Review—Electrochemical Detection of Uric Acid, Dopamine and Ascorbic Acid

Tukimin, Nurulkhalilah; Abdullah, Jaafar; Sulaiman, Yusran

doi:10.1149/2.0201807jes

Cited by 83 publications

(57 citation statements)

References 113 publications

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“…The high affinity of aptamer-dopamine binding (KD ≈ 5 nM) was found by the analysis of the binding kinetics. The occurrence of aptamer-dopamine binding was directly confirmed with spectroscopic ellipsometry measurements.Chemosensors 2020, 8, 28 2 of 11 done on the electrochemical detection of dopamine and other neurotransmitters [2,3]. Dopamine can be very easily detected in an aqueous solution by electrochemical methods such as cyclic voltammetry since dopamine undergoes electrochemical oxidation.…”

mentioning

confidence: 99%

“…However, a major issue is the selectivity since complex matrices such as blood contain a range of other oxidizable compounds such as urate or ascorbate which would also generate signals, leading to inaccurate readings. Selectivity towards dopamine is therefore required.A wide range of electrode materials have been proposed to increase the selectivity of dopamine detection [2,3]. A few recent examples include the use of materials such as Nafion combined with graphite [4] or multi-walled carbon nanotubes [5] to improve the selectivity towards dopamine.…”

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confidence: 99%

“…Composites of graphene oxide with Bi 2 S 3 nanorods were used for the electrochemical determination of dopamine [13], and arrays of cylindrical gold nanoelectrodes could be used for both the detection of dopamine and for the immobilization and growth of human neural cells [14]. Many other systems based on organic and inorganic materials have been reported for the sensing of dopamine [2,3].Synthetic bio-receptors such as aptamers appeared to be highly attractive for selective detection of dopamine [15][16][17]. Aptamers are artificial, relatively short single strand DNA or RNA oligomers having a particular sequence of nucleotides designed to accommodate a target molecule, e.g., dopamine.…”

mentioning

confidence: 99%

“…Chemosensors 2020, 8, 28 2 of 11 done on the electrochemical detection of dopamine and other neurotransmitters [2,3]. Dopamine can be very easily detected in an aqueous solution by electrochemical methods such as cyclic voltammetry since dopamine undergoes electrochemical oxidation.…”

mentioning

confidence: 99%

“…A wide range of electrode materials have been proposed to increase the selectivity of dopamine detection [2,3]. A few recent examples include the use of materials such as Nafion combined with graphite [4] or multi-walled carbon nanotubes [5] to improve the selectivity towards dopamine.…”

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Electrochemical Aptasensor for Detection of Dopamine

et al. 2020

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This work presents a proof of concept of a novel, simple, and sensitive method of detection of dopamine, a neurotransmitter within the human brain. We propose a simple electrochemical method for the detection of dopamine using a dopamine-specific aptamer labeled with an electrochemically active ferrocene tag. Aptamers immobilized on the surface of gold screen-printed gold electrodes via thiol groups can change their secondary structure by wrapping around the target molecule. As a result, the ferrocene labels move closer to the electrode surface and subsequently increase the electron transfer. The cyclic voltammograms and impedance spectra recorded on electrodes in buffer solutions containing different concentration of dopamine showed, respectively, the increase in both the anodic and cathodic currents and decrease in the double layer resistance upon increasing the concentration of dopamine from 0.1 to 10 nM L −1 . The high affinity of aptamer-dopamine binding (KD ≈ 5 nM) was found by the analysis of the binding kinetics. The occurrence of aptamer-dopamine binding was directly confirmed with spectroscopic ellipsometry measurements.Chemosensors 2020, 8, 28 2 of 11 done on the electrochemical detection of dopamine and other neurotransmitters [2,3]. Dopamine can be very easily detected in an aqueous solution by electrochemical methods such as cyclic voltammetry since dopamine undergoes electrochemical oxidation. However, a major issue is the selectivity since complex matrices such as blood contain a range of other oxidizable compounds such as urate or ascorbate which would also generate signals, leading to inaccurate readings. Selectivity towards dopamine is therefore required.A wide range of electrode materials have been proposed to increase the selectivity of dopamine detection [2,3]. A few recent examples include the use of materials such as Nafion combined with graphite [4] or multi-walled carbon nanotubes [5] to improve the selectivity towards dopamine. Other researchers have utilized graphene-modified screen-printed electrodes [6] or graphene aerogels [7] as substrates for the selective determination of dopamine. Composites of carbon nanotubes and graphene oxide could be used to determine dopamine, nitrate, ascorbate, and urate [8]. Metal nanoparticles have also been utilized, for example palladium nanoparticles combined with graphene [9], which were used as a base of electrochemical determination of dopamine whereas a gold nanoparticle/DNA/polymer composite could be used for the simultaneous determination of dopamine, uric acid, guanine, and adenine [10]. Composites of gold nanoparticles with conducting polymers have also been used for the selective determination of dopamine [11]. Boron-doped carbon nanotubes could be used to determine levels of dopamine and ephedrine in the presence of urate [12]. Composites of graphene oxide with Bi 2 S 3 nanorods were used for the electrochemical determination of dopamine [13], and arrays of cylindrical gold nanoelectrodes could be used for both the detection of dopamine an...

