Review and Analysis of CMOS Current Readout Circuits for Biosensing Applications

Awan, Muhammad Asfandyar; Wang, Bo; Quadir, Nasir Abdul; Bermak, Amine

doi:10.1109/iscas51556.2021.9401662

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…However, different from the conventional designs, our system is limited by the bandwidth requirements, i.e., 20 kHz, therefore, R diff will be chosen such that it can fulfill the bandwidth requirement. The equivalent input-referred current noise density of this converter is [30…”

Section: Circuit Design Consideration 1) Input Current Buffermentioning

confidence: 99%

A Laser Doppler Blood Flow Measurement System With a 151.4 dBΩ Gain and 0.05% Nonlinearity for PAD Patients

2022

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Section: Circuit Design Consideration 1) Input Current Buffermentioning

confidence: 99%

A Laser Doppler Blood Flow Measurement System With a 151.4 dBΩ Gain and 0.05% Nonlinearity for PAD Patients

2022

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“…When the single-stranded DNA (ssDNA) enters the nanopore, the flow of ions is blocked by the deoxynucleotide, causing a current drop. Therefore, genetic information on DNA can be read in real time by detecting the ion current or the equivalent conductance of the nanopore in the process [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A potentiostat readout array for nanopore-based DNA sequencing

Wang,

Jin,

Tang

et al. 2024

IEICE Electron. Express

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Nanopore-based DNA sequencing technology features the advantages of label-free, low-cost, and rapid detection. However, the existing nanopore sequencing readout cell or array for the lower area and power consumption become prohibitive. This brief presents a low noise potentiostat readout array. Based on the five-transistor OPA, the half-shared amplifier reduces the area and power consumption of the cell by about 50%, and shows a good suppression effect on mid-to-high frequency noise in the output channel. As a result, high-throughput is achieved with low noise. The performance of the proposed array channel has been evaluated in 180-nm CMOS process, the inputreferred current transient noise was 2.28 pARMS, the power consumption was 2.2 µW and the unit area was 10×12 µm 2 .

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“…In the combination of bioengineering and integrated circuit technology, the development of accurate current sensing integrated circuits (ICs) is a hot research topic in recent years, especially in the field of biosensing systems, such as ion current detection technology and nanotechnology as shown in Figure 1 (Awan, Wang, Quadir, & Bermak, 2021). This trend of interdisciplinary penetration makes the real-time, sensitive, and robust biosensor system based on CMOS technology more popular (Xu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

A review and analysis of current-mode biosensing front-end ICs for nanopore-based DNA sequencing

et al. 2022

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Bio-sensors connect the biological world with electronic devices, widely used in biomedical applications. The combination of microelectronic and medical technologies makes biomedical diagnosis more rapid, accurate, and efficient. In this article, the current-mode biosensing front-end integrated circuits (ICs) for nanopore-based DNA sequencing are reviewed and analyzed, aiming to present their operation theories, advantages, limitations, and performances including gain, bandwidth, noise, and power consumption. Because biological information and external interference are contained in extremely weak sensing current, usually at the pA or nA level, it is challenging to accurately detect and restore the desired signals. Based on the requirements of DNA sequencing, this paper shows three circuit topologies of biosensing front-end, namely, discrete-time, continuous-time, and current-to-frequency conversion types. This paper also makes an introduction to the current-mode sensor array for DNA sequencing. To better review and evaluate the research of the state-of-the-art, the most relevant published works are summarized and compared. The review and analysis would help the researchers be familiar with the requirements, constraints, and methods for current-mode biosensing front-end IC designs for nanopore-based DNA sequencing.

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Review and Analysis of CMOS Current Readout Circuits for Biosensing Applications

Cited by 8 publications

References 22 publications

A Laser Doppler Blood Flow Measurement System With a 151.4 dBΩ Gain and 0.05% Nonlinearity for PAD Patients

A Laser Doppler Blood Flow Measurement System With a 151.4 dBΩ Gain and 0.05% Nonlinearity for PAD Patients

A potentiostat readout array for nanopore-based DNA sequencing

A review and analysis of current-mode biosensing front-end ICs for nanopore-based DNA sequencing

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