Retrobulbar Short Posterior Ciliary Artery Hemodynamics in Patients with Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

Doğan, Neşe Çetin; Özdemir, Nusret; Aikimbaev, Kairgeldy; Çiloğlu, Emine

doi:10.4103/joco.joco_59_21

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…However, the existing literature remains controversial regarding CDI findings in eyes with PXG compared to those with POAG [60][61][62][63]. • ↑RI in OA, CRA -Dogan et al, 2021 [61] • ↓PSV, ↓EDV in TSPCAs No statistical differences Kocaturk et al, 2016 [58] • ↓PSV, ↓EDV, ↑RI in OA -Sekeroglu et al, 2011 [57] • ↓PSV, ↓EDV, ↑RI (all vessels) -Martinez et al, 2008 [55] • ↓EDV, ↑RI (all vessels) - • ↓PSV, ↓EDV, ↑RI (all vessels) -Yuksel et al, 2001 [60] • ↓PSV, ↓EDV, ↑RI (all vessels) No statistical differences POAG: Primary Open Angle Glaucoma, PXG: Pseudoexfoliation Glaucoma, CRA: Central Retinal Artery, TSPCAs: Temporal Short Posterior Ciliary Arteries, PSV: Peak Systolic Velocity, EDV: End Diastolic Velocity, RI: Resistive Index.…”

Section: Pseudoexfoliation Glaucoma (Pxg)mentioning

confidence: 99%

The Role of Color Doppler Imaging in the Diagnosis of Glaucoma: A Review of the Literature

et al. 2023

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Glaucoma is a progressive optic neuropathy and one of the leading causes of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the major risk factor for the onset and progression of glaucoma. In addition to elevated IOP, impaired intraocular blood flow is also considered to be involved in the pathogenesis of glaucoma. Various techniques have been used to assess ocular blood flow (OBF), including Color Doppler Imaging (CDI), a technique used in ophthalmology in recent decades. This article reviews the role of CDI in both the diagnosis and effective monitoring of glaucoma progression, presenting the protocol for imaging and its advantages, as well as the limitations of its use. Moreover, it analyzes the pathophysiology of glaucoma, focusing on vascular theory and its role in the onset and progression of the disease.

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Section: Pseudoexfoliation Glaucoma (Pxg)mentioning

confidence: 99%

The Role of Color Doppler Imaging in the Diagnosis of Glaucoma: A Review of the Literature

et al. 2023

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“…Impaired retrobulbar blood flow has also been observed in pseudoexfoliation glaucoma and angle-closure glaucoma [63]. Retrobulbar blood flow changes in SPCA were similar in POAG and pseudoexfoliation subtypes [64]. The effects of IOP-lowering drugs on retrobulbar hemodynamics have yielded contradictory results.…”

Section: Clinical and Scientific Relevance Of CDI For Ocular And Card...mentioning

confidence: 99%

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

Böhm,

Grauhan,

Pfeiffer

et al. 2023

Diagnostics

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Abnormal retrobulbar hemodynamics have been linked to the development of various ocular diseases, including glaucoma, age-related macular degeneration, and diabetic retinopathy. Additionally, altered retrobulbar blood flow has been observed in patients with severe cardiovascular diseases, including carotid artery occlusion, stroke, heart failure, and acute coronary syndrome. Due to the complex and intricate anatomy of retrobulbar blood vessels and their location behind the eyeball, measurement of retrobulbar blood flow and vascular reactivity, as well as the interpretation of the findings, are challenging. Various methods, such as color Doppler imaging, computed tomography angiography or magnetic resonance imaging, have been employed to assess retrobulbar blood flow velocities in vivo. Color Doppler imaging represents a fast and non-invasive method to measure retrobulbar blood flow velocities in vivo. While no information about vessel diameter can be gained performing this method, computed tomography angiography and magnetic resonance imaging provide information about vessel diameter and detailed information on the anatomical course. Additionally, ex vivo studies, such as myography, utilizing genetically modified animal models may provide high optical resolution for functional vascular investigations in these small vessels. To our best knowledge, this is the first review, presenting a detailed overview of methods aiming to evaluate retrobulbar blood flow and vascular reactivity in both humans and laboratory animals. Furthermore, we will summarize the disturbances observed in retrobulbar blood flow in retinal, optic nerve, and cardiovascular diseases.

