7. Our findings revealed a novel circITSN2/miR-218-5p/LMO7 axis in chicken embryonic skeletal muscle development, which expands our understanding of the complex muscle development regulatory network.

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Section: Discussionsupporting

confidence: 54%

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

Shen

Wei

Liu

et al. 2021

Front. Cell Dev. Biol.

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“…The knockdown of circEIF4G2 suppressed the proliferation, migration and invasion of cervical cancer cells by sponging miR‑218 7 . CircEIF4G2 was also found to promote the progression of osteosarcoma through sponging miR218 8 . It is known that miR‐218 plays a key regulatory role in multiple human cancers, while its influence on DN pathology remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR‐218

Wang

et al. 2020

J Cellular Molecular Medi

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Circular RNAs play essential roles in the development of various human diseases. However, how circRNAs are involved in diabetic nephropathy (DN) are not fully understood. Our study aimed to investigate the effects of circRNA circEIF4G2 on DN. Experiments were performed in the db/db mouse model of type 2 diabetes and NRK‐52E cells. We found that circEIF4G2 was significantly up‐regulated in the kidneys of db/db mice and NRK‐52E cells stimulated by high glucose. circEIF4G2 knockdown inhibited the expressions of TGF‐β1, Collagen I and Fibronectin in high glucose‐stimulated NRK‐52E cells, which could be rescued by miR‐218 inhibitor. Knockdown of SERBP1 reduced the expression of TGF‐β1, Collagen I and Fibronectin in HG‐stimulated NRK‐52E cells. In summary, our findings suggested that circEIF4G2 promotes renal tubular epithelial cell fibrosis via the miR‐218/SERBP1 pathway, presenting a novel insight for DN treatment.

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“… 250 – 253 The expression of circEIF4G2 and circITCH affects cell biological functions, such as cell proliferation, migration, and invasion, in OS. 251 , 252 Silencing of circ0005909 obviously decreases cell viability and cell clone capacity in OS cell lines. 253 Decreased expression of circ0001785 reduces cell proliferation and facilitates cell apoptosis in OS.…”

Section: Tumors Of the Respiratory And Musculoskeletal Systemsmentioning

confidence: 97%

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Xue

Lü

et al. 2021

Sig Transduct Target Ther

136

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Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays key roles in many biological and cellular processes, such as cell proliferation, growth, invasion, migration, and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is significantly associated with clinicopathological characteristics and plays an important role in the regulation of biological functions. In this review, we summarized the expression and biological functions of PI3K-AKT-related circRNAs in vitro and in vivo and assessed their associations with clinicopathological characteristics. We also further discussed the important role of circRNAs in the diagnosis, prognostication, and treatment of cancers.

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[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Cited by 14 publications

References 40 publications

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

A Novel Circular RNA circITSN2 Targets the miR-218-5p/LMO7 Axis to Promote Chicken Embryonic Myoblast Proliferation and Differentiation

Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR‐218

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

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