Revelation of Mechanism of Action of Rhizophora Mucronata Poir. Bark Extract for Its Antidiabetic Activity by Gut Perfusion and Six Segment Method in Long Evans Rats

Haque, Mahamudul; Ahmed, Asma; Nasrin, Shamema; Rahman, Md. Mahbubur; Raisuzzaman, Shaikh

doi:10.7897/2230-8407.04522

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…Gaffar et al (2011) investigated the antidiabetic effect of R. mucronata, which is due to its capacity to inhibit carbohydrate digestion and absorption. Haque et al (2013) reported that the aqueous bark extracts of R. mucronata possess significant hypoglycaemic and antihyperglycaemic activities. The bark extracts of this plant showed dose-dependent antidiabetic effects, which significantly suppressed postprandial hyperglycaemia.…”

Section: Rhizophora Spmentioning

confidence: 99%

Antidiabetic potential of mangrove plants: a review

Das

Samantaray

Patra

et al. 2015

Frontiers in Life Science

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Diabetes mellitus is a heterogeneous group of metabolic disorders characterized by persistent hyperglycaemia and becoming a serious threat to mankind health in all parts of the world. Production of reactive oxygen species and disturbed capacity of antioxidant defence have been reported for enhanced production of free radicals in diabetic subjects. As oxidative stress is found to be a central event in the development of diabetic complications, hence antioxidants may play an important role in the improvement of diabetes and its associated complications. Currently there has been an increased interest globally to identify antioxidant compounds that are pharmacologically potent and have low or no side effects. Phytochemicals and metabolites from mangrove plants are reported to exhibit strong antioxidant properties in terms of both enzymatic and non-enzymatic activities. Recent researches have also revealed that a number of mangrove plants have shown antidiabetic activities attributed to their unique metabolites such as flavonoids, triterpenoids, limonoids and polysaccharides. Thus, mangrove plants can be of great use in tackling diabetic and its associated oxidative stress mediated complications. The present review highlights a relation between oxidative stress and diabetes and the role of mangrove plants in alleviating diabetes, in general, and oxidative stress mediated diabetic complications, in particular.

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Section: Rhizophora Spmentioning

confidence: 99%

Antidiabetic potential of mangrove plants: a review

Das

Samantaray

Patra

et al. 2015

Frontiers in Life Science

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“…Pandey., et al [65] have also reported about the hypoglycemic effects of leaves of R. mucronata in the management of diabetes. In a similar study Haque., et al [66] observed a considerable decrease of postprandial hyperglycemia following sugar intake by this plant's bark.…”

Section: Avicennia Marinamentioning

confidence: 92%

The Effectiveness of Selected Saudi Medicinal Plants in the Management of Diabetes Mellitus: A Review

Zeid¹

2019

Act Scie Pharma

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Diabetes mellitus (DM) is a chronic metabolic illness which is distinguished by a long-term hyperglycaemic condition [1,2]. According to contemporary and universally trajectory of DM disease and by the year 2040, there will be about 642 million diabetic subjects [3]. In so many communities it is devastatingly inflicts a major socio economic problem in humans, especially to the adversely attacked patients. As a metabolic disorder, DM is the underlying precipitant of many crucial debilitating diseases especially the nephropathy, peripheral polyneuropathy, retinopathy, atherosclerosis, peripheral arterial disorder, coronary artery disease, and cerebrovascular disorder [4][5][6][7][8][9]. The prevalence of end stage renal disease is higher amongst patients with DM [10].The financial burden related to diabetes resulted mainly from both the expenses of medical treatment as well as the expensive

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“…It was correlated to the presence of insulin-like protein in the extracts [28]. Antidiabetic activity of the aqueous bark extracts of R. mucronata was reported, and the proposed pathway was the glucose absorption inhibition [29].…”

Section: Antidiabetic Activity Using α-Amylase Inhibition Assaymentioning

confidence: 95%

Characterisation of nitrogen-containing organic compounds by UHPLC-Qtof-MS and anti-amylase activity from the chloroform extract of the bark of Rhizophora mucronata

et al. 2021

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Background Medicinal importance of mangrove plant Rhizophora mucronata, a red mangrove species found in the Asian countries, has long been recognised in traditional systems of medicine. The identification of its phytoconstituents can be a starting point for the drug development. The aim of the work was to extend the current knowledge of phytoconstituents from R. mucronata and to explore its pharmacological importance in the treatment of diabetes mellitus. In the present study, we analysed the chloroform extract from the bark of the mangrove plant R. mucronata for nitrogen-containing constituents using UHPLC QTOF MS profiling, and α-amylase inhibition assay was carried out. Results Four nitrogen-containing compounds were identified from the chloroform extract of the bark of R. mucronata using UHPLC QTOF MS profiling. The compounds identified were N,N′-dicyclohexyl urea, a cryptolepine derivative (C17H15N3O), an aliphatic cyclic compound with hydroxyl and amino groups (C22H43NO), and C16H19NO2 (m/z 258.1495). The anti-amylase activity, an in vitro antidiabetic bioassay, of chloroform extract showed an IC50 value of 220.09 μg/ml. Conclusions This is the first report on the identification of nitrogen-containing compounds from the chloroform extract of the bark of the R. Mucronata. One of the compounds identified was a novel cryptolepine derivative (C16H13N3O), and it falls under the rare category indoloquinoline alkaloid. The chloroform extract also showed significant activity towards α-amylase inhibition assay. Thus, the study has gone some way towards our understanding of the efficacy of bark of the R. mucronata for the treatment of diabetes mellitus and is open for further research.

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Revelation of Mechanism of Action of Rhizophora Mucronata Poir. Bark Extract for Its Antidiabetic Activity by Gut Perfusion and Six Segment Method in Long Evans Rats

Cited by 7 publications

References 7 publications

Antidiabetic potential of mangrove plants: a review

Antidiabetic potential of mangrove plants: a review

The Effectiveness of Selected Saudi Medicinal Plants in the Management of Diabetes Mellitus: A Review

Characterisation of nitrogen-containing organic compounds by UHPLC-Qtof-MS and anti-amylase activity from the chloroform extract of the bark of Rhizophora mucronata

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