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Analysis of the relationship between VEGF, NLRP3 inflammatory complex, EPO levels, and ocular hemodynamics in patients with primary open-angle glaucoma

Zhang,

Gu,

2024

BMC Ophthalmol

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Objective Our study aimed to investigate the relationship between vascular endothelial growth factor (VEGF), NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammatory complex, erythropoietin (EPO) levels, and ocular hemodynamics in patients diagnosed with primary open-angle glaucoma (POAG). Methods This is a prospective observational study. Patients diagnosed with POAG at The Sixth Hospital of Wuhan hospital between November 2022 and February 2023were enrolled.The patients were categorized into three groups based on the average visual field defect (mean deviation, MD) value: severe injury group (MD > 12 dB, 93 cases), moderate injury group (7 ≤ MD ≤ 12 dB, 89 cases), and mild injury group (MD < 7 dB, 85 cases). The levels of VEGF, NLRP3 inflammatory complex, EPO, and ocular hemodynamics were compared among the groups. Furthermore, the relationship between VEGF, NLRP3, EPO levels, and ocular hemodynamics in patients with POAG was analyzed using Pearson correlation analysis. After adjusting for confounding factors such as age and gender, multivariate Logistic regression analysis was performed with the ocular hemodynamics indexes being used as dependent variables, and VEGF, NLRP3, ASC, Caspase-1, and EPO being used as independent variables. Results A total of267 patients with POAG were enrolled. There were no significant differences in sex, age, body mass index, systolic blood pressure, diastolic blood pressure, smoking, alcohol consumption, and blood glucose between the two groups ( P > 0.05). The levels of NLRP3, ASC, Caspase-1, and EPO in the severe and moderate injury groups were higher than those in the mild injury group, whereas the VEGF levels were lower in the severe and moderate groups compared to the mild group, showing significant differences ( P < 0.05). The severe group exhibited higher levels of NLRP3, ASC, Caspase-1, and EPO than the moderate group, while the VEGF levels were lower in the severe group compared to the moderate group, showing significant differences ( P < 0.05). The peak systolic velocity(PSV) and resistance index (RI) were higher in the severe and moderate groups than in the mild group, whereas the EDV was significantly lower in the severe and moderate groups compared to the mild group ( P < 0.05). The severe group exhibited higher PSV and RI values compared to the moderate group, while the EDV was lower in the severe group compared to the moderate group, showing significant differences ( P < 0.05). Pearson correlation analysis was performed to examine the relationship between VEGF, NLRP3, EPO levels, and ocular hemodynamics in patients with POAG. VEGF, NLRP3, ASC, Caspase-1, and EPO showed positive correlations with PSV and RI, and negative correlations with EDV in patients with POAG. Regression analysis showed that VEGF, NLRP3, ASC, Caspase-1 and EPO ...

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Retrobulbar Short Posterior Ciliary Artery Hemodynamics in Patients with Pseudoexfoliation Glaucoma and Primary Open-Angle Glaucoma

Cited by 3 publications

References 20 publications

The Role of Color Doppler Imaging in the Diagnosis of Glaucoma: A Review of the Literature

The Role of Color Doppler Imaging in the Diagnosis of Glaucoma: A Review of the Literature

Measurement of Retrobulbar Blood Flow and Vascular Reactivity—Relevance for Ocular and Cardiovascular Diseases

Analysis of the relationship between VEGF, NLRP3 inflammatory complex, EPO levels, and ocular hemodynamics in patients with primary open-angle glaucoma

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