Reversible organogels triggered by dynamic K+ binding and release

Wang, Xiaoguang; Zhou, Lipeng; Wang, Haoyu; Luo, Quan; Xu, Jing

doi:10.1016/j.jcis.2010.09.089

Cited by 37 publications

(19 citation statements)

References 62 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Analytical techniques like FT-IR, NMR Spectroscopy, X-Ray diffraction [29] analysis have been employed for the characterization of organogels. These methods provide valuable information regarding molecular interaction during aggregation of organogelator molecules.…”

Section: Methodsmentioning

confidence: 99%

“…Primary structure (A° to nm scale) is composed of unidirectional aggregation of gelator molecules. The secondary structure (nm to μm scale) is nothing but the morphology of the aggregates like micelles, vesicles, fibers, ribbons [29,30] or sheets. Whereas tertiary structure of a gel (μm to mm scale) involves the interaction of individual aggregates to form gel network.…”

Section: Mechanism Of Gel Formationmentioning

confidence: 99%

See 1 more Smart Citation

Oleogel: A promising base for transdermal formulations

Balasubramanian¹,

Damodar²,

Sughir³

2012

Asian J Pharm

View full text Add to dashboard Cite

S ince last two decades the work on oleogels is being exploited in pharmaceutical, cosmetics, and nutraceutical industries for their desired rheological, physical, and chemical stabilities in semisolid formulations. Recently, we had developed a stable and efficacious oleogel containing diclofenac diethylamine for topical application. The present review article deals with the literature of oleogels including its application in various fields from last few decades till date. The literature reveals that the oleogels have simplicity in manufacturing, high physical, chemical, and mechanical stability and better invivo efficacy, which make them appropriate to employ as bases for topical formulations.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Mechanism Of Gel Formationmentioning

confidence: 99%

Oleogel: A promising base for transdermal formulations

Balasubramanian¹,

Damodar²,

Sughir³

2012

Asian J Pharm

View full text Add to dashboard Cite

show abstract

“…During the past two decades, more and more attention has been paid to the synthesis of supramolecular organogels due to their special properties and potential applications in fields such as drug delivery [1,2], inorganic nanomaterials [3,4], biofilm simulation [5,6], liquid crystallines [7,8], photochemistry [9,10], and electrochemistry [11,12]. It is well known that organogelators, possessing functional groups like hydroxyl, amide, linear alkyl chains, aromatic group, are able to self-assemble into aggregates with diverse morphologies such as fibers, sheets, ribbons through non-covalent interaction including hydrogen bonding, van der Waals force, p-p stacking, coordination interaction, and charge transfer [13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Two-component supramolecular organogels formed by maleic N-monoalkylamides and aliphatic amines

Luo

Zhixing

Xiao

et al. 2011

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

“…SO also showed a similar spectra as that of sample A and AD except the absence of the broad peak in the range of 3700 cm −1 –3100 cm −1 . This suggested the presence of stretched hydrogen bonded OH groups in the samples A and AD indicating the presence of intermolecular hydrogen bonds, which play an important role in formation of solid fiber organogels 55. Peaks observed for sample AD were more intense than that of sample A which might be attributed to the presence of SA within its structure.…”

Section: Resultsmentioning

confidence: 91%

Span‐60‐based organogels as probable matrices for transdermal/topical delivery systems

Behera

Patil

Sagiri

et al. 2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

The current study describes the preparation and characterization of thermoreversible span-60 and sunflower oil (SO)-based organogels as a matrix for drug delivery. Effect of gelator concentration on the properties of the organogels was studied by physical property evaluation, stability, light microscopy, FTIR spectroscopy, XRD, thermal analysis, pH, and hemocompatibility studies. The drug release kinetics and antimicrobial efficacy of the salicylic acid loaded organogels were studied. The rate of gelation of the gels was found to be quicker in organogels with higher gelator proportions. The gels were inherently stable when stored below 25 C. The micrographs indicated the presence of needle-shaped crystals which formed aggregates resulting in the formation of three-dimensional networked structures. FTIR indicated intermolecular hydrogen bonding amongst SO and span-60 molecules responsible for the gelation. There was an increase in the crystallinity and the melting point of the organogels as the proportion of the organogelator was increased. The pH of the organogels indicated nonirritant nature of the gels, which were also found to be hemocompatible. The release of SA from organogels followed Higuchian kinetics and showed prolonged antimicrobial activity. The preliminary results indicated that the organogels may be tried as a matrix for controlled drug delivery.

show abstract

Reversible organogels triggered by dynamic K+ binding and release

Cited by 37 publications

References 62 publications

Oleogel: A promising base for transdermal formulations

Oleogel: A promising base for transdermal formulations

Two-component supramolecular organogels formed by maleic N-monoalkylamides and aliphatic amines

Span‐60‐based organogels as probable matrices for transdermal/topical delivery systems

Contact Info

Product

Resources

About