Retraction Note: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease

Lakkireddy, Maheshwar; Gadiga, Srikanth Goud; Malathi, Ravela; Karra, Madhu Latha; Ragini,; Chinapaka, Sangeetha; Baba, K. S. S. Sai; Kandakatla, Manohar

doi:10.1038/s41598-022-10830-8

Cited by 17 publications

(26 citation statements)

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“…Positive effects of daylight go beyond the effects through the eye’s retina: daylight upregulates vitamin D production and bone health (Wirz‐Justice et al, 2020) and has disinfectant properties including against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) disinfectant properties (Ratnesar‐Shumate et al, 2020). A recent study found that sunlight exposure increased COVID‐19 recovery rates (Asyary & Veruswati, 2020); another study showed that high pulse dose of vitamin D significantly reduced inflammatory markers in patients with COVID 19 without side‐effects (Lakkireddy et al, 2021). Hence, exposure to daylight is not only a factor of resilience during the pandemic, but also a probable remediating factor.…”

Section: Discussionmentioning

confidence: 99%

Outdoor daylight exposure and longer sleep promote wellbeing under COVID‐19 mandated restrictions

Korman

Tkachev²,

Reis

et al. 2021

Journal of Sleep Research

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Summary Light is an important regulator of daily human physiology in providing time‐of‐day information for the circadian clock to stay synchronised with the 24‐hr day. The coronavirus disease 2019 (COVID‐19) pandemic led to social restrictions in many countries to prevent virus spreading, restrictions that dramatically altered daily routines and limited outdoor daylight exposure. We previously reported that sleep duration increased, social jetlag decreased, and mid‐sleep times delayed during social restrictions (Global Chrono Corona Survey, N = 7,517). In the present study, we investigated in the same dataset changes in wellbeing and their link to outdoor daylight exposure, and sleep–wake behaviour. In social restrictions, median values of sleep quality, quality of life, physical activity and productivity deteriorated, while screen time increased, and outdoor daylight exposure was reduced by ~58%. Yet, many survey participants also reported no changes or even improvements. Larger reductions in outdoor daylight exposure were linked to deteriorations in wellbeing and delayed mid‐sleep times. Notably, sleep duration was not associated with outdoor daylight exposure loss. Longer sleep and decreased alarm‐clock use dose‐dependently correlated with changes in sleep quality and quality of life. Regression analysis for each wellbeing aspect showed that a model with six predictors including both levels and their deltas of outdoor daylight exposure, sleep duration and mid‐sleep timing explained 5%–10% of the variance in changes of wellbeing scores (except for productivity). As exposure to daylight may extenuate the negative effects of social restriction and prevent sleep disruption, public strategies during pandemics should actively foster spending more daytime outdoors.

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Section: Discussionmentioning

confidence: 99%

Outdoor daylight exposure and longer sleep promote wellbeing under COVID‐19 mandated restrictions

Korman

Tkachev²,

Reis

et al. 2021

Journal of Sleep Research

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“…Sun exposure also increases the recovery rate of COVID-19 patients [11]; another study showed that high doses of vitamin D reduced inflammatory markers significantly in patients with COVID 19 without any side effects [12]. Based on the results of the study, sun exposure is not only a factor in the body's resistance during the pandemic, but also helps in its recovery.…”

Section: Effect Of Sun Exposure On Covid-19 and The Body's Resilience...mentioning

confidence: 81%

Daylight Strategies in Learning Space in Covid-19 Pandemic

Sahputra¹,

Meutia²,

Edytia³

et al. 2022

Advances in Social Science, Education and Humanities Research

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Adaptation of new habits or new normal has a major impact in various sectors, including education. The learning process in all educational institutions either formal or non-formal, begins with blended learning, a combination of online and offline learning methods. By implementing health protocols, some educational institutions such as Taman Pendidikan Al-Qur'an (TPA) are conducting face-to-face learning, for example, TPA As Sakinah in Kopelma Darussalam, Banda Aceh and Balee Aleh Ba in Kajhu, Aceh Besar. The purpose of this study is to examine the adequacy of natural lighting and airflow in both TPA learning spaces. This study aims to assess the feasibility of learning activities to adapt to the covid-19 pandemic that still happens today. The method used daylight application to simulate and measure the adequacy of incoming light intensity. Based on observation data in the field, a threedimensional modeling simulation will be conducted for design improvement as an intervention in the adaptation of space functions with activities based on covid-19 pandemic conditions.

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“…In our study, we analyzed the cycle threshold (Ct) which represents the number of replication cycles that are needed during real-time PCR to develop the target sample above a threshold level [27].The higher is the initial concentration of a target gene in a sample, the fewer is the number of required cycles to achieve threshold level, and the lower is the Ct value [28]. The present study found that Ct value trends were stable in placebo group and slightly increasing in intervention group.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation versus placebo on recovery delay among COVID-19 patients: A randomized-controlled clinical trial

Abroug

Maatouk

Bennasrallah

et al. 2022

Preprint

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Introduction : The present study aimed to determine the impact of vitamin D supplementation on recovery delay among COVID-19 patients. Methods : We performed a randomized controlled clinical trial in the national center for COVID-19 confinement, from May to August 2020. Simple randomization was done in a 1:1 allocation ratio. We included patients aged more than 18 years who had confirmed RT PCR and who remained positive on the 14 th day. The intervention group received vitamin D supplementation (200,000 IU / 1 ml of Cholecalciferol), the control group received a placebo treatment (physiological saline (1 ml)). We measured the recovery delay and the E gene SARS-CoV-2 RT-PCR Cycle threshold (Ct) values. The Log rank test and Hazard ratios (HR) were calculated. Results : A total of 117 participants were enrolled. The mean age was 42.7 years (SD 14). Males represented 55.6%.The median duration of viral RNA conversion was 37 days ( 95% CI: 29-45.50) in intervention group and 28 days ( 95% CI: 23-39) in the placebo group (p=0.010). HR was 1.58 ( 95% CI: 1.09-2.29, p=0.015). Ct values revealed a stable trends over time in both groups. Conclusion : Vitamin D supplementation was not associated with a shortened recovery delay when given to patients for whom the RT-PCR remained positive on the 14th day. Trial registration: This study was approved by the Human Subjects Protection Tunisia center (TN2020-NAT-INS-40) on May 05, 2020 and by clinical trial.gov with approval number Clinical Trials.gov ID: NCT04883203.

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Retraction Note: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease

Cited by 17 publications

References 0 publications

Outdoor daylight exposure and longer sleep promote wellbeing under COVID‐19 mandated restrictions

Outdoor daylight exposure and longer sleep promote wellbeing under COVID‐19 mandated restrictions

Daylight Strategies in Learning Space in Covid-19 Pandemic

Effect of vitamin D supplementation versus placebo on recovery delay among COVID-19 patients: A randomized-controlled clinical trial

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