Retroperitoneal Leiomyosarcoma and Enlarged Epididymis Associated with a Positive Pregnancy Test

Mansi, Ishak A.; Ashley, Ida; Glezerov, Valery

doi:10.1097/00000441-200208000-00010

Cited by 14 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Case 3 was a 57-year-old man who was found to have a 30-cm retroperitoneal mass by computerized tomography. The patient presented with progressive abdominal pain and weight loss (10). A pregnancy test performed on a urine sample by mistake was positive.…”

Section: Discussionmentioning

confidence: 99%

A High-Grade Uterine Leiomyosarcoma With Human Chorionic Gonadotropin Production

Liang

Stone

Chalas

et al. 2006

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Ectopic human chorionic gonadotropin production has been described in a wide variety of non-germ cell tumors, particularly in epithelial tumors, but rarely in sarcomas. In this report, we describe the case of 49-year-old woman with a history of "uterine fibroids," who presented with vaginal bleeding and a positive urine pregnancy test. After pregnancy was ruled out by ultrasound, the patient underwent a laparotomy and hysterectomy for a presumptive diagnosis of "fibroids" and was found to have carcinomatosis at the time of the surgery. Therefore optimal debulking of tumors was performed. Two weeks later, the patient developed a small bowel obstruction, which apparently was due to rapid recurrence of tumors in the abdomen, and soon afterwards she died. Microscopically, the resected pelvic mass was composed of highly atypical and pleomorphic spindle cells admixed with many multinucleated giant cells. The tumor had a high mitotic rate along with areas of hemorrhage and necrosis. Immunohistochemically, the tumor cells were positive for vimentin, desmin, smooth muscle actin, and beta-human chorionic gonadotropin, and were negative for epithelial membrane antigen, keratin AE1/3, S-100, CD31, CD117, Ber-EP4, WT-1, estrogen and progesterone receptors. The majority of cells, including the multinucleated giant cells, were strongly immunoreactive for beta-human chorionic gonadotropin. Only three cases of leiomyosarcomas with beta/human chorionic gonadotropin production have been described in the literature, and all three cases had extrauterine origin. Our case, to the authors' best knowledge, is the first uterine leiomyosarcoma with prominent beta/human chorionic gonadotropin production.

show abstract

Section: Discussionmentioning

confidence: 99%

A High-Grade Uterine Leiomyosarcoma With Human Chorionic Gonadotropin Production

Liang

Stone

Chalas

et al. 2006

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

show abstract

“…Typically, retroperitoneal LMSs have vague presenting symptoms. Moreover, LMSs have rarely produced ectopic hormones, such as ␤ -HCG [6][7][8] , insulin-like growth factor 2 [9] , parathyroid hormone [10] , and renin [11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Aldosterone- and Norepinephrine-Secreting Retroperitoneal Leiomyosarcoma

Wei²,

Zeng³

et al. 2008

Eur Surg Res

View full text Add to dashboard Cite

A case of retroperitoneal leiomyosarcoma (LMS) in a 38-year-old woman who had a tumor in the retroperitoneum with severe hypertension and hypokalemia is presented. Further investigation revealed an elevated serum aldosterone and norepinephrine level. After tumorectomy, the levels of serum aldosterone and norepinephrine successfully normalized; hypertension and hypokalemia were also cured. The tumor was diagnosed as being a LMS by pathologic examination. We suggested that this was the first case of retroperitoneal LMS shown to be associated with increased levels of serum aldosterone and norepinephrine.

show abstract

“…In sarcomas, a paraneoplastic syndrome with beta-hCG is rare: Meredith et al (1986), Gohji et al (1993), Seidl et al (1998) and Mansi et al (2002) found high levels of beta-hCG in four leiomyosarcomas of the small bowel, paratesticular, the spermatic cord and retroperitoneal.…”

Section: Discussionmentioning

confidence: 99%

“…Production of beta-hCG by sarcomas is an uncommon phenomenon that has rarely been documented. We only found a few cases in the literature: one chondrosarcoma (Mack et al 1977), four leiomyosarcomas (Meredith et al 1986;Gohji et al 1993;Seidl et al 1998;Mansi et al 2002) and five osteosarcomas (Goldstein et al 1974;Gailani et al 1976;Kalra et al 1984;Ordonez et al 1989) with high levels of beta-hCG.…”

Section: Introductionmentioning

confidence: 89%

High level of beta-hCG simulating pregnancy in recurrent osteosarcoma: case report and review of literature

Leidinger

Bielack

Koehler³

et al. 2004

Journal of Cancer Research and Clinical Oncology

View full text Add to dashboard Cite

show abstract

Retroperitoneal Leiomyosarcoma and Enlarged Epididymis Associated with a Positive Pregnancy Test

Cited by 14 publications

References 8 publications

A High-Grade Uterine Leiomyosarcoma With Human Chorionic Gonadotropin Production

A High-Grade Uterine Leiomyosarcoma With Human Chorionic Gonadotropin Production

An Unusual Case of Aldosterone- and Norepinephrine-Secreting Retroperitoneal Leiomyosarcoma

High level of beta-hCG simulating pregnancy in recurrent osteosarcoma: case report and review of literature

Contact Info

Product

Resources

About