Retraction：Polyphosphate-induced matrix metalloproteinase-3-mediated differentiation in rat dental pulp fibroblast-like cells

Hiyama, Taiki; Ozeki, Nobuaki; Hase, Naoko; Yamaguchi, Hideyuki; Kawai, Rie; Kondo, Ayami; Mogi, Makio; Nakata, Kohei

doi:10.5582/bst.2015.01134

Cited by 2 publications

(1 citation statement)

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“…Similarly, the team found that matrix metalloproteinase-3 (MMP-3) has almost the same effect on rat dental pulp fibroblast-like cells (dental pulp stem cells). MMP-3 siRNA effectively inhibits the expression of osteogenic biomarkers, and polyP-induced MMP-3 regulates the differentiation of osteoblasts and rat dental pulp stem cells [43]. Further studies revealed that exogenous Wnt5 increased MMP-3 activity and accelerated the proliferation rate of dental pulp stem cells, while the transfection of a Wnt5 α siRNA could inhibit polyP-induced MMP-3 expression and cell proliferation.…”

Section: Polyp and Mesenchymal Stem Cellsmentioning

confidence: 99%

Progress and Applications of Polyphosphate in Bone and Cartilage Regeneration

Wang

Li²,

Li³

et al. 2019

BioMed Research International

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Patients with bone and cartilage defects due to infection, tumors, and trauma are quite common. Repairing bone and cartilage defects is thus a major problem for clinicians. Autologous and artificial bone transplantations are associated with many challenges, such as limited materials and immune rejection. Bone and cartilage regeneration has become a popular research topic. Inorganic polyphosphate (polyP) is a widely occurring biopolymer with high-energy phosphoanhydride bonds that exists in organisms from bacteria to mammals. Much data indicate that polyP acts as a regulator of gene expression in bone and cartilage tissues and exerts morphogenetic effects on cells involved in bone and cartilage formation. Exposure of these cells to polyP leads to the increase of cytokines that promote the differentiation of mesenchymal stem cells into osteoblasts, accelerates the osteoblast mineralization process, and inhibits the differentiation of osteoclast precursors to functionally active osteoclasts. PolyP-based materials have been widely reported in in vivo and in vitro studies. This paper reviews the current cellular mechanisms and material applications of polyP in bone and cartilage regeneration.

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Section: Polyp and Mesenchymal Stem Cellsmentioning

confidence: 99%