RETRACTED: Protective Effect of Xinmailong Injection on Rats With Myocardial Infarction

Zhang, Wei; Li, Kailiang; Ding, Yunchuan; Ren, Jiefeng; Wang, Haijun; Si, Quan

doi:10.3389/fphys.2020.595760

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Additionally, the activity of anti-oxidant enzyme superoxide dismutase was found to be increased. The lowering of the ST-T segment, which began within 5 minutes, persisted for more than 3 hours (71). The flavonoids extracted from propolis were found to improve cardiac function.…”

Section: The Role Of Anti-oxidants In the Management Of Angina And Myocardial Infarctionmentioning

confidence: 95%

The role of flavonoids in the prevention and management of cardiovascular complications: a narrative review

Chen¹,

Zhang²

2021

Ann Palliat Med

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Objective: Cardiovascular diseases (CVDs) are the world's leading cause of death, affecting an estimated 17.9 million people. CVDs have been the primary risk factor for mortality in developed countries. Smoking, hypertension, diabetes, abdominal obesity, psychological stressors, insufficient vegetable and fruit intake could significantly alleviate the burden of disease. The present review sought to document the antihypertensive, anti-arrhythmic, anti-anginal, and anti-infarction effects of flavonoids.Background: Cardiovascular disorders are the leading cause of death worldwide, affecting an estimated 17.9 million individuals. Strokes and heart attacks account for 4 out of every 5 deaths caused by cardiovascular disorders. Physical activity protects against a variety of chronic conditions at any age. A demographic program combined with a high-risk CVD prevention approach could dramatically minimize the disease burden in the coming years. By controlling weight and improving the body's use of insulin, physical activity decreases the risk of CVDs. Tobacco and smoking are other modifiable factors associated with the progression of cardiovascular disorders. Abnormal blood lipids are also linked to dietary habits.Daily flavonoid consumption is linked to a lower risk of heart disease. Flavonoids have been the subject of significant interest by experts in recent times due to wide spectrum of possible benefits they provide. polyphenolic compounds can be useful as adjunctive therapy for the management and cure of inflammatory diseases.Methods: Literature related to cardiovascular effects of flavonoids was assessed on important database like PubMed, Scopus, ScienceDirect. The outcomes of various studies were documented.Conclusions: Flavonoids are fairly soluble in physiological media and thus are a potential candidate for the possible management of cardiovascular and associated disorders. Alleviating the oxidative stress induced by reactive oxygen species using anti-oxidant-rich flavonoids could lower the chances of platelet hyperactivation, heart disease, discomfort, and fibrosis. Flavonoid intake on a daily basis has been linked to a lower risk of heart failure. Polyphenolic compounds have the ability to be used as an adjunctive therapy in the prevention and control of cardiovascular and inflammatory diseases. Flavonoids have a role in the management of coagulation disorders.

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Section: The Role Of Anti-oxidants In the Management Of Angina And Myocardial Infarctionmentioning

confidence: 95%

The role of flavonoids in the prevention and management of cardiovascular complications: a narrative review

Chen¹,

Zhang²

2021

Ann Palliat Med

View full text Add to dashboard Cite

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“…n order to investigate the effects of TXL ultrafine grinding on experimental myocardial infarction and platelet aggregation in rats, Zhang, Y.F. et al [ 194 ] randomly divided the rats into a sham surgery group, a model group, diltiazem, TXL, and thromboxane Lu. Then ligate the left anterior descending branch of the rat coronary artery to induce experimental myocardial infarction.…”

Section: The Mechanism Of Tongxinluo In Preventing and Treating Cardi...mentioning

confidence: 99%

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

Xin,

Wang,

Hou

et al. 2024

Heliyon

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Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

Yang,

Hong,

Guan

et al. 2024

Front. Pharmacol.

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Ischemic stroke (IS) is a highly lethal type of cardiovascular and cerebrovascular disease. Improving survival rates and promoting recovery in patients with IS pose significant challenges, however, recent research has identified the gut–brain axis as a therapeutic target. In this study, we evaluated the regulatory effect of Periplaneta americana (L.) extract (PAS840), which has established anti-inflammatory, antioxidant, and neuroprotective effects, on the gut microbiota using a rat model of temporary middle cerebral artery occlusion (tMCAO). We evaluated the protective effects of PAS840 on brain damage in IS rats through TTC (triphenyltetrazolium chloride), Nissl staining, and pathological section analysis. Additionally, we investigated the impact of PAS840 on the gut microbiota and metabolites using 16S rRNA sequencing, untargeted metabolomics of gut contents, and transcriptomics analyses of brain tissues to explore its mechanism of action. PAS840 intervention resulted in significant changes in the gut microbiota, including an increase in the abundance of probiotic flora, decrease in the abundance of harmful flora, and significant changes in metabolite profiles. It also attenuated brain damage, decreased platelet activity, inhibited oxidative stress and genes related to inflammation, and improved neurological function in rats. These findings suggest that PAS840 has preventive and therapeutic effects against IS via the gut–brain axis by regulating the gut microbiota and related metabolites. Accordingly, PAS840 is a candidate therapeutic drug for further research.

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RETRACTED: Protective Effect of Xinmailong Injection on Rats With Myocardial Infarction

Cited by 3 publications

References 15 publications

The role of flavonoids in the prevention and management of cardiovascular complications: a narrative review

The role of flavonoids in the prevention and management of cardiovascular complications: a narrative review

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

Investigation of the effects of Periplaneta americana (L.) extract on ischemic stroke based on combined multi-omics of gut microbiota

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