Retrospective analysis of 25 women with malignant cystosarcoma phyllodes—treatment results

Soumarová, Renata; Seneklová, Z; H, Horová; Vojkovská, Hana; Horová, Ivana; Budíková, Marie; Růžičková, Jana; Jezková, B

doi:10.1007/s00404-003-0593-7

Cited by 40 publications

(28 citation statements)

References 11 publications

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“…26–33 Several studies describe the successful use of adjuvant radiotherapy in small numbers of patients after margin-positive mastectomies. 11,34–36 …”

Section: Discussionmentioning

confidence: 99%

A Prospective, Multi-Institutional Study of Adjuvant Radiotherapy After Resection of Malignant Phyllodes Tumors

et al. 2009

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Background Malignant phyllodes tumors of the breast are unusual neoplasms, with an incidence of approximately 500 cases annually in the United States. Published local recurrence rates after margin-negative breast-conserving resections of borderline malignant and malignant phyllodes tumors are unacceptably high, at 24 and 20%, respectively. It is uncertain whether radiotherapy after resection of phyllodes tumors is beneficial. Methods We prospectively enrolled patients who were treated with a margin-negative breast-conserving resection of borderline malignant or malignant phyllodes tumors to adjuvant radiotherapy. The primary endpoint was local recurrence. Results Forty-six women were treated at 30 different institutions. The mean patient age was 49 years (range, 18–76 years). Thirty patients (65%) had malignant phyllodes tumors; the rest were borderline malignant. The mean tumor diameter was 3.7 cm (range, .8–11 cm). Eighteen patients had a negative margin on the first excision. The median size of the negative margin was .35 cm (range, <.1–2 cm). Twenty-eight patients underwent a re-excision because of positive margins in the initial resection. Two patients died of metastatic phyllodes tumor. During a median follow-up of 56 months (range, 12–129 months), none of the 46 patients developed a local recurrence (local recurrence rate, 0%; 95% confidence interval, 0–8). Conclusions Margin-negative resection combined with adjuvant radiotherapy is very effective therapy for local control of borderline and malignant phyllodes tumors. The local recurrence rate with adjuvant radiotherapy was significantly less than that observed in reported patients treated with margin-negative resection alone.

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“…26–33 Several studies describe the successful use of adjuvant radiotherapy in small numbers of patients after margin-positive mastectomies. 11,34–36 …”

Section: Discussionmentioning

confidence: 99%

A Prospective, Multi-Institutional Study of Adjuvant Radiotherapy After Resection of Malignant Phyllodes Tumors

et al. 2009

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“…[6] 821 Malignant and borderline histology EQUIVOCAL Saumarova'R et al [8] 25 Malignant histology YES Stranzl H et al [9] 06 Malignant histology YES Erhan Y et al [10] 21 high mitotic rate, p53 and Ki-67 fraction YES…”

Section: Resultsmentioning

confidence: 99%

Largest Phyllodes Tumor- Case Report and Brief Review Article

Kumar

Patel

Bhargavan

et al. 2011

Indian J Surg Oncol

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This is an article reporting the largest phyllodes tumor and the role of radiotherapy in patients of phyllodes tumor of breast, based on Medline search for articles in English language using keywords "role of radiotherapy in phyllodes tumor of breast". 32 years female presented with a lump in right breast since last 4 months. This was the second recurrence of similar lump in last 6 years. Biopsy from the lump proved to be cystosarcoma phyllodes. Radical Mastectomy with level I node sampling and reconstruction with Latissimus Dorsi Myocutaneous flap was done as a curative procedure. The tumor measured exactly to be 50×25.2×16.4 cm in size and 15 kg in weight. Proliferation markers like Ki-67 and p53 were in the range of 1-2% and 3-4% respectively. Histopathological diagnosis of the tumor was borderline phyllodes tumor. Patient had an uneventful postoperative course and is presently on three monthly follow up since 1 year.

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“…Thus, the investigators recommended adjuvant RT for all malignant PT irrespective of the type of surgery. [54] Similarly, the use of RT for tumors with high risk of local recurrence has been proposed by Bouhfa et al [55] In a retrospective analysis by Spitaleri et al, of nine patients who received adjuvant RT, none of them relapsed. [40] In two recent studies, adjuvant RT was associated with better local control.…”

Section: Efficacy Of Adjuvant Radiotherapymentioning

confidence: 96%

Phyllodes tumor of the breast: Wolf inside the sheep’s skin!

Wadasadawala¹,

Swain²,

Bajpai³

2016

Oncobiology and Targets

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Phyllodes tumor, previously known as cystosarcoma phyllodes, is a rare fibro-epithelial tumor of breast constituting <1% of all the breast tumors. It is classified into benign, borderline, and malignant subtypes depending upon the histological criteria defined by the World Health Organization and also has an independent prognostic significance. Accurate pretreatment histological diagnosis is important for the optimal management of phyllodes tumor so that low recurrence rates, improved survival, and optimal long-term cosmetic result can be achieved. Despite surgery being the standard of care, the best type of surgery for each histological type is yet to be defined. The higher rate of local recurrence after surgery alone in borderline and malignant phyllodes tumor raises the question regarding the need of adjuvant treatment, especially radiotherapy, which remains underutilized. The perspective of the current review is to provide the state-of-the-art management of phyllodes tumor of the breast and highlight the risk factors associated with recurrence.

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Retrospective analysis of 25 women with malignant cystosarcoma phyllodes—treatment results

Cited by 40 publications

References 11 publications

A Prospective, Multi-Institutional Study of Adjuvant Radiotherapy After Resection of Malignant Phyllodes Tumors

A Prospective, Multi-Institutional Study of Adjuvant Radiotherapy After Resection of Malignant Phyllodes Tumors

Largest Phyllodes Tumor- Case Report and Brief Review Article

Phyllodes tumor of the breast: Wolf inside the sheep’s skin!

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