Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis

Umemoto, Norio; Ishii, Hideki; Kamoi, Daisuke; Aoyama, Toru; Sugihara, Takashi; Tanaka, Akihito; Yasuda, Yoshinari; Suzuki, Susumu; Murohara, Toyoaki

doi:10.1016/j.atherosclerosis.2016.03.037

Cited by 20 publications

(11 citation statements)

References 25 publications

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“…Moreover, it has been reported that compared with healthy individuals, patients with CKD have reduced levels of plasma n-3 PUFA (Madsen et al, 2011 ). Furthermore, it was demonstrated in many studies that in hemodialysis patients, ω-3 PUFA is significantly decreased (Gharekhani et al, 2014 ; Hung et al, 2015 ; Umemoto et al, 2016 ). Highly prevalent systemic inflammation is related to a high mortality rate due to cardiovascular issues in CKD patients who are on dialysis.…”

Section: Discussionmentioning

confidence: 99%

An Integrated Lipidomics and Phenotype Study Reveals Protective Effect and Biochemical Mechanism of Traditionally Used Alisma orientale Juzepzuk in Chronic Kidney Disease

et al. 2018

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Alisma orientale Juzepzuk (AO) is widely used for various diuretic and nephropathic treatments in traditional Chinese medicines (TCM). In a clinical setting, AO is used as both a lipid-lowering and tubular interstitial fibrosis agent. However, the mechanisms of AO for the treatment of renal interstitial fibrosis and abnormal lipid metabolism are not well-understood. In this study, pharmacological and UPLC-HDMS-based lipidomic approaches were employed to investigate the lipid-lowering and tubular interstitial fibrosis effect of AO on rats with adenine-induced chronic kidney disease (CKD). Rats with CKD showed increased serum levels of creatinine and urea, tubular damage, and tubular interstitial fibrosis. Moreover, multiple lipid species were identified in CKD rats. Among these lipids, polyunsaturated fatty acid, eicosapentaenoic acid, 8,9-epoxyeicosatrienoic acid, and docosahexaenoic acid levels were significantly decreased in CKD rats compared to control rats. In CKD rats, up-regulation of the NF-κB pathway may impair polyunsaturated fatty acid metabolism, causing renal fibrosis. In addition, CKD rats showed significantly decreased diglyceride levels and increased triglyceride levels compared to the control group. Pathway over-representation analysis demonstrated that 30 metabolic pathways were associated with lipid species. AO treatment suppressed up-regulation of inflammation, and partly restored the deregulation of polyunsaturated fatty acids and glycerolipids metabolism. Our results indicated that AO treatment attenuated renal fibrosis by down-regulating inflammation, and mitigating lipid metabolism in CKD rats. In conclusion, this study has identified the therapeutic lipid-lowering and anti-fibrosis effects of AO on CKD.

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Section: Discussionmentioning

confidence: 99%

An Integrated Lipidomics and Phenotype Study Reveals Protective Effect and Biochemical Mechanism of Traditionally Used Alisma orientale Juzepzuk in Chronic Kidney Disease

et al. 2018

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“…Indeed, serum EPA to AA ratio (EPA/AA) has been found to be a good biomarker for CVD risk not only in the general population 50) but also in a post hoc analysis of the results of a clinical trial 51) . Intima-media thickness in carotid arteries, PWV, and cardio-ankle vascular index are surrogate markers for atherosclerotic diseases, and EPA/AA and DHA to AA ratio (DHA/AA) were found to be associated with these markers [52][53][54][55] . Albuminuria is also recognized as an independent risk factor for CVD morbidity and mortality in the general population 56,57) .…”

Section: Anti-inflammatory and Cardioprotective Effect Of Fish Oil: Amentioning

confidence: 99%

Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved

Watanabe

Tatsuno

2020

JAT

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The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Review PUFA, are considered essential fatty acids because they cannot be synthesized by humans. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are representatives of omega-3 PUFA, and they can be converted from ALA in vivo. EPA and DHA are attracting attention due to their anti-arteriosclerotic effect. This article overviews the knowledge on the prevention of cardiovascular (CV) events with omega-3 PUFA and the mechanisms involved, focusing on the history of research on the anti-arteriosclerotic effect of fish oil. History of Fish Oil and Lifestyle-Related Diseases Mortality rate from atherosclerotic cardiovascular diseases (CVD), particularly myocardial infarction Copyright©2019 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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“…However, there is a disproportionally high proportion of n-6 FAs and low proportion of n-3 FAs in our current dietary structure. This results in a high ratio of n-6/n-3, which is associated with cardiovascular disease, inflammation and cancer (1)(2)(3). The n-3 FAs are long-chain polyunsaturated FAs.…”

Section: Introductionmentioning

confidence: 99%

Apoptosis is induced by docosahexaenoic acid in breast cancer cells via death receptor and mitochondria-mediated pathways

Xue

et al. 2017

Molecular Medicine Reports

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In the present study, the antitumor effect of n‑3 fatty acid was evaluated, and the effect of docosahexaenoic acid (DHA) on the induction of apoptosis and its underlying mechanism were examined. Flow cytometry and western blot analysis were performed to analyze apoptosis and the expression of protein factors in human breast cancer cells. The data revealed that DHA inhibited the viability of MCF‑7 breast cancer cells in vitro, and promoted cell death by the induction of apoptosis. DHA decreased the expression of B‑cell lymphoma 2 (Bcl‑2), whereas the expression of Bcl‑2‑associated X protein was increased. DHA was also shown to promote the release of Smac/Diablo and cytochrome c from the mitochondria. DHA increased the levels of cleaved caspase‑8, ‑9 and ‑3. Additionally, the protein expression of tumor necrosis factor‑related apoptosis‑inducing ligand, death receptor 4 and Fas were increased following DHA treatment. In conclusion, DHA caused apoptosis of the human breast cancer cells in vitro through the death receptor and mitochondria‑mediated pathways. The results of this study encourage further investigation of the effect of fish oil on the prevention and treatment of human breast cancer.

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Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis

Cited by 20 publications

References 25 publications

An Integrated Lipidomics and Phenotype Study Reveals Protective Effect and Biochemical Mechanism of Traditionally Used Alisma orientale Juzepzuk in Chronic Kidney Disease

An Integrated Lipidomics and Phenotype Study Reveals Protective Effect and Biochemical Mechanism of Traditionally Used Alisma orientale Juzepzuk in Chronic Kidney Disease

Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved

Apoptosis is induced by docosahexaenoic acid in breast cancer cells via death receptor and mitochondria-mediated pathways

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