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confidence: 99%

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confidence: 99%

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Electrochemical Aptasensor for Detection of Dopamine

et al. 2020

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Wet‐Adhesive On‐Skin Sensors Based on Metal–Organic Frameworks for Wireless Monitoring of Metabolites in Sweat

Yang

Wang

et al. 2022

Advanced Materials

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Metal–organic frameworks (MOFs) with well‐defined porous structures and tailored functionalities have been widely used in chemical sensing. However, the integration of MOFs with flexible electronic devices for wearable sensing is challenging because of their low electrical conductivity and fragile mechanical properties. Herein, a wearable sweat sensor for metabolite detection is presented by integrating an electrically conductive Ni‐MOF with a flexible nanocellulose substrate. The MOF‐based layered film sensor with inherent conductivity, highly porous structure, and active catalytic properties enables the selective and accurate detection of vitamin C and uric acid. More importantly, the lightweight sensor can conformably self‐adhere to sweaty skin and exhibits high water‐vapor permeability. Furthermore, a wireless epidermal nutrition tracking system for the in situ monitoring of the dynamics of sweat vitamin C is demonstrated, the results of which are comparable to those tested by high‐performance liquid chromatography. This study opens a new avenue for integrating MOFs as the active layer in wearable electronic devices and holds promise for the future development of high‐performance electronics with enhanced sensing, energy production, and catalytic capabilities through the implementation of multifunctional MOFs.

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Wearable Sensors Based on Atomically Thin P‐Type Semiconductors

Jiang

Zhang

2023

Adv Materials Technologies

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Abstract2D materials have exceptional physical and chemical characteristics, which makes them attractive for wearable technology. These characteristics include high carrier mobility, outstanding mechanical performance, abundant chemistry, and excellent electrostatic tunability. However, due to the high electron doping effect of interfacial charge impurities and intrinsic defects, most reported 2D materials are n‐type. Complementary electronic devices and high‐performance wearable sensors necessitate the development of p‐type 2D semiconductors, which have superior electrocatalytic performance in oxidative processes compared to their n‐type counterparts. This review paper thoroughly accounts for recent advancements in 2D p‐type semiconductor‐based wearable sensors, covering basic understandings, synthesis and fabrication, functional devices, and sensor performance insights. Finally, challenges and future opportunities for 2D p‐type semiconductor‐based wearable sensors are discussed.

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Review—Electrochemical Detection of Uric Acid, Dopamine and Ascorbic Acid

Cited by 83 publications

References 113 publications

Electrochemical Aptasensor for Detection of Dopamine

Electrochemical Aptasensor for Detection of Dopamine

Wet‐Adhesive On‐Skin Sensors Based on Metal–Organic Frameworks for Wireless Monitoring of Metabolites in Sweat

Wearable Sensors Based on Atomically Thin P‐Type Semiconductors

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