Retrograde Ejaculation and
Loss of Emission: Possibilities
of Conservative Treatment

Gilja, Ivan; Parazajder, Josip; Radej, M; Cvitković, Petar; Kovačić, Marijan

doi:10.1159/000475288

Cited by 48 publications

(16 citation statements)

References 6 publications

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“…Impairment of sexual behavior,5 semen quality,2 and ejaculation7 are the most common reproductive consequences in diabetic men. Disrupted spermatogenesis and oligozoospermic cases of diabetes have also been reported 8,9.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats

Abbasi

Tabatabaei

Mazaheri

et al. 2013

World J Mens Health

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PurposeThe purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats.Materials and MethodsThe adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days.ResultsSesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p>0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p<0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p<0.05). The sperm progressive motility and viability were lower in the diabetic rats (p<0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p<0.05).ConclusionsIn summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.

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Section: Introductionmentioning

confidence: 99%

Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats

Abbasi

Tabatabaei

Mazaheri

et al. 2013

World J Mens Health

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show abstract

“…The most common sympathomimetics are synephrine, pseudoephedrine hydrochloride, ephedrine, phenylpropanolamine and midrodrine. Unfortunately as time progresses their effect diminishes (11). Many of the studies published about the efficacy of sympathomimetics in the treatment of retrograde ejaculation suffer from small sample size with some represented by case reports.…”

Section: Retrograde Ejaculationmentioning

confidence: 99%

Retrograde ejaculation, painful ejaculation and hematospermia

Parnham

Şerefoğlu

2016

Transl. Androl. Urol.

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Although there has been an increased interest on premature ejaculation in the recent years, our understanding regarding the disorders of retrograde ejaculation, painful ejaculation and hematospermia remain limited. All three of these conditions require a keen clinical acumen and willingness to engage in thinking outside of the standard established treatment paradigm. The development of novel investigational techniques and treatments has led to progress in the management of these conditions symptoms; however, the literature almost uniformly is limited to small series and rare randomised trials. Further investigation and randomised controlled trials are needed for progress in these often challenging cases.

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“…midodrine (53% success rate), appear to be the second choice. Chlorpheniramine is a first-generation alkylamine H1-antihistaminic drug used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria, while phenylpropanolamine acts as a potent and selective releasing agent of norepinephrine and epinephrine and it is commonly used in cough and cold preparations [71][72][73].…”

Section: Treatment Of Rementioning

confidence: 99%

Neurogenic Ejaculatory Disorders: Focus on Current and Future Treatments

Calabrò

Polimeni²,

Casella

et al. 2011

RPCN

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Ejaculation is a complex and still poorly understood neurological mechanism, at both spinal and cerebral levels as it is closely associated with orgasm. Physiologically, ejaculation is defined as the expulsion of seminal fluid from the urethral meatus and consists of two phases, namely emission and expulsion. Ejaculation is mediated by a spinal control center, referred to as a spinal pattern generator that coordinates sympathetic, parasympathetic and motor (somatic) outflows, integrating the latter with the inputs from the supraspinal sites in brainstem, hypothalamus and preoptic area. Premature ejaculation (PE) is the most common sexual dysfunction among young men, and it has been considered mostly psychogenic in origin, although it can be associated to diverse urological and neurological diseases. On the contrary, retrograde ejaculation and anejaculation are predominantly related to organic causes, particularly to neurogenic ones. Since ejaculation is mostly a spinal reflex, it is comprehensible that ejaculatory disorders are more frequent in spinal cord injury than in other neurological disorders. Over the past decades, research has focused on PE, and evidence from clinical studies showed a beneficial effect of antidepressants for the treatment of men with PE. Other ejaculatory disorders, especially painful ejaculation, have been less investigated and the proper therapy is still controversial. Aim of this review is to provide a comprehensive description of both currently available treatments and most promising future therapies, including assigned patents, for the neurogenic ejaculatory disorders.

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Retrograde Ejaculation and Loss of Emission: Possibilities of Conservative Treatment

Cited by 48 publications

References 6 publications

Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats

Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats

Retrograde ejaculation, painful ejaculation and hematospermia

Neurogenic Ejaculatory Disorders: Focus on Current and Future Treatments

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