RETRACTED: Reversion of hepatic steatosis by exercise training in obese mice: The role of sterol regulatory element-binding protein-1c

Cintra, Dennys E.; Ropelle, Eduardo Rochete; Vitto, Marcelo F.; Luciano, Thais F.; Souza, Daniela R.; Engelmann, Julia; Marques, Scherolin O.; Lira, Fábio Santos; Pinho, Ricardo A.; Pauli, José Rodrigo; Souza, Cláudio Teodoro de

doi:10.1016/j.lfs.2012.08.002

Cited by 32 publications

(20 citation statements)

References 39 publications

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“…The silkworm pupae powder intake control group showed an increasing tendency. Considering the study results that after having obese rats exercise, the CPT-1 was increased by a significant degree [39] and that a high intensity intermittent exercise can also increase the CPT-1 [38], some of this study’s results can be explained. In addition, there emerged studies that reported a subsequent increase in the CPT-1 after feeding rats with an oil enriched in α-linoleic acid [31], and this can explain why the two groups that were fed with the silkworm pupae powder showed elevated levels of CPT-1.…”

Section: Discussionmentioning

confidence: 98%

Silkworm pupae powder ingestion increases fat metabolism in swim-trained rats

Ryu

2014

Journal of Exercise Nutrition and Biochemistry

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[Purpose]Many researchers are trying to solve the metabolic syndrome by utilizing a variety of nutritional control and exercise. Of those, silkworm pupae peptides are known to inhibit the synthesis of fat. Therefore, we examine the effect of fat metabolism by supplying silkworm pupae (SP) for 5-week in swim-trained rats.[Methods]Animals were divided into four groups as a group (n = 32) fed a normal diet (CO) with exercise training (CE); a group fed a silkworm pupa diet (SPC) with an exercise training (SPE), respectively.[Results]Abdominal fat pads (abdominal and epididymal) weight were lowest in SPE. The serum triglyceride, total cholesterol concentrations were lower in the SP and the SPE. HDL-cholesterol, however, was not different between groups. Liver AMPK (AMP-activated protein kinase) was increased in the CE and the SPE. Liver PPAR-α (Peroxisome proliferator-activated receptor alpha) was increased in the SPC and SPE. L-FABP (liver fatty acids binding protein) was increased by SP ingestion. Liver CPT-1 (carnitine palmitoyltransferase-1) protein expression was increased by exercise training only.[Conclusion]In the present study showed that the silkworm pupae intake and/or swimming exercise training activates fat metabolism to reduce the concentration of serum lipids. Thus, the silkworm pupae intake leads to a reduction in fat storage, this is considered to be effective in the inhibition of the metabolic syndrome.

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Section: Discussionmentioning

confidence: 98%

Silkworm pupae powder ingestion increases fat metabolism in swim-trained rats

Ryu

2014

Journal of Exercise Nutrition and Biochemistry

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“…Besides enhancing free fatty acid oxidation in mitochondria, physical activity, particularly chronic aerobic exercise, may also reduce hepatic lipogenesis. In a high fat-fed mouse model, treadmill exercise substantially decreases the expression of sterol regulatory element-binding protein-1c (SREBP1c), a transcription factor triggering triglyceride synthesis (8). Chronic consumption of high fat or high carbohydrate diet elevates levels of inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin-1β (IL-1β) (38).…”

Section: Beneficial Effects Of Exercise On Nafldmentioning

confidence: 99%

“…Exercise or physical activity has shown promising results in clinical studies as well as in experimental models of obesity and NAFLD management (5, 8). The beneficial effects of exercise on fatty livers have been recently attributed to widespread stimulation of autophagy during physical activity (18).…”

Section: Introductionmentioning

confidence: 99%

Exercise-Induced Autophagy in Fatty Liver Disease

Chun¹,

Lee²,

Yang³

et al. 2017

Exercise and Sport Sciences Reviews

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Hepatic steatosis prevails each year. Autophagy is integral in mitochondrial quality control and lipid homeostasis in the liver. No pharmacological strategies are currently available to reduce hepatic steatosis, but exercise has been known to improve clinical outcomes of chronic liver disease, particularly non-alcoholic fatty liver disease (NAFLD). Recent studies suggest that exercise may improve NAFLD through enhancing autophagy.

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“…Studies have demonstrated that physical exercise diminished the expression of genic transcription factors involved in lipid synthesis and increased lipolytic enzyme expression in eutrophic obese rats (Cintra et al, 2012) fed high-fat diets (42% Kcal) for two weeks (Yasari et al, 2010) and improved the mitochondrial functionality in genetically hyperphagic rats (accepted model of metabolic syndrome) (Rector et al, 2008b). Furthermore, in other studies, physical exercise improved the blood lipid profile, reduced body mass and visceral adiposity (Estadella et al, 2004), improved the glucagon action and (Charbonneau, Couturier, Gauthier, & Lavoie, 2005) insulin resistance condition (Marques, Motta, Torres, Aguila, & Mandarim-de-Lacerda, 2010).…”

Section: Discussionmentioning

confidence: 99%

Physical training at sub-threshold intensity reduces the prevalence of hepatic steatosis after high-fat diet in rats

Silva

Godois

Odashiro

et al. 2015

Motriz: rev. educ. fis.

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Abstract-The purpose of the present study was to evaluate the effects of swimming physical training with sub-threshold load on the prevalence of hepatic steatosis in Wistar rats fed high-fat diets (cafeteria or baru). After 2 months of cafeteria diet administration, the rats were separated into 6 groups: Sedentary or Trained Baru diet; Sedentary or Trained Cafeteria diet; Sedentary or Trained standard diet. The trained groups were subjected to swimming exercise at sub-threshold intensity (2% of body weight) during 8 weeks, 5x/week, 1h/day. The body weight and hepatohistological changes were analyzed. Sedentary groups fed high-fat diets presented higher body weight gain when compared to control trained group. The swimming training at the proposed intensity was able to prevent the hepatic steatosis in rats fed high-fat diets.Keywords: swimming exercise, sub-threshold intensity, high-fat diet, hepatic steatosis Resumo-"Treinamento físico na intensidade sub-limiar reduz a prevalência de esteatose hepática em ratos alimentados com dietas hiperlipídicas." O objetivo do presente estudo foi avaliar os efeitos do treinamento físico de natação com carga sub-limiar sobre a prevalência de esteatose hepática em ratos Wistar alimentados com dietas hiperlipidícas (cafeteria ou baru). Após dois meses de dieta cafeteria, os ratos foram separados em 6 grupos: Baru treinado ou sedentário; Cafeteria treinado ou sedentário; Controle treinado ou sedentário. Os grupos treinados foram submetidos ao exercício de natação em intensidade sub-limiar, durante 8 semanas, 5x/semana, 1h/dia. As alterações de peso corporal e histopatológicas foram analisadas. Os grupos sedentários alimentados com dietas hiperlipídicas apresentaram maior ganho de peso corporal se comparados ao grupo controle treinado. O treinamento de natação na intensidade proposta diminuiu a prevalência de esteatose hepática induzida por dietas hiperlipídicas.Palavras-chave: exercício de natação, intensidade sub-limiar, dieta hiperlipídica, esteatose hepáticaResumen-"Entrenamiento físico de intensidad sub-umbral reduce la prevalencia de esteatosis hepática en ratas alimentadas con hiperlipidemia dietas." El objetivo de este estudio fue evaluar los efectos de la natación de entrenamiento físico con la carga por debajo del umbral de la prevalencia de la esteatosis hepática en ratas alimentadas con dietas con hiperlipidemia (cafetería o baru). Después de dos meses de dieta de cafetería, las ratas se dividieron en 6 grupos: entrenados o sedentarios Baru, entrenados o Cafeteria sedentaria; Control entrenados o sedentario. Los grupos formados fueron sometidos a nadar ejercicio de intensidad por debajo del umbral durante 8 semanas, y 1 hora al día 5x/week. Se analizó el peso y la histopatología. Grupos

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RETRACTED: Reversion of hepatic steatosis by exercise training in obese mice: The role of sterol regulatory element-binding protein-1c

Abstract: Our study allows concluding that the reduction in SREBP-1c protein levels is associated with steatosis reversion induced by exercise training.

Cited by 32 publications

References 39 publications

Silkworm pupae powder ingestion increases fat metabolism in swim-trained rats

Silkworm pupae powder ingestion increases fat metabolism in swim-trained rats

Exercise-Induced Autophagy in Fatty Liver Disease

Physical training at sub-threshold intensity reduces the prevalence of hepatic steatosis after high-fat diet in rats